CAS: 738-99-8; Antineoplastic Agent-1
该化合物是一种化学化合物,其独特的结构包括一个管子环和两个(1-aziridinyl) 硫磺基组;该化合物在医药化学和作为离子体和协调化学中的潜在应用由于磷和氮功能的存在而引人注目;环有助于其再活动,使其成为各种化学变异的候选物;此外,磷在结构中的存在可能具有有趣的特性,例如潜在的生物活动和与金属形成复合体的能力;该化合物通常通过多步有机反应合成,其稳定性,溶解性和再活性可能因处理该化合物的具体条件而不同.与许多含有磷的化合物一样,在使用和处置过程中必须考虑安全和环境因素.
- 英文名称Antineoplastic Agent-1
- 中文名称1,4-二(N,N'-二亚乙基磷酰胺)哌嗪
- IUPAC名称piperazine-1,4-diylbis(di(aziridin-1-yl)phosphine oxide)
- 其它别名1,4-Bis(N,N'-Diethylene Phosphamide)Piperazine; Dipin; 1,4-Piperazinedihylbis(Bis(1-Aziridinyl)-Phophineoxide; Phosphineoxide,1,4-Piperazinediylbis(Bis(1-Aziridinyl)-; 1,4-Piperazinediylbis[bis(1-Aziridinyl)Phosphine Oxide]; Dipine; Piperazine, 1,4-Bis[bis(1-Aziridinyl)Phosphinyl]-
- CAS编号738-99-8
- MFCD编号:MFCD00405583
- FDA UNII编号:L16KNK08VM
- 分子式:C12H24N6O2P2分子量:346.31
- 产品CID: 2729390
- 产品分类有机原料 → 有机杂环化合物 → 二嗪烷类
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2921211000-乙二胺
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专利信息
专利号:CN-114989072-A
优先权日:2022-05-27
标 题:A method for asymmetric catalytic synthesis of chiral 1,4-dihydropyridine compounds and its application
专利号:CN-101691351-A
优先权日:2009-09-30
标题 :Synthesis of 4-aminopropenylphenyl-1,4-dihydropyridines and their medicinal uses
专利号:CN-101691351-B
优先权日:2009-09-30
标 题:Synthesis method of 4-aminopropenylphenyl-1,4-dihydropyridine and medicinal application thereof
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
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主要参考文献
1: Factor VM, Radaeva SA, Thorgeirsson SS. Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse. Am J Pathol. 1994 Aug;145(2):409-22.
2: Uryvaeva IV. Model' repopuliatsii pecheni, povrezhdennoĭ dipinom [A model of regeneration of the liver damaged by dipin]. Biull Eksp Biol Med. 1997 Oct;124(10):364-8. Russian. 28(2):537-46. doi: 10.1002/hep.510280235. 21(3):262-6. Russian. 33(2):187-97. doi: 10.1007/BF02899181. 20(4):307-11. Russian. 24(10):1891. doi: 10.3390/molecules24101891.
8: Domaratskaia EI, Bueverova EI, Paiushina OD, Starostin VI. [Alkylating damage by dipin of hematopoietic and stromal cells of the bone marrow]. Izv Akad Nauk Ser Biol. 2005 May-Jun;(3):267-72. Russian. (3):272-82. Russian.
合成参考文献
摘要:Pharmaceutical Chemistry Journal, 14(363), 1980
摘要:PETROV KIa. [Dipin in the treatment of chronic lympholeukemia]. Ter Arkh. 1961 Feb;33():102–7.
摘要:KLVANA M. [Experimental clinical experiences with a new cytostatic drug Dipin in the treatment of ovarian carcinoma]. Neoplasma. 1960;7(Suppl 1)():149–52.
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