合成目标产物 2,3-Dimethylbenzoic Acid 主要起始原料 O-Xylene And Carbon Dioxide
(文献来源)合成步骤主要原料 O-Xylene 和 Carbon Dioxide
2,3-二甲基苯胺置于盐酸,Sodium Peroxide,硫酸,Sodium Nitrite体系中,用 水 作为反应溶剂,化学反应 1.33H,反应生成 2,3-二甲基苯甲酸 参考文献:Quantitative Structure-Activity Analysis Of Larvicidal 1-(Substituted Benzoyl)-2-Benzoyl-1-Tert-Butylhydrazines Againstchilo Suppressalis 标题:Quantitative Structure-Activity Analysis Of Larvicidal 1-(Substituted Benzoyl)-2-Benzoyl-1-Tert-Butylhydrazines Againstchilo Suppressalis 摘要:Abstractthe Larvicidal Activity Of A Number Of 1‐(Substituted Benzoyl)‐2‐benzoyl-1 ‐ten‐butylhydrazines Against The Rice Stem Borer (Chilo Suppressalis Walk.) Was Measured. Variations In The Activity Were Examined Quantitatively Using Physico‐chemical Substituent And Molecular Parameters And Regression Analysis. The Results Indicated That The Molecular Hydrophobicity And The Electron‐withdrawing Inductive/ Field Effect Of Ontho Substituents Are Favourable To Larvicidal Activity. The Bulkiness Of Substituents At The Meta And Para Positions Was Unfavourable To Activity,Substitution At The Para Position Being More Unfavourable Than That At The Meta Position In Terms Of Van Der Waals' Volume. The 2,3-,2,5‐ And 2,6‐disubstitution Patterns Were Also Unfavourable To Activity. Reductions In Larvicidal Activity Caused By The 2,6‐,‐ 2,3,5‐ And 2,3,4,5‐substitutions Were Greater Than Those Induced By The 2,3‐ And 2,5‐disubstitutions. When The Sum Of Contributions From Favourable Effects Is Greater Than That From Unfavourable Effects,The Larvicidal Activity Is Expected To Be Superior To That Of The Unsubstituted Compound. DOI:10.1002/ps.2780410210
专利号:US-8742028-B2 优先权日:2009-05-06 标 题:Solid support for Fmoc-solid phase synthesis of peptide acids 发明人:SRIVASTAVA KRIPA S; DAVIS MATTHEW R 权利人:SRIVASTAVA KRIPA S; DAVIS MATTHEW R; MALLINCKRODT LLC 摘要:The present invention provides a solid support for Fmoc-solid phase synthesis of peptides. In particular, the solid supports of the invention may be utilized to produce peptide acids.
专利号:EP-1611083-B1 优先权日:2003-03-25 标 题:Synthesis of 2-chloromethyl-6-methylbenzoic acid esters 发明人:MAIER CLAUS-JUERGEN; METZENTHIN TOBIAS; GRAESER JOACHIM; BICKER RICHARD; MANERO JAVIER 权利人:SANOFI AVENTIS DEUTSCHLAND 摘要:The invention relates to a method for producing compounds of formula (I) wherein R represents H, optionally halogen-substituted alkyl, cycloalkyl or aryl, alkyl-aryl or heteroaryl, and at least one CH2 group can be replaced by O in alkyl and cycloalkyl. Said compounds of formula (I) are valuable intermediates in the synthesis of PPAR agonists.
专利号:WO-2023095077-A1 优先权日:2021-11-26 标题 :A process for the treatment of tail gases 发明人:LODHA DHANANJAY MAHENDRA 权利人:SHREE SULPHURICS PVT LTD 摘要:The present disclosure relates to a process for the treatment of tail gases. The process of the present disclosure is simple and environmentally friendly. The process of the present disclosure produces chlorosulfonic acid, which is a value-added reagent used in the synthesis of alkyl sulphates detergents, saccharin and the like. Further, the process of the present disclosure produces sulfuryl chloride, which is an important value added chlorinating agent in the organic synthesis/reactions.
