Dl-酪氨酸置于吡啶,氯化亚砜,三乙胺体系中,化学反应生成 Boc-D-酪氨酸 参考文献:Turan; Bajusz,Acta Chimica Academiae Scientiarum Hungaricae,1981,Vol. 107,# 1,P. 7-9 标题:Turan; Bajusz,Acta Chimica Academiae Scientiarum Hungaricae,1981,Vol. 107,# 1,P. 7-9
专利号:WO-2010077155-A1 优先权日:2008-12-31 标 题 :A method of producing an n-blocked peptide 发明人:LIPKOWSKI ANDRZEJ 权利人:ACTION FOR DEV OF RES SP Z O O; LIPKOWSKI ANDRZEJ 摘要:The perspective uses of using peptides as drags require economical synthesis methods. It was shown that N-blocked peptide derivatives constituting the raw material for use in peptide synthesis may be obtained through the modification of the synthesis, which is based on the acylation of an appropriate organic amino-acid salt using an appropriate active derivative of an amino-acid or peptide.
专利号:US-2014309424-A1 优先权日:2011-06-30 标题:Direct synthesis of 18f-fluoromethoxy compounds for pet imaging and the provision of new precursors for direct radiosynthesis of protected derivatives of o-([18f] fluoromethyl) tyrosine 发明人:BRUMBY THOMAS; GRAHAM KEITH; KRUGER MARTIN 权利人:BRUMBY THOMAS; GRAHAM KEITH; KRUGER MARTIN; PIRAMAL IMAGING SA 摘要:The invention describes novel direct synthesis methods for converting a precursor into a PET-tracer with a 18 F-fluoromethoxy-group. The invention is also directed to novel and stable precursors for the direct radiosynthesis of protected derivatives of O—([ 18 F]Fluoromethyl)tyrosines.
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-5783577-A 优先权日:1995-09-15 标题 :Synthesis of quinazolinone libraries and derivatives thereof 发明人:HOUGHTEN RICHARD A; OSTRESH JOHN M 权利人:TREGA BIOSCIENCES INC 摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.
专利号:WO-9710221-A1 优先权日:1995-09-15 标 题:Synthesis of quinazolinone libraries 发明人:HOUGHTEN RICHARD A; OSTRESH JOHN M 权利人:TORREY PINES INST 摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.
专利号:US-6989401-B2 优先权日:2000-07-19 标题:Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products 发明人:MAEDA KAZUHIRO; SONDA SHUJI; TAKEMOTO TADAHIRO; GOTO TOMOKAZU; KOBAYASHI FUJIO; KAJII MASAHIKO; KOMORITA NARUYASU; HIRAYAMA FUMIHIRO 权利人:MITSUBISHI PHARMA CORP 摘要:The present invention relates to a novel sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof. More particularly, the present invention relates to a sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof, which is useful as an inhibitor of lipopolysaccharides (LPS). In addition, the present invention relates to a novel intermediate compound useful for the synthesis of this sulfonic acid derivative of hydroxamic acid.
[参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
合成参考文献
参考文献:10.1055/s-2006-958931 摘要:Li M, Zhou P, Roth H. An Effective Route to (-)-Aphanorphine Using d-Tyrosine as a Chiral Building Block. Synthesis. 2007 Jan;2007(1):55–60. doi: 10.1055/s-2006-958931. 参考文献:10.1055/s-0030-1260561 摘要:Buckley B, Page P, McKee V. A Rapid and Highly Diastereoselective Synthesis of Enantiomerically Pure (4R,5R)- and (4S,5S)-Isocytoxazone. Synlett. 2011 May 13;2011(10):1399–402. doi: 10.1055/s-0030-1260561.