CAS: 84957-29-9; Cefpirome

上下游产品

CAS号63527-52-6 头孢噻肟 | CAS号533-37-9 2,3-环戊烯并吡啶 | CAS号104146-10-3 7-苯乙酰氨基-3-氯甲基-4... | CAS号83421-24-3 7β-[2-(2-aminot... | CAS号86070-92-0 (6R,7R)-7-((Z)-... | CAS号98753-19-6 硫酸头孢匹罗 | CAS号533-37-9 2,3-环戊烯并吡啶 | CAS号104301-63-5 (Z)-2-氨基-alpha-...

(6R,7R)-3-((6,7-Dihydro-5H-Cyclopenta[b]Pyridin-1-Ium-1-yl)Methyl)-8-Oxo-7-(2-Phenylacetamido)-5-Thia-1-Azabicyclo[4.2.0]oct-2-Ene-2-Carboxylate置于青霉素(酰胺)酶体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 6.5H,反应生成 头孢匹罗
参考文献:One-Pot Synthesis Of Cefpirome Sulfate From Gcle
标题:One-Pot Synthesis Of Cefpirome Sulfate From Gcle
摘要:[image Omitted] Cefpirome Was Synthesized In 37.7% Overall Yield From 3-Chloromethyl-7-Phenylacetylamino Cephalosporanic Acid P-Methoxybenzyl Ester (Gcle) By Sequential Substitution Of C-3 Chloride With Iodide And 2,3-Cyclopentenopyridine,Followed By A One-Pot Procedure Including Deprotection Of Carboxyl Group,Hydrolysis Of 7-Phenylacetamido,And Reaction With 2-Mercaptobenzothiazolyl-(Z)-2-(2-Aminothiazol-4-yl)-2-Methoxyiminoacetate (Maem). The Reaction Conditions Were As Follows: Obtained From Gcle At Low Temperature (-5 To 0 Degrees C) And Absence Of Light,3-Iodomethyl-7-Phenylacetylamino Cephalosporanic Acid P-Methoxybenzyl Ester (Gile) Without Purification Was Reacted Directly With 2,3-Cyclopentenopyridine,In Which The Molar Ratio Of Gcle,Nai,And 2,3-Cyclopentenopyridine Was 1:2:4,And The Molar Ratio Of The Resulting Compound P-Methoxybenzyl 7-Phenylacetylamido-3-(2,3-Cyclopenteno-1-Pyridinio)Methyl-3-Cephem-4-Carboxylate Iodide And Maem Was 1:1.1. The Structure Of The Intermediate And The Target Compound Obtained Were Determined By Nuclear Magnetic Resonance Spectra And Mass Spectroscopy.
DOI:10.1080/00397911003629499

专利信息

专利号:US-8017776-B2
优先权日:2003-07-15
标题 :Methods for synthesis of acyloxyalkyl compounds
发明人：BHAT LAXMINARAYAN; GALLOP MARK A
权利人:XENOPORT INC
摘要:Disclosed herein are methods for synthesizing 1-(acyloxy)-alkyl prodrug derivatives of drugs through oxidation of 1-acyl-alkyl derivatives of drugs under anhydrous reaction conditions. The methods typically proceed stereospecifically, in high yield, do not require the use of activated intermediates and/or toxic compounds and are readily amenable to scale-up.

专利号:WO-2012095438-A1
优先权日:2011-01-12
标 题 :Particles and suspensions of cephalosporin antibiotics
发明人：NIEDERMANN HANS PETER; BOTHE HEIKO
权利人:INTERVET INT BV; NIEDERMANN HANS PETER; BOTHE HEIKO
摘要:Disclosed is a method of making particles of a cephalosporin antibiotic, particularly cefquinome, wherein use is made of diafiltration. The diafiltration can be with anti- solvent, in which case a precipitate is obtained of particles as such. The diafiltration can also be with a pharmaceutically acceptable suspension medium. In that case several process steps of isolating, drying, transporting of particles can be avoided, because the suspension resulting from the synthesis of the particles is directly turned into a final drug product formulation.

专利号:US-9066864-B2
优先权日:2011-01-12
标 题:Use of liquid medium exchange by cross flow filtration in the preparation of drug suspensions
发明人：NIEDERMANN HANS PETER; BOTHE HEIKO
权利人:NIEDERMANN HANS PETER; BOTHE HEIKO; INTERVET INC
摘要:Disclosed is a method of making particles of a drug wherein use is made of diafiltration. The diafiltration can be with anti-solvent, in which case a precipitate is obtained of particles as such. The diafiltration can also be with a pharmaceutically acceptable suspension medium. In that case several process steps of isolating, drying, transporting of particles can be avoided, because the suspension resulting from the synthesis of the particles is directly turned into a final drug product formulation.

专利号:US-8143437-B2
优先权日:2002-02-19
标题:Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
发明人：GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X
权利人:GALLOP MARK A; XIANG JIA-NING; YAO FENMEI; BHAT LAXMINARAYAN; ZHOU CINDY X; XENOPORT INC
摘要:The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amendable to scale-up. The current invention also provides 1-acyl-alkyl derivatives of known drug components and methods for synthesizing these 1-acyl-alkyl derivatives.

专利号:US-7452990-B2
优先权日:2002-12-26
标题 :Intermediates for synthesis of cephalosporins and process for preparation of such intermediates
发明人：DATTA DEBASHISH; DANTU MURALIKRISHNA; MISHRA BRIJKISHORE; SHARMA POLLEPEDDI LAKSHMI NARAYANA
权利人:LUPIN LTD
摘要:A novel 4-halo-2-oxyimino-3-oxo butyric acid-N,N-dimethyl formiminium chloride chlorosulfate of formula (I) useful in the preparation of cephalosporin antibiotics n nwhereinn n X is chlorine or bromine; R is hydrogen, C 1-4 alkyl group, an easily removable hydroxyl protective group, —CH 2 COOR 5 , or —C(CH 3 ) 2 COOR 5 , wherein R 5 is hydrogen or an easily hydrolysable ester group. The compound of formula (I) is prepared by reacting 4-halo-2-oxyimino-3-oxobutyric acid of formula (IV 1 ), n nwherein X, R and R 5 are as defined above, with N,N-dimethylformiminium chloride chlorosulphate of formula (VII)n n nin an organic solvent at a temperature ranging from −30° C. to −15° C. The cephalosporins that may be prepared from the intermediate include cefdinir, cefditoren pivoxil, cefepime, cefetamet pivoxil, cefixime, cefmenoxime, cefodizime, cefoselis, cefotaxime, cefpirome, cefpodoxime proxetil, cefquinome, ceftazidime, cefteram pivoxil, ceftiofur, ceftizoxime, ceftriaxone and cefuzonam.

专利号:US-9006421-B2
优先权日:2013-03-14
标题 :Cephalosporin compositions and methods of manufacture
发明人：LAI JAN-JI; PATHARE PRADIP M; KOLLA LAXMA; SORET ADRIEN F
权利人:CUBIST PHARM INC
摘要:Provided herein is a method for the synthesis of cephalosporin antibiotic compounds comprising the conversion of a protected 7-amino group into a 7-carboxamide moiety in a single step.