CAS: 594-70-7; 2-Methyl-2-Nitropropane

相似化合物

10017-37-5 60469-70-7 6045-08-5

上下游产品

Isobutane 2,2-dimethylpropane tertiary butyl chloride t-butyl bromide tert-butylaminetert-butylamine di-tert-butyl nitroxide N-tert-butyl-N-phenylhydroxylamine N-tert.-Butyl-N-(2,6-dimethoxy-phenyl)-hydroxylamin

三甲基乙酸置于nitronium Tetrafluoborate,Silver Carbonate体系中,用 N,N-二甲基乙酰胺 作为反应溶剂,化学反应 12.0H,以79%的收率获得产物2-甲基-2-硝基丙烷
参考文献:银(i)促进的ipso羧酸由四氟硼酸硝的-Nitration
标题:银(i)促进的ipso羧酸由四氟硼酸硝的-Nitration
摘要:已经描述了使用四氟硼酸硝基鎓和碳酸银在二甲基乙酰胺中将一系列脂族和芳族羧酸区域选择性硝化为它们相应的硝基化合物的新颖而有效的方法.据信这种转化是通过烷基-银或芳基-银中间体进行的,该中间体随后与硝鎓离子反应形成硝基物质.温和的反应条件下,宽范围的官能团的耐受性,并形成仅的本位相比,硝基烷基和硝基芳烃的合成公知的方法时-Nitrated产品是这种方法的关键特征.
DOI:10.1021/acs.Joc.5B02133

专利信息

专利号:US-2022356182-A1
优先权日:2009-03-27
标题 :Inhibitors of hepatitis c virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-9440991-B2
优先权日:2013-12-23
标 题:Synthesis of an antiviral compound
发明人：CAGULADA AMY; CHAN JOHANN; CHAN LINA; COLBY DENISE A; KARKI KAPIL KUMAR; KATO DARRYL; KEATON KATIE ANN; KONDAPALLY SUDHA; LEVINS CHRIS; LITTKE ADAM; MARTINEZ RUBEN; PCION DOMINIKA; REYNOLDS TROY; ROSS BRUCE; SANGI MICHAEL; SCHRIER ADAM J; SENG PAMELA; SIEGEL DUSTIN; SHAPIRO NATHAN; TANG DONALD; TAYLOR JAMES G; TRIPP JONATHAN; WALTMAN ANDREW W; YU LAWRENCE
权利人:GILEAD SCIENCES INC
摘要:The present disclosure provides processes for the preparation of a compound of formula I: n nwhich is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.

专利号:US-9670134-B2
优先权日:2013-03-28
标 题:Synthesis of (2-nitro)alkyl (meth)acrylates via transesterification of (meth)acrylate esters
发明人：SATHIOSATHAM MUHUNTHAN; WILCZYNSKI ROBERT
权利人:ANGUS CHEMICAL
摘要:Provided is a process for making (2-nitro)alkyl (meth)acrylate compounds of formula I: wherein n, R, R 1 , R 2 , R 3 , R 4 , R 6 , R 7 , and n are as defined herein, by a transesterification reaction between a nitroalcohol compound and a (meth)acrylate compound in the presence of a transesterification catalyst and a free radical inhibitor.

专利号:US-9090661-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; MCCAULEY JOHN A; LUDMERER STEVEN W; LIU KUN; VACCA JOSEPH P; WU HAO; HU BIN; SOLL RICHARD; SUN FEI; WANG XINGHAI; YAN MAN; ZHANG CHENGREN; ZHENG MINGWEI; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-10947203-B2
优先权日:2016-03-25
标题 :1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor
发明人：CHEN TAOSHENG; LIN WENWEI; WANG YUEMING
权利人:ST JUDE CHILDRENS RES HOSPITAL; ST JUDE CHILDRENS RSEARCH HOSPITAL
摘要:In an aspect, the invention relates to 1,4,5-substituted 1,2,3-triazole and 1,2,4,5-substituted imidazoles having a structure represented by a formula: n nwhich are modulators the pregnane X receptor (“PXRâ€?); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of modulating an adverse drug reaction in a mammal using the compounds and pharmaceutical compositions; methods of treatment of a disorder of uncontrolled cellular proliferation, such as a cancer, using the compounds and pharmaceutical compositions; methods of modulating pregnane X receptor activity in a mammal using the compounds and pharmaceutical compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-2017210756-A1
优先权日:2013-12-23
标题 :Synthesis of an antiviral compound