CAS: 107-20-0; Chloroacetaldehyde

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CAS号621-62-5 氯乙醛缩二乙醇 | CAS号79-11-8 氯乙酸 | CAS号107-07-3 2-氯乙醇 | CAS号97-97-2 2-氯乙醛缩二甲醇 | CAS号3967-54-2 氯代碳酸乙烯酯(CEC) | CAS号79-04-9 氯乙酰氯 | CAS号1129-52-8 氯乙醛三聚物 | CAS号107-21-1 乙二醇 | CAS号107-05-1 氯丙烯 | CAS号4124-17-8 mon°Copper(II) ... | CAS号111477-17-9 咪唑并[1,2-a]吡啶-8-基甲醇 | CAS号108153-93-1 5,6-二氢苯并呋喃-7(4h)-酮 | CAS号38401-67-1 5-(4-甲氧基苯基)噻吩-2-甲醛 | CAS号342613-80-3 咪唑并[1,2-a]吡啶-7-甲醇 | CAS号496-15-1 二氢吲哚 | CAS号3581-87-1 2-甲基噻唑 | CAS号3240-94-6 4-(2-氯乙基)吗啉 | CAS号141277-73-8 4-chloro-3-hydr... | CAS号541-15-1 左旋肉碱 | CAS号406-76-8 DL-肉碱

2-氯乙醇置于sodium Hydroxide,次溴酸体系中,用 水 用作溶剂,化学反应生成氯乙醛
参考文献:N-溴乙酰胺在碱性溶液中氧化伯醇的动力学和机理
标题:N-溴乙酰胺在碱性溶液中氧化伯醇的动力学和机理
摘要:已在碱性溶液中研究了n-溴乙酰胺氧化7种伯醇的动力学.氧化的主要产物是相应的醛.对于氧化剂和醇而言,该反应是一级反应.的氧化[1,1-2 ħ 2乙醇表示不存在主要的动力学同位素效应.该速率随着氢氧根离子浓度的增加而降低.加入乙酰胺会降低反应速率.在五个不同温度下确定速率,并评估活化参数.七种醇类的氧化反应的活化焓和熵呈线性关系.次溴酸盐离子被假定为反应性氧化物质.已经提出了一种机制,该机制涉及速率确定次溴酸盐离子对醇分子的亲核攻击.
Doi:10.1039/p29830000033

专利信息

专利号:US-2022395800-A1
优先权日:2019-11-04
标题:Device for automated synthesis of oligo- and polysaccharides
发明人：SEEBERGER PETER H; DANGLAD FLORES JOSE; LE MAI HOANG KIM; PARDO VARGAS ALONSO; SLETTEN ERIC; SALWICZEK MARIO
权利人:MAX PLANCK GESELLSCHAT ZU RFERDERUNG DER WSS E V; GlycoUniverse GmbH & Co KG&A
摘要:The present invention generally relates to automated synthesis technology, and more particularly, to a device and method for automated synthesis of oligo- and polysaccharides on a solid support. In particular the present invention relates to a device for automated synthesis of oligo- and polysaccharides on a solid support comprising a reaction vessel, a reagent storing component, a reagent delivery system, a cooling device for cooling reaction vessel, and a pre-cooling device for pre-cooling the reagents to be supplied.

专利号:US-2004152905-A1
优先权日:2003-01-31
标题:Universal building blocks and support media for synthesis of oligonucleotides and their analogs
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and chemically modified oligonucleotide analogs, are provided. In addition, methods for functionalization of a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-2004242897-A1
优先权日:2002-07-31
标题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-7230101-B1
优先权日:2002-08-28
标 题:Synthesis of methotrexate-containing heterodimeric molecules
发明人：MURTHI KRISHNA K; SMITH CHASE C
权利人:GPC BIOTECH INC
摘要:The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:

专利号:US-2004058888-A1
优先权日:2000-01-13
标题:Methods for synthesis of alpha-d-gal (1~>3) gal-containing oligosaccharides
发明人：BORNAGHI LAURENT; DEKANY GYULA; DRINNAN NICHOLAS BARRY; PAPAGEORGIOU JOHN; WEST MICHAEL LEO
摘要:This invention relates to reagents and methods for synthesis of biologically active di- and tri-saccharides comprising α-D-Gal(1→3)-D-Gal. In particular the invention provides novel reagents, intermediates and processes for the solution or solid phase synthesis of α-D-galactopyranosyl-(1→3)-D-galactose, and derivatives thereof. In one preferred embodiments the invention provides a protected monosaccharide building block of general formula (II): in which R 3 is methoxy or methyl; R 1 is H, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4-chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl; and R 2 is H, Fmoc, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4 -chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl.

专利号:US-2004018598-A1
优先权日:2000-05-30
标题 :Bio-intermediates for use in the chemical synthesis of polyketides
发明人：SANTI DANIEL; ASHLEY GARY; MYLES DAVID C
摘要:The present invention relates to compounds made by a subset of modules from one or more polyketide synthase (“PKSâ€?) genes that are used as starting material in the chemical synthesis of novel molecules, particularly naturally occurring polyketides or derivatives thereof. The biologically derived intermediates (“bio-intermediatesâ€?) generally represent particularly difficult compounds to synthesize using traditional chemical approaches due to one or more stereocenters. In one aspect of the invention, an intermediate in the synthesis of epothilone is provided that feeds into the synthetic protocol of Danishefsky and co-workers. In another aspect of the invention, intermediates in the synthesis of discodermolide are provided that feed into the synthetic protocol of Smith and co-workers. By taking advantage of the inherent stereochemical specificity of biological processes, the syntheses of key intermediates and thus the overall syntheses of compounds like epothilone and discodermolide are greaty simplified.