CAS: 112704-79-7; 4-Bromo-2-Fluorobenzoic Acid

相似化合物

105942-08-3 57848-46-1 179232-29-2

上下游产品

CAS号51436-99-8 4-溴-2-氟甲苯 | CAS号124-38-9 二氧化碳 | CAS号1435-52-5 1,4-二溴-2-氟苯 | CAS号57848-46-1 4-溴-2-氟苯甲醛 | CAS号872545-52-3 (2-bromo-6-fluo... | CAS号1073-06-9 间溴氟苯 | CAS号915087-33-1 恩杂鲁胺 | CAS号259750-61-3 1-(4-溴-2-氟苯基)丙-1-酮 | CAS号869569-77-7 2-溴-1-(4-溴-2-氟苯基)乙酮 | CAS号749927-69-3 N-甲基-4-溴-2-氟-苯甲酰胺 | CAS号749927-80-8 4-溴-2-氟-N,N-二甲基苯甲酰胺 | CAS号72135-36-5 2-甲氧基-4-溴苯甲酸 | CAS号7746-27-2 6-溴-3-甲基吲唑 | CAS号625446-22-2 4-溴-2-氟苯乙酮 | CAS号1332524-01-2 N-[3-氟-4-[(甲基氨基... | CAS号1289942-66-0 N-(3-氟-4-((甲基氨基...

4'-溴-2'-氟苯乙酮置于copper(II) Nitrate Trihydrate,氧气体系中,用 乙腈 用作溶剂,180.0 °C,2.5 Mpa 条件下,反应 1.5H,以79%的收率获得4-溴-2-氟苯甲酸
参考文献:取代苯甲酸类有机物的连续化合成方法
标题:取代苯甲酸类有机物的连续化合成方法
摘要:本发明提供了一种取代苯甲酸类有机物的连续化合成方法.该连续化合成方法包括:在催化剂和有机溶剂的存在下,将式(ⅰ)所示的有机物与氧气连续地输入连续化反应装置进行连续氧化反应,得到取代苯甲酸类有机物,并连续排出,取代苯甲酸类有机物具有式(ⅱ)所示结构.氧气为绿色试剂,且廉价易得,反应结束后不会产生大量的三废,体系易处理.使用连续化反应操作能够降低高浓度氧在批次反应中使溶剂闪蒸爆炸的风险.在同等氧化条件中,采用连续化制备工艺能够减少了氧气的逃逸,使氧气利用率大大增加,也简化了操作,提高了反应的安全性和取代苯甲酸类有机物的收率.

专利信息

专利号:WO-2020248278-A1
优先权日:2019-06-14
标题:Method for continuous synthesis of substituted benzoic-acid organic substance
发明人：HONG HAO; ZHANG ENXUAN; LU JIANGPING; LIU ZHIQING; LI CHAO; TANG YANG
权利人:JINLIN ASYMCHEM LABORATORIES CO LTD
摘要:The present invention provides a method for the continuous synthesis of a substituted benzoic-acid organic substance. The continuous synthesis method comprises: in the presence of catalyst and organic solvent, the organic matter represented by formula (I) and oxygen are continuously inputted to a continuous reaction apparatus for continuous oxidation reaction to obtain a substituted benzoic-acid organic substance, which is discharged continuously, the substituted benzoic-acid organic substance having the structure represented by formula (II). Oxygen is a green reagent and is inexpensive and readily available; a large amount of wastewater, waste gas, and solid waste is not generated after the reaction, and the system is easy to handle. The use of a continuous reaction operation can reduce the risk of flash distillation and explosion of solvent due to a high concentration of oxygen in a batch reaction. Under the same oxidation conditions, the continuous preparation process can reduce the escape of oxygen, greatly increasing the oxygen utilization rate and also simplifying the operation, improving the safety of the reaction and the yield of the substituted benzoic-acid organic substance.

专利号:US-9174943-B2
优先权日:2010-02-24
标 题 :Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds
发明人：JAIN RAJENDRA PARASMAL; ANGELAUD REMY; THOMPSON ANDREW; LAMBERSON CAROL; GREENFIELD SCOTT
权利人:JAIN RAJENDRA PARASMAL; ANGELAUD REMY; THOMPSON ANDREW; LAMBERSON CAROL; GREENFIELD SCOTT; MEDIVATION PROSTATE THERAPEUTICS INC
摘要:Processes are provided for the synthesis of diarylthiohydantoin and diarylhydantoin compounds. Medicinal products containing the same find particular use in treating prostate cancer, including castration-resistant prostate cancer and/or hormone-sensitive prostate cancer.

专利号:US-2017190670-A1
优先权日:2014-07-11
标题:Improved process for the preparation of enzalutamide
发明人：HIRPARA SANJAY; SHRAWAT VIMAL KUMAR; POTHURAJU RAJU; TRIPATHI CHANDRESH KUMAR; AKSHAYKANT CHATURVEDI
权利人:SHILPA MEDICARE LTD
摘要:The present application relates to an improved process for preparation of Enzalutamide (I). n n n n n n n n n n The present application also relates to an improved process for the preparation of substantially pure Enzalutamide (I) having purity of greater than 99.5%. n The present application also relates to a novel process for the preparation of Enzalutamide intermediate useful in the industrially viable synthesis of Enzalutamide.

专利号:WO-2020248279-A1
优先权日:2019-06-14
标 题 :Continuous synthesis method for substituted benzoate organic matter
发明人：HONG HAO; LU JIANGPING; ZHANG ENXUAN; LIU ZHIQING; LI CHAO
权利人:JINLIN ASYMCHEM LABORATORIES CO LTD
摘要:The present invention provides a continuous synthesis method for a substituted benzoate organic matter. The continuous synthesis method comprises: in the presence of a catalyst and an organic solvent, continuously feeding an organic matter as represented by formula (I) and oxygen into a continuous reaction device for continuous oxidation reaction to obtain a substituted benzoate organic matter, and performing continuous discharge, wherein the substituted benzoate organic matter has a structure as represented by formula (II). Oxygen is a green reagent, and is cheap and easy to obtain; the present invention would not produce a large amount of waste gas, waste water, and waste residues after the completion of reaction, and the system is easy to handle. The use of continuous reaction operation can reduce the risk of solvent flash evaporation explosion due to high concentration oxygen in batch reactions. Under the same oxidation conditions, the use of a continuous preparation process can reduce the escape of oxygen, greatly increase the utilization of oxygen, simplify the operation, and improve the reaction safety and the yield of substituted benzoate organic matters.

专利号:US-2024400552-A1
优先权日:2016-11-11
标题 :Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11622968-B2
优先权日:2011-03-08
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).