CAS: 104706-47-0; (R)-3-Hydroxypyrrolidine Hydrochloride

相似化合物

2799-21-5 86070-82-8 122536-94-1

上下游产品

(3R)-N-acetyl-3-(tert-butyldimethylsilyloxy)propylamine 4R-4-hydroxyproline 2-chloro-5-trifluoromethylpyridine p-toluenesulfonyl chloride (3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester 3-(R)-hydroxy-1-(N-p-nitrobenzyloxycarbonylacetimidoyl)pyrrolidine (3R)-3-hydroxy-1-(4-nitrobenzyloxycarbonyl)-pyrrolidine (R)-3-Hydroxy-pyrrolidine-1-carboxylic acid ((R)-1-benzyl-pyrrolidin-3-yl)-methyl-amide

L-羟基脯氨酸置于盐酸体系中,用 Cyclohexene-1-One,2-,环己醇,乙醇 用作溶剂,化学反应 11.0H,以35%的收率获得(R)-3-羟基吡咯烷盐酸盐
参考文献: 1-Substituted-3-Pyrrolidine Derivatives As Muscarinic Receptor Antagonists[fr] Derives De 1-Substitues-3-Pyrrolidines Comme Antagonistes De Recepteurs Muscariniques
标题: 1-Substituted-3-Pyrrolidine Derivatives As Muscarinic Receptor Antagonists[fr] Derives De 1-Substitues-3-Pyrrolidines Comme Antagonistes De Recepteurs Muscariniques
摘要:这项发明通常涉及具有式(i)结构的1-取代-3-吡咯啉二烯衍生物:本发明的化合物可以作为..毒蕈碱受体拮抗剂,可用于治疗通过毒蕈碱受体介导的呼吸系统,泌尿系统和消化系统的各种疾病.该发明还涉及制备本发明化合物的方法,含有本发明化合物的药物组合物以及治疗通过毒蕈碱受体介导的疾病的方法.

专利信息

专利号:US-7153960-B2
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
发明人：ZHOU JIACHENG; OH LYNETTE M; MA PHILIP; LI HUI-YIN; CONFALONE PASQUALE
权利人:BRISTOL MYERS SQUIBB CO
摘要:A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. n nThese compounds are useful as factor Xa inhibitors.

专利号:US-2003181466-A1
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones

专利号:US-2005245566-A1
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones

专利号:US-8030501-B2
优先权日:2006-07-28
标题 :Process for producing optically active 3-amino nitrogen-containing compounds
发明人：OHNUKI MASATOSHI; IZUMIDA MASASHI; NISHIYAMA AKIRA; MATSUMOTO SHINGO
权利人:KANEKA CORP
摘要:Aiming at production of an optically active 3-amino nitrogen-containing compound which is useful as an intermediate in synthesis of medicines and pesticides, in particular, an optically active 1-protected-3-aminopyrrolidine derivative, from an inexpensive and readily available raw material by a process which is efficient and can be practiced industrially, an optically active 3-amino nitrogen-containing compound is produced by performing a reaction of an optically active 3-substituted nitrogen-containing compound with ammonia, methylamine, ethylamine or dimethylamine in the presence of water. In addition, a 1-protected-3-aminopyrrolidine derivative is produced by performing a reaction of an optically active 1-protected-3-(sulfonyloxy)pyrrolidine derivative with ammonia, methylamine, ethylamine, or dimethylamine in the presence of methanol, ethanol, n-propanol, or isopropanol under a pressure of less than 30 barr.

专利号:CN-1639147-A
优先权日:2001-12-10
标题 :Synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyridin-2-ones

专利号:US-2007027186-A1
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones