CAS: 104091-08-9; (R)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-5-(Tert-Butoxy)-5-Oxopentanoic Acid

该化合物是一种受保护的氨酸甘酸基甲基酸,其特点是氟辛基碳酸(Fmoc),它通常用于浸泡合成,以保护氨基组,允许在碳箱基体组中作出选择性反应. 异丁基酯(OtBu)保护碳箱酸功能,增强化合物的稳定性和溶解性.这种物质通常是白的,是非白的固体,在二氯甲烷和二甲基甲基芳基胺等有机溶剂中溶解,但水中溶解较少.由于能够促进氨酸的相继添加,同时防止不受欢迎的侧反应.在各种条件下,该化合物在生物合成中具有宝贵的中间体,并且在其他条件下,该化合物在生物合成中具有生命力的分子.

结构式图片

相似化合物

71989-18-9 104719-63-3 13726-84-6

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合成工艺路线路线简述

    Fmoc-D-葡萄糖苄基酯置于palladium On Activated Charcoal 硫酸,Ammonium Formate体系中,用 四氢呋喃,甲醇,二氯甲烷 用作溶剂,25.0 °C,199.94 Kpa 条件下,反应 6.33H,反应生成N-芴甲氧羰基-D-谷氨酸 Gamma-叔丁酯
    参考文献:Synthesis Of (R)-And (S)-(Glu)Thz And The Corresponding Bisthiazole Dipeptide Of Dolastatin 3
    标题:Synthesis Of (R)-And (S)-(Glu)Thz And The Corresponding Bisthiazole Dipeptide Of Dolastatin 3
    摘要:
    Doi:10.1021/jo00374A019

    海关参考信息

    专利信息


    专利号:US-5817751-A
    优先权日:1994-06-23
    标 题 :Method for synthesis of diketopiperazine and diketomorpholine derivatives
    发明人:SZARDENINGS ANNA KATRIN; CAMPBELL DAVID
    权利人:AFFYMAX TECH NV
    摘要:The present invention relates to the areas of organic and medicinal chemistry. More specifically, the present invention is concerned with combinatorial and solid phase methods for the synthesis of diverse diketopiperazine derivatives, and the use of such methods to create libraries of diverse diketopiperazine derivatives. The present invention has application in the areas of chemical synthesis, the screening for new diketopiperazine derivatives having beneficial medical properties and the use of such screening to provide compositions and methods including diketopiperazine derivatives for treating disease.

    专利号:CN-115925790-A
    优先权日:2016-03-23
    标 题:Method for the synthesis of α4β7 peptide antagonists

    专利号:US-11879038-B2
    优先权日:2019-09-09
    标 题 :Supramolecular gel supported on open-cell polymer foam
    发明人:JIERRY LOÃ?C; SERRA CHRISTOPHE; SCHAAF PIERRE; RODON FORES JENNIFER; BOULMEDAIS FOUZIA
    权利人:UNIV STRASBOURG; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED
    摘要:The present invention relates to a polymer foam, said polymer foam comprising pores forming an open-cell polymer foam, said polymer foam comprising a supramolecular gel inside pores, and said polymer foam comprising at least one enzyme. The present invention relates to a supramolecular gel; its preparation and its applications, notably in chemical synthesis and kinetic resolution, in particular of organic compounds. The present invention also relates to flow chemistry.

    专利号:CN-118085036-B
    优先权日:2022-11-25
    标题 :An amphiphilic D/L cyclic peptide capable of self-assembly to form a nanohelix and a synthesis and assembly method thereof
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    主要参考文献

    [参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

    合成参考文献

    合成方法参考DOI号:10.1021/jo00374a019
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