欧盟法规
ECHA物质C&L通报上下游产品
16H19OPC16H19OP bis(3,5-dimethylphenyl)phosphine oxide (3,5-dimethylphenyl)lithium 5-bromo-1,3-xylene(+/-)-(1-dibenzophospholylmethyl-1-di(3,5-dimethylphenyl)phosphinylmethyl)-1-diphenylphosphinyl-methylethane -1-chlor-2-(diphenylphosphanylmethyl)propan2--1-chlor-2-(diphenylphosphanylmethyl)propan (S)-1-[Bis-(3,5-dimethyl-phenyl)-phosphanyl]-3-diphenylphosphanyl-propan-2-ol 合成工艺路线路线简述
- 合成目标产物 Bis(3,5-Dimethylphenyl)Phosphine 主要起始原料 (Xyl)2P(O)H
- (文献来源)合成步骤主要原料 (Xyl)2P(O)H
专利信息
专利号:US-7495123-B2
优先权日:2004-04-05
标 题:Process for the preparation of enantiomerically enriched beta amino acid derivatives
发明人:XIAO YI; SUN YONGKUI; ROSNER THORSTEN; RIVERA NELO R; KRSKA SHANE W; CLAUSEN ANDREW M; ARMSTRONG III JOSEPH D; SPINDLER FELIX; MALAN CHRISTOPHE
权利人:SOLVIAS AG; MERCK & CO INC
摘要:The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives wherein the amino group is unprotected. The product chiral beta amino acid derivatives are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of an amine-unprotected prochiral beta-amino acrylic acid or derivative thereof in the presence of a rhodium metal precursor complexed with a chiral mono- or bisphosphine ligand.
专利号:WO-2025096445-A1
优先权日:2023-10-30
标题:Synthesis of intermediates for the preparation of macrocyclic compounds
发明人:CHOI YOUNGGI; HUYNH HOAN
权利人:ALKERMES INC
摘要:Provided are methods for synthesizing intermediates useful in the preparation of compounds having activity against orexin-2 receptor.
专利号:ES-2404827-T3
优先权日:2008-12-18
标 题:Procedure for the synthesis of aminomethyl-tetralin derivatives
专利号:US-9062085-B2
优先权日:2010-09-10
标 题 :Biaryl diphosphine ligands, intermediates of the same and their use in asymmetric catalysis
发明人:ABDUR-RASHID KAMALUDDIN; JIA WENLI; LU SHUIMING; GUO RONGWEI; CHEN XUANHUA; AMOROSO DINO
权利人:ABDUR-RASHID KAMALUDDIN; JIA WENLI; LU SHUIMING; GUO RONGWEI; CHEN XUANHUA; AMOROSO DINO; KANATA CHEMICAL TECHNOLOGIES INC
摘要:The present disclosure relates to biaryl diphosphine ligands of the formula (B), processes for the production of the ligands and the use of the ligands in metal catalysts for asymmetric synthesis. The disclosure also relates to intermediates used for the production of the biaryl diphosphine ligand. (Formula (B))
专利号:CN-109843870-A
优先权日:2016-10-19
标 题:Synthesis of EZH2 Inhibitors
专利号:CA-2743978-C
优先权日:2008-12-18
标 题 :Process for synthesis of amino-methyl tetraline derivatives