专利号:US-6005097-A 优先权日:1996-06-14 标题 :Processes for high-yield diastereoselective synthesis of dideoxynucleosides 发明人:CHEN SHU-HUI; LI XIUYAN 权利人:VION PHARMACEUTICALS INC 摘要:The present invention relates to methods for substantially enhancing the stereoselective synthesis of β-anomeric nucleoside analogs. In methods according to the present invention, the introduction of a phenylseleno group onto a blocked lactone sugar precursor may be selected so that the desirable phenylseleno substituent is introduced on the side of the blocked lactone away from the blocking group. This stereospecific introduction of the phenylseleno group in sugar precursor allows the synthesis of nucleoside analogs and in particular, 2',3',-dideoxy- and 2',3'-dideoxy-2',3'-didehydronucleoside analogs in very high yield. In certain preferred embodiments, the preferred phenylseleno blocked lactone is obtained in an amount representing approximately 90% or more of the total amount of the stereoisomers obtained. In even more preferred embodiments, the amount of the preferred stereoisomer is at least 95%, even more preferably at least about 97% of the total amount of phenylseleno blocked lactone produced.
专利号:US-7968734-B2 优先权日:2004-07-01 标 题 :Organocatalysts and methods of use in chemical synthesis 发明人:WANG WEI; WANG JIAN; LI HAO 权利人:STC UNM 摘要:The present invention pertains generally to compositions comprising organocatalysts that facilitate stereo-selective reactions and the method of their synthesis and use. Particularly, the invention relates to metal-free organocatalysts for facilitation of stereo-selective reactions, and the method of their synthesis and use.
专利号:WO-9747635-A1 优先权日:1996-06-14 标 题:Processes for high-yield diastereoselective synthesis of dideoxynucleosides
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专利号:US-2012142911-A1 优先权日:2009-06-12 标题:Synthesis of ttx intermediates
专利号:JP-2000512637-A 优先权日:1996-06-14 标 题:High yield diastereoselective synthesis of dideoxynucleosides