专利号:US-2020190135-A1 优先权日:2016-11-16 标题 :Lasso structures and their synthesis 发明人:BODE JEFFREY; SAITO FUMITO 权利人:CHROMACON AG 摘要:A method for the synthesis of a molecular lasso structure in which a linear moiety is covalently attached to a cyclic moiety and with its free end is partially threaded through the orifice formed by the cyclic moiety, including the following steps: 1) provision of a cyclic and a first linear structural element and establishing conditions in which the first linear structural element is threaded through the orifice of the cyclic moiety; 2) covalently attaching a stopper element to one terminal end of the linear structural element; 3) separating unthreaded from threaded molecular assemblies by chemical or physical separation; and 4) reacting the threaded molecular assemblies with a second linear structural element so that it is covalently attached to the first linear structural element at its end opposite to the end where the stopper is attached, and so that the second linear structural element is covalently attached to the cyclic moiety.
专利号:US-8481519-B2 优先权日:2005-02-05 标题 :Isolation of atraric acid, synthesis of atraric acid derivatives, and use of atraric acid and the derivatives thereof for the treatment of benign prostatic hyperplasia, prostate carcinoma and spinobulbar muscular atrophy 发明人:HOFFMANN HANS-RAINER; MATUSCH RUDOLF; BANIAHMAD ARIA 权利人:HOFFMANN HANS-RAINER; MATUSCH RUDOLF; BANIAHMAD ARIA; LOHMANN THERAPIE SYST LTS 摘要:A method for isolating atraric acid from biological material, atraric acid derivatives, the chemical synthesis thereof, and the use of atraric acid and the derivatives thereof for treating or producing a medicament for treating benign prostate hyperplasia, prostate carcinoma or spinobulbar muscular atrophy is provided. In addition, a basic substance for the development of other agents used for treating benign prostate hyperplasia, prostate carcinoma, or spinobulbar muscular atrophy is provided.
专利号:US-6214987-B1 优先权日:1994-09-02 标 题 :Compositions for enzyme catalyzed template-independent formation of phosphodiester bonds using protected nucleotides 发明人:HIATT ANDREW C; ROSE FLOYD 权利人:HIATT ANDREW C; ROSE FLOYD D 摘要:A method for the stepwise creation of phosphodiester bonds between desired nucleosides resulting in the synthesis of polynucleotides having a predetermined nucleotide sequence by preparing an initiation substrate containing a free and unmodified 3'-hydroxyl group; attaching a mononucleotide selected according to the order of the predetermined nucleotide sequence to the 3'-hydroxyl of the initiating substrate in a solution containing a catalytic amount of an enzyme capable of catalyzing the 5' to 3' phosphodiester linkage of the 5'-phosphate of the mononucleotide to the 3'-hydroxyl of the initiating substrate, wherein the mononucleotide contains a protected 3'-hydroxyl group, whereby the protected mononucleotide is covalently linked to the initiating substrate and further additions are hindered by the 3'-hydroxyl protecting group. Methods in which a mononucleotide immobilized on a solid support is added to a free polynucleotide chain are also disclosed.
[参考文献]: M Slade, Et Al. Metabolic Fate Of 3,4,5- And 2,3,5-Trimethylphenyl Methylcarbamates, The Major Constituents In Landrin Insecticide. J Agric Food Chem. 1970 May-Jun;18(3):467-74. [参考文献]: S-Y Wang, Et Al. Specific Involvement Of Two Amino Acid Residues In Cis-Nerolidol Binding To Odorant-Binding Protein 5 Alinobp5 In The Alfalfa Plant Bug, Adelphocoris Lineolatus (Goeze). Insect Mol Biol. 2013 Apr;22(2):172-82.
合成参考文献
摘要:Zhang, H.; Liu, C.; Lei, A., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 139. 摘要:J. M. Wilson, N. E. Gore, J. E. Sawbridge and F. Cardenas-Cruz, J. Chem. Soc. (B) 1967, 852. 摘要:B. Luning, Acta Chem. Scand. 14, 321 (1960).