CAS: 694-05-3; 3-Piperideine

该化合物是一种循环有机化合物,其特点是五人环状结构,内含一个氮原子和四个碳原子;一种无色的黄色液体,具有一种与地雷相似的独特气味;该化合物因其基本性而闻名于其存在,因为氮原子可以参与质子反应;可溶于水和有机溶剂,使其具有多种用途的灵巧性;1,2,3,6-四氢丙烯经常被用作有机合成的构件,特别是在制药和农用化学方面;此外,它可以作为结扎和化学协调的构件,并参与复杂含氮化合物的合成;其再活动包括进行氧化和减少反应,这可能导致产生各种衍生物;安全考虑因素应当加以考虑,因为接触时可能对健康造成危害,因此需要适当的处理和储存规程.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号2589-31-3 Pyridinium,1-(p... | CAS号2876-13-3 氯化-1-(苯甲基)吡啶翁 | CAS号40240-12-8 N-苄基-1,2,3,6-四氢吡啶 | CAS号52003-32-4 ethyl 3,6-dihyd... | CAS号462-08-8 3-氨基吡啶 | CAS号110-86-1 吡啶 | CAS号100-39-0 溴化苄 | CAS号85839-08-3 1-cyano-1,2,3,6... | CAS号694-55-3 1-甲基-1,2,3,6-四氢吡啶 | CAS号37656-48-7 4-(4-氟苯基)哌啶 | CAS号104774-88-1 4-(3-氟苯基)-哌啶 | CAS号180161-17-5 4-(2-氟苯基)哌啶 | CAS号18513-75-2 Ethanone,1-(3,6... | CAS号18065-78-6 1-phenethylpyri... | CAS号26905-02-2 4-(4-氯苯基)哌啶 | CAS号100129-35-9 4-(2-氯苯基)哌啶 | CAS号99329-53-0 4-(3-氯苯基)哌啶 | CAS号85838-94-4 1-B°C-1,2,3,6-四氢吡啶 | CAS号771-99-3 4-苯基哌啶

合成工艺路线路线简述

    📜1,2,3,6-四氢-1-(苯基甲基)吡啶置于氢氧化钾,一水合肼体系中,用 乙二醇,苯 作为反应溶剂,化学反应 2.5H,反应生成 1,2,3,6-四氢吡啶
    参考文献:新型含取代哌啶的氟喹诺酮类化合物的合成和抗菌活性.
    标题:新型含取代哌啶的氟喹诺酮类化合物的合成和抗菌活性.
    摘要:描述了在c-7位具有取代哌啶环的新型氟喹诺酮类抗菌剂的设计和合成.大多数新化合物显示出很高的体外抗菌活性.它们中的几个对革兰氏阳性生物体显示出显着的活性,其活性比吉西沙星,利奈唑胺和万古霉素强.
    DOI:10.1016/j.Bmcl.2007.05.093

    海关参考信息

    专利信息


    专利号:US-2008086013-A1
    优先权日:2006-06-15
    标 题:Carbometallation of alkynes and improved synthesis of uniquinones
    发明人：LIPSHUTZ BRUCE H
    权利人:UNIV CALIFORNIA
    摘要:Methods for the carbometallation of alkynes are presented. Those are useful for the synthesis of CoQ 10 and other ubiquinones as well as for the synthesis of ubiquinol analogs.

    专利号:US-2004266827-A1
    优先权日:2003-06-25
    标 题 :Convergent asymmetric route to produce a key intermediate towards the synthesis of a garft inhibitor
    发明人：NOTZ WOLFGANG REINHARD LUDWIG; MARTINEZ CARLOS ALBERTO
    权利人:AGOURON PHARMA
    摘要:The invention relates to processes for the preparation of a key intermediate in the synthesis of a GARFT inhibitor of formula (Ia) containing a 4-methyl-substituted thiophene core: n n n wherein said key intermediate has the following formula (I): n n n wherein each of R 1 and R 2 are independently a moiety that together with the attached CO 2 forms a readily hydrolyzable ester group; n from a compound of the formula (VI): n n n wherein R 1 is as described above, Pg 1 is an amino protecting group, and Pg 2 is an ether protecting group; wherein said processes are as described in the specification.

