CAS: 115540-28-8; Silane, [[(1β,3β,5E,7E,22E)-9,10-Secoergosta-5,7,10(19),22-Tetraene-1,3-Diyl]Bis(Oxy)]Bis[(1,1-Dimethylethyl)Dimethyl-

英文名称Silane, [[(1β,3β,5E,7E,22E)-9,10-Secoergosta-5,7,10(19),22-Tetraene-1,3-Diyl]Bis(Oxy)]Bis[(1,1-Dimethylethyl)Dimethyl-
中文名称硅烷,[(1β,3β,5E,7E,22E)-9,10-开环-5,7,10(19),22-四烯-1,3-二基]双(氧基)]双[(1,1-二甲基乙基)二甲基-
IUPAC名称(((1R,3R,E)-5-(2-((1R,3aS,7aR,E)-1-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diyl)bis(oxy))bis(tert-butyldimethylsilane)
其它别名((1R,3R,E)-5-((E)-2-((1R,3As,7Ar)-1-((2R,5R,E)-5,6-Dimethylhept-3-En-2-yl)-7A-Methyldihydro-1H-Inden-4(2H,5H,6H,7H,7Ah)-Ylidene)Ethylidene)-4-Methylenecyclohexane-1,3-Diyl)Bis(Oxy)Bis(Tert-Butyldimethylsilane); (((1R,3R,E)-5 - ((E)-2 - ((1R,3As,7Ar)-1 - ((2R,5R; (1S,3R)-Bis(Tert-Butyldimethylsilyloxy)-9,10-Seco-Ergosta-5(E),7(E),10(19),22(E)-Tetraene; ((1R,3R,E)-5-((E)-2-((1R,3As,7Ar)-1-((2R,5R,E)-5,6-Dimethylhept-3-En-2-yl)-7A-Methyldihydro-1H-Inden-4(2H,5H,6H,7H,7Ah)-Ylidene)Ethylidene)-4-Methylenecyclohexane-1,3-Diy...; 1(S),3(R)-Bis(Tert-Butyldimethylsiloxy)-9,10-Secoergosta-5(E),7(E),10(19),22(E)-Tetraene; Silane, [[(1β,3β,5E,7E,22E)-9,10-Secoergosta-5,7,10(19),22-Tetraene-1,3-Diyl]Bis(Oxy)]Bis[(1,1-Dimethylethyl)Dimethyl- (9Ci); Doxercalciferol Impurity 15; Calcipotriol Impurity 17
CAS编号115540-28-8
MFCD编号:MFCD22124637
分子式:C40H72O2Si2分子量:641.19
产品CID: 193118
产品分类有机原料→分子砌块→脂肪环类化合物→环己烷类化合物

相似结构搜索
InChIKey: UHCDRCBBCZLXBO-VIQBILSGSA-N
InChI=1S/C40H72O2Si2/c1-28(2)29(3)19-20-30(4)35-23-24-36-32(18-17-25-40(35,36)12)21-22-33-26-34(41-43(13,14)38(6,7)8)27-37(31(33)5)42-44(15,16)39(9,10)11/h19-22,28-30,34-
计算化学: 氢键受体数2.0氢键供体数*可旋转键数9.0

相似化合物

111594-58-2 127516-23-8 111594-58-2

MSDS等安全信息

上下游产品

Calciferol 6-benzo[c]thiophen-5-ol(S)-3-[(1R,3aS,7aR)-7a-Methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-°Ctahydro-inden-(4E)-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2λ6-benzo[c]thiophen-5-ol tert-butyldimethylsilyl chloride -9,10-secoergosta-5,7(E),10(19),22(E)-tetraeneSO2-adduct of 3(S)-(tert-butyldimethylsilyl)oxy-9,10-secoergosta-5,7(E),10(19),22(E)-tetraene (S)-5-[2-[(1R,3aS,7aR)-7a-Methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-°Ctahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-4-pentyl-cyclohex-3-enol tert-Butyl-dimethyl-{(S)-5-[2-[(1R,3aS,7aR)-7a-methyl-1-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-°Ctahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-4-pentyl-cyclohex-3-enyloxy}-silane 2 adducts of 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-9,10-secoergosta-5(E),7(E),10(19),22(E)-tetraene(6S)- and (6R)-SO2 adducts of 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-9,10-secoergosta-5(E),7(E),10(19),22(E)-tetraene 2 adduct of 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-20(S)-formyl-9,10-secopregna-5,7(E),10(19)-triene(6R)-SO2 adduct of 1(S),3(R)-bis(tert-butyldimethylsilyloxy)-20(S)-formyl-9,10-secopregna-5,7(E),10(19)-triene

合成工艺路线路线简述

合成目标产物 ((1R,3R,E)-5-((E)-2-((1R,3As,7Ar)-1-((2R,5R,E)-5,6-Dimethylhept-3-En-2-yl)-7A-Methyldihydro-1H-Inden-4(2H,5H,6H,7H,7Ah)-Ylidene)Ethylidene)-4-Methylenecyclohexane-1,3-Diyl)Bis(Oxy)Bis(Tert-Butyldimethylsilane) 主要起始原料 Tert-Butyldimethylsilyl Chloride
(文献来源)合成步骤主要原料 Tert-Butyldimethylsilyl Chloride

📜(3S,6R)-(Tert-Butyldimethylsilyloxy)-9,10-Seco-Ergosta-5,7(E),10(19),22(E)-Tetraene So2 Adduct置于咪唑,Selenium(Iv) Oxide,碳酸氢钠,N-甲基吗啉氧化物体系中,用甲醇,乙醇,二氯甲烷,N,N-二甲基甲酰胺用作溶剂,化学反应 3.83H,反应生成[[(1A,3B,5E,7E,22E)-9,10-开环麦角甾-5,7,10(19),22-四烯-1,3-基]双(氧)]双[(1,1-二甲基乙基)二甲基硅烷]
参考文献:具有生物活性的维生素d代谢物类似物mc 903的合成
标题:具有生物活性的维生素d代谢物类似物mc 903的合成
摘要:Mc 903(4)是一种由维生素d 2分12步合成的1,24-二羟基维生素d类似物,在侧链中含有一个双键和一个环丙烷环.
Doi:10.1016/s0040-4020(01)86903-9

海关参考信息

2901210000-乙烯
2901220000-丙烯
2901241000-1,3-丁二烯
2905122000-异丙醇
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主要参考文献

参考标题:Synthesis Of 24(28)-Methylene-1α-Hydroxyvitamin D3, A Novel Vitamin D3 Analogue
作者:Wei Guo,Zhijie Fang,Hongliang Li,Yanan Liu |发布日期:2014.4
摘要:24(28)-Methylene-1α-Hydroxyvitamin D3 Was Synthesised In 13 Steps From Vitamin D2. The Key Step Of The Synthesis Involved The Wittig-Horner Olefination Of A Nor-Vitamin D2 Aldehyde With Diethylphosphono-3-Methyl-2-Butanone. The Resulting Enone Was Followed By Reduced Methylenation, Photoisomerisation And Deprotection Then Gave The Target Compound.