CAS: 918525-02-7; 3-Bromo-1-(Triisopropylsilyl)-1H-Pyrrolo[2,3-B]Pyridine

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640735-24-6 858116-66-2 685513-91-1

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3-bromo-1H-pyrrolo[2,3-b]pyridine triisopropylsilyl chloride 1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine

📜3-溴-7-氮杂吲哚,三异丙基氯硅烷置于sodium Hydride体系中,用 四氢呋喃 作为反应溶剂,以97%的收率获得产物3-溴-1-[三(1-甲基乙基)硅基]-1H-吡咯并[2,3-B]吡啶
参考文献:A Closer Look At The Bromine-lithium Exchange With Tert-Butyllithium In An Aryl Sulfonamide Synthesis
标题:A Closer Look At The Bromine-lithium Exchange With Tert-Butyllithium In An Aryl Sulfonamide Synthesis
摘要:A Practical Protocol For The One-Pot Synthesis Of Various Aryl Sulfonamides,Notably Of Pyridine-Core-Substituted 7-Azaindolyl Sulfonamides,Is Described. A Key Step Is The Well-Known Bromine-Lithium Exchange Reaction Of An Aryl Bromide With Tert-Butyllithium (T-Buli). Differing From The Common Practice To Use 2 Or More Equiv Of Organolithium,The Exact Amount Of T-Buli Needed For A Sufficient Exchange Reaction Is Determined For Each Aryl Bromide In A Gc-Ms-Assisted Experiment.
DOI:10.1021/ol4010454