    专利号:US-2003083352-A1
    优先权日:2000-07-31
    标 题 :Synthesis of imidazole intermediates
    发明人：HELAL CHRISTOPHER J
    权利人:PFIZER
    摘要:The invention provides a method for synthesis of compounds of formula n n n wherein R 1 and R 19 are as defined. Compounds of formula 12 are useful as intermediates for synthesizing compounds having pharmacological activity inhibiting cdk5, cdk2, and GSK-3.

    专利号:US-7138526-B1
    优先权日:1999-06-15
    标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
    发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
    权利人:AVENTIS PHARMA INC
    摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

    专利号:US-2007260076-A1
    优先权日:2003-12-05
    标 题:Practical, Cost-Effective Synthesis of Ubiquinones
    发明人：LIPSHUTZ BRUCE H; BERL VOLKER; SHEIN KARIN; WETTERICH FRANK
    权利人:LIPSHUTZ BRUCE H; BERL VOLKER; SHEIN KARIN; WETTERICH FRANK
    摘要:The present invention provides a convergent method for the synthesis of ubiquinones and ubiquinone analogues. Also provided are precursors of ubiquinones and their analogues that are useful in the methods of the invention. The invention further provides an improved method for the carboalumination of alkyne substrates.

    专利号:US-2006167289-A1
    优先权日:2003-12-05
    标题 :Practical, cost-effective synthesis of ubiquinones
    发明人：LIPSHUTZ BRUCE H; BERL VOLKER; SCHEIN KARIN; WETTERICH FRANK
    权利人:ZYMES LLC
    摘要:The present invention provides a convergent method for the synthesis of ubiquinones and ubiquinone analogues. Also provided are precursors of ubiquinones and their analogues that are useful in the methods of the invention. The invention further provides an improved method for the carboalumination of alkyne substrates.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Chiral Synthesis Via Organoboranes. 6. Hydroboration. 74. Asymmetric Hydroboration Of Representative Heterocyclic Olefins With Diisopinocampheylborane. Synthesis Of Heterocyclic Boronates And Heterocyclic Alcohols Of Very High Enantiomeric Purity
    作者:Herbert C. Brown,J. V. N. Vara. Prasad |发布日期:1986.4
    摘要:Etude De La Borhydratation De Dihydrofurannes, -Thiophenes, -Pyrannes Et -Thiopyrannes Et De Pyrrolines Et Tetrahydropyridines: Obtention Des Heterocycles Perhydrogenes Correspondants Hydroxyles Et Diethoxyboryles En 3; Reactions De Ces Derniers Avec La Diethanolamine Et Obtention D'Amine-Boranes Internes Derives D'Heteryl-2 Perhydro Dioxazaborocines-1,3,6,2

    合成参考文献


    摘要:Li, G.; Szostak, M., Science of Synthesis Knowledge Updates, (2020) 2, 222.
    参考文献:10.1007/bf03033169
    摘要:Aguilar Hernández R, Sánchez De Las Matas MJ, Arriagada C, Barcia C, Caviedes P, Herrero MT, Segura-Aguilar J. MPP(+)-induced degeneration is potentiated by dicoumarol in cultures of the RCSN-3 dopaminergic cell line. Implications of neuromelanin in oxidative metabolism of dopamine neurotoxicity. Neurotox Res. 2003;5(6):407–10. doi: 10.1007/bf03033169.
    参考文献:10.1007/s00203-006-0157-x
    摘要:Kim YH, Kang I, Bergeron H, Lau PC, Engesser KH, Kim SJ. Physiological, biochemical, and genetic characterization of an alicyclic amine-degrading Mycobacterium sp. strain THO100 isolated from a morpholine-containing culture of activated sewage sludge. Arch Microbiol. 2006 Nov;186(5):425–34. doi: 10.1007/s00203-006-0157-x.
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