专利号:US-11746364-B2 优先权日:2018-01-17 标题 :Enzymatic synthesis of kavalactones and flavokavains 发明人:PLUSKAL TOMÃ?S; Weng jing-ke 权利人:WHITEHEAD INST BIOMEDICAL RES 摘要:Disclosed are methods, compositions, proteins, nucleic acids, cells, vectors, compounds, reagents, and systems for the preparation of kavalactones, flavokavains, and kavalactone and flavokavain biosynthetic intermediates using enzymes expressed in heterologous host cells, such as microorganisms or plants, or using in vitro enzymatic reactions. This invention also provides for the expression of the enzymes by recombinant cell lines and vectors. Furthermore, the enzymes can be components of constructs such as fusion proteins. The kavalactones produced can be utilized to treat anxiety disorder, insomnia, and other psychological and neurological disorders. The flavokavains produced can be utilized to treat various cancers including colon, bladder, and breast cancers.
专利号:US-7312343-B2 优先权日:2004-06-02 标 题:Synthesis of α-amino-β-alkoxy-carboxylic acid esters 发明人:SCHMID RUDOLF; ZUTTER ULRICH 权利人:HOFFMANN LA ROCHE 摘要:Compounds of formula I n nand a process for the preparation of such compounds are disclosed.
专利号:US-4161609-A 优先权日:1977-09-14 标题:Synthesis of carboxylic acid esters 发明人:CRAMER RICHARD D 权利人:DU PONT 摘要:A method is provided for converting a carboxylic acid amide to a carboxylic acid ester by reacting a vaporized mixture of the amide and an aliphatic alcohol or a phenol in the presence of a suitable catalyst at temperatures of from 100 DEG C. to 400 DEG C. The process is especially useful for the conversion of methacrylamide to methyl methacrylate.
专利号:US-2010197891-A1 优先权日:2006-10-05 标题:Method for peptide synthesis 发明人:GIRAUD MATTHIEU; ALBERICIO FERNANDO; QUATTRINI FRANCESCA; WERBITZKY OLEG; SENN KATJA; WILLINER MICHAELA 权利人:GIRAUD MATTHIEU; ALBERICIO FERNANDO; QUATTRINI FRANCESCA; WERBITZKY OLEG; SENN KATJA; WILLINER MICHAELA 摘要:A new method of anchoring a growing peptide chain during chemical synthesis to a solid-phase support is devised. Novel amino acid derivatives and peptide derivatives, both unbonded and bonded to a solid-phase support, are also provided.
专利号:WO-2013001830-A1 优先权日:2011-06-30 标题 :Nucleoside antibiotic derivative 发明人:ICHIKAWA SATOSHI; MATSUDA AKIRA; OKAMOTO KAZUYA; SAKAGAMI MASAHIRO 权利人:UNIV HOKKAIDO NAT UNIV CORP; SHIONOGI & CO; ICHIKAWA SATOSHI; MATSUDA AKIRA; OKAMOTO KAZUYA; SAKAGAMI MASAHIRO 摘要:The present invention addresses the problem of providing a new compound having antibacterial activity. Disclosed is a compound expressing antibacterial activity, more preferably an antibacterial nucleoside compound expressing antibacterial activity by inhibiting the activity of MraY, particularly a new derivative of Pacidamycin that is an MraY inhibitor. This new derivative of Pacidamycin or a pharmaceutically acceptable salt therof solve the abovementioned problem. By means of the method of the present invention, total synthesis of natural Pacidamycin D and its derivative is achieved.
专利号:US-11739354-B2 优先权日:2018-01-17 标 题 :Enzymatic synthesis of kavalactones and flavokavains
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合成参考文献
参考文献:10.1186/s13071-017-2609-3 摘要:Percoma L, Sow A, Pagabeleguem S, Dicko AH, Serdebéogo O, Ouédraogo M, Rayaissé J, Bouyer J, Belem AMG, Sidibé I. Impact of an integrated control campaign on tsetse populations in Burkina Faso. Parasites & Vectors. 2018 Apr 27;11(1):270. doi: 10.1186/s13071-017-2609-3.