CAS: 107873-03-0; 2,2-Difluorocyclopropanecarboxylic Acid

相似化合物

1883301-82-3 1631747-25-5 509072-57-5

上下游产品

2,2-二氟环丙烷甲酸丁酯 2,2-Difluorocyclopropanecarboxylic Acid Butyl Ester 260352-79-2

(2,2-Difluorocyclopropyl)Methyl Hexanoate置于水,Potassium Hydroxide,Sodium Hypochlorite,2,2,6,6-四甲基哌啶氧化物,四丁基溴化铵,碳酸氢钠,Potassium Bromide体系中,用 二氯甲烷,水 用作溶剂,化学反应生成2,2-二氟环丙羧酸
参考文献: Preparation Of A Pyrimidinyl-3,8-Diazabicyclo[3.2.1]octanylmethanone Derivative And Salt Thereof[fr] Préparation D'Un Dérivé De Pyrimidinyl-3,8-Diazabicyclo[3.2.1]octanylméthanone Et Sel De Celui-Ci
标题: Preparation Of A Pyrimidinyl-3,8-Diazabicyclo[3.2.1]octanylmethanone Derivative And Salt Thereof[fr] Préparation D'Un Dérivé De Pyrimidinyl-3,8-Diazabicyclo[3.2.1]octanylméthanone Et Sel De Celui-Ci
摘要:制备((S)-2,2-二氟环丙基)-((1R,5S)-3-(2-((1-甲基-1H-吡唑-4-基)氨基)嘧啶-4-基)-3,8-二氮杂双环[3.2.1]辛-8-基)甲酮及其制备过程中使用的中间体的方法.

专利信息

专利号:US-12247037-B2
优先权日:2018-12-12
标题:1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4h-benzo[f][1,2,4]triazolo[4,3-A][1,4]diazepine derivatives and related compounds as vasopressin antagonists for the treatment of neuro-psychological disorders
发明人：BRANDT GARY
权利人:NEUMORA THERAPEUTICS INC
摘要:The present invention relates to 1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine derivatives and related compounds of Formula (I): wherein A, B, G, R1, R1b, RiC, R2 and X are as defined herein. The present compounds are vasopressin receptor antagonists (in particular of the Via receptor) for the treatment of neuro-psychological disorders, such as e.g. autism, anxiety, stress-related disorders, depression, schizophrenia or bipolar disorder. The present description discloses the synthesis of exemplary compounds, as well as pharmacological data thereof (e.g. pages 71 to 246; examples 1 to 49; tables 1 to 5). An exemplary compound is e.g. 8-chloro-1-(2-(5-fluoropyridin-2-yl)-2,6-diazaspiro[3.3]heptan-6-yl)-5-methyl-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine (example 1, compound no. 1).

专利号:US-12304912-B2
优先权日:2020-07-28
标 题 :Fused bicyclic RAF inhibitors and methods for use thereof
发明人：BELFIELD ANDREW; JONES CLIFFORD DAVID; MARGATHE JEAN-FRANÇOIS; COLLETTO CHIARA
权利人:JAZZ PHARMACEUTICALS IRELAND LTD
摘要:The present disclosure generally relates to improved synthesis of fused bicyclic Raf inhibitors of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof. The disclosure also relates to method of using the compound of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, for treating diseases such as cancer, including colorectal cancer.

专利号:CN-104795537-B
优先权日:2015-04-19
标 题 :A solid phase synthesis of Co2+, Cu2+ doped bismuth fluoride lithium ion battery positive electrode material and its preparation method

专利号:CN-104795539-B
优先权日:2015-04-19
标 题:A liquid-phase synthesis of Cu2+, Fe3+-doped lamellar bismuth fluoride lithium-ion battery cathode material and its preparation method

专利号:CN-104795537-A
优先权日:2015-04-19
标 题 :A solid phase synthesis of Co2+, Cu2+ doped bismuth fluoride lithium ion battery positive electrode material and its preparation method

专利号:CN-104795539-A
优先权日:2015-04-19
标题 :A liquid-phase synthesis of Cu2+, Fe3+-doped lamellar bismuth fluoride lithium-ion battery cathode material and its preparation method