CAS: 635-21-2; 2-Amino-5-Chlorobenzoic Acid

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2,5-二氯苯甲酸置于n,N-二甲基甘氨酸,氨,Copper(L) Chloride体系中,用 N,N-二甲基乙酰胺 作为反应溶剂,化学反应 8.0H,以96.2%的收率获得产物2-氨基-5-氯苯甲酸
参考文献:一种5-氯-2-氨基苯甲酸中间体的制备方法
标题:一种5-氯-2-氨基苯甲酸中间体的制备方法
摘要:本发明公开了一种5‑氯‑2‑氨基苯甲酸的制备方法,属于有机合成技术领域,具体为将2,5‑二氯甲苯在溶剂中溶解,搅拌下加入氧化剂,加热升温至50~80°C,保温反应3~6H,反应结束后回收有机溶剂,加水趁热过滤,滤液用盐酸调节至ph=2.冷却,结晶,过滤得到2,5‑二氯苯甲酸,2,5‑二氯苯甲酸加入有机溶剂溶解,加入金属催化剂,碱及氨源,加热至70~150oc后保温反应8~15小时,反应结束后减压蒸馏,得到5‑氯‑2‑氨基苯甲酸.本发明设计了一种合成5‑氯‑2‑氨基苯甲酸的新路径,制备方法简单,易于操作,成本低且对环境友好,且在氨化反应过程中加入n,N‑二甲基甘氨酸,可以降低氨化反应的温度,缩短反应时间,提高反应收率.

专利信息

专利号:US-5783577-A
优先权日:1995-09-15
标题 :Synthesis of quinazolinone libraries and derivatives thereof
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:US-4713383-A
优先权日:1984-10-01
标 题:Triazoloquinazoline compounds, and their methods of preparation, pharmaceutical compositions, and uses
发明人：FRANCIS JOHN E; GELOTTE KARL O
权利人:CIBA GEIGY CORP
摘要:[1,2,4]triazolo[1,5-c]quinazoline compounds of the formula wherein R1 is optionally substituted phenyl, pyridyl, furyl thienyl, dihydro or tetrahydro furanyl or thienyl, pyranyl, or 0-ribofuranosyl; R2 is hydrogen or lower alkyl; X is oxygen or NR3, R3 is as defined in the claims, and ring A is unsubstituted or substituted as set forth in the claims. The compounds wherein X is N-R3 are especially useful as adenosine antagonists and for the treatment of asthma. The compounds wherein X is oxygen are useful as benzodiazepine antagonists and as intermediates in the synthesis of the compounds wherein X is N-R3.

专利号:US-5998620-A
优先权日:1997-03-25
标 题 :Synthesis of intermediates useful in preparing tricyclic compounds
发明人：CHEN XING; POIRIER MARC; WONG YEE-SHING; WU GUANG-ZHONG
权利人:SCHERING CORP
摘要:The invention relates to a process for preparing a compound of the formula ##STR1## comprising reacting a bromo-substituted pyridine with an amine of the formula NHR 5 R 6 , reacting the resulting amide with an iodo-halomethyl-substituted compound and cyclizing the resultant product, wherein R, R 1 , R 2 , R 3 and R 4 are as defined in the specification; also claimed are a compound of the formula ##STR2## and a process for preparing it from the corresponding halo-substituted benzoic acid.

专利号:EP-0977739-B1
优先权日:1997-03-25
标题 :Synthesis of intermediates useful in preparing tricyclic compounds
发明人：CHEN XING; POIRIER MARC; WONG YEE-SHING; WU GUANG-ZHONG
权利人:SCHERING CORP
摘要:The invention relates to a process for preparing a compound of formula (I), comprising reacting a bromo-substituted pyridine with an amine of the formula NHR5R6, reacting the resulting amide with an iodo-halomethyl-substituted compound and cyclizing the resultant product, wherein R, R?1, R2, R3 and R4¿ are as defined in the specification; also claimed are a compound of formula (a), and a process for preparing it from the corresponding halo-substituted benzoic acid.

专利号:US-8022217-B2
优先权日:2006-07-31
标 题 :Compounds suitable as modulators of HDL
发明人：THOMBARE PRAVIN S; LOHRAY BRAJ BHUSHAN; LOHRAY VIDYA BHUSHAN; PATL PANKAJ RAMANBHAI
权利人:CADILA HEALTHCARE LTD
摘要:Disclosed herein in the embodiments of the present invention are the compounds suitable as modulators of HDL having general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

专利号:CA-2284646-C
优先权日:1997-03-25
标 题 :Synthesis of intermediates useful in preparing tricyclic compounds