CAS: 57465-28-8; 3,3',4,4',5-Pentachloro-1,1'-Biphenyl
该化合物是多氯联苯(PCB)家族的成员,该家族由合成有机化学品组成,以其环境持久性和潜在毒性著称,其特点是其双苯结构,其五氯原子在双苯环上的特定位置被替换. 多氯联苯126因其与二恶英的结构相似,被归类为二恶英类多氯联苯,二恶英在结构上具有很高的毒性和生物体内生物累积的潜力.它表现出内分泌干扰性,并具有各种有害健康影响,包括致癌性. 多氯联苯126通常出现在工业应用中,但由于环境和健康问题,其生产在很多国家受到很大禁止或限制. 它在环境中的持久性使其成为一种重大的污染物,经常在土壤,沉积物和生物群中检测到.监测和补救工作对于减轻其对生态系统和人类健康的影响至关重要.
- 英文名称3,3',4,4',5-Pentachloro-1,1'-Biphenyl
- 中文名称3,3',4,4',5-五氯-1,1'-联苯
- IUPAC名称1,2,3-trichloro-5-(3,4-dichlorophenyl)benzene
- 其它别名3,3',4,4',5-五氯联苯; 3,3',4,4',5-Pentachlorobiphenyl
- CAS编号57465-28-8
- MFCD编号:MFCD00152730
- EINECS号:682-346-8
- FDA UNII编号:TSH69IA9XF
- 分子式:C12H5Cl5分子量:326.43
- 产品CID: 1549684
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: REHONNLQRWTIFF-UHFFFAOYSA-N
- InChI=1S/C12H5Cl5/c13-8-2-1-6(3-9(8)14)7-4-10(15)12(17)11(16)5-7/h1-5H
- 计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS08 & GHS09;
注释: Health hazard & Environment - 危险类别特定目标器官毒性-重复接触 类别2
水生急性毒性 类别1
水生慢性毒性 类别1 - 警示词Warning(警告)
- 危险描述H373 |长期或反复接触可能损害器官.
H400 |对水生生物毒性极大.
H410 |对水生生物毒性极大并具有长期持续影响. - 防范说明P260-P273-P391-P501
- 安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)
- 危险类别码Clear evidence of carcinogenicity in female rats; [NTP] Classified as Group 1 based on animal evidence and mechanistic data (strong evidence for an aryl hydrocarbon receptor) without epidemiological evidence; [IARC 2012] May have cumulative adverse effects; Targets the liver, kidney, CNS, and skin; [Cerilliant MSDS] See Polychlorinated biphenyls and linked occupational disease.
欧盟法规
C&L通报上下游产品
3',4,4',5-tetrachloro-3-nitrobiphenyl 1,2-dichloro-benzene 3,4,5-trichloroaniline 1,2-Dichloro-3-nitrobenzene合成工艺路线路线简述
📜2,3-二氯硝基苯置于四氯化碳,硝酸异戊酯体系中,化学反应 3.5H,反应生成 3,3',4,4',5-五氯联苯
参考文献:Bergman,Ake; Nilsson,Andreas; Riego,Juan,Acta Chemica Scandinavica,1990,Vol. 44,# 10,P. 1071-1076
标题:Bergman,Ake; Nilsson,Andreas; Riego,Juan,Acta Chemica Scandinavica,1990,Vol. 44,# 10,P. 1071-1076
海关参考信息
- 2903911000-邻二氯苯
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1016/j.aquatox.2011.06.011
摘要:Vicquelin L, Leray-Forget J, Peluhet L, LeMenach K, Deflandre B, Anschutz P, Etcheber H, Morin B, Budzinski H, Cachot J. A new spiked sediment assay using embryos of the Japanese medaka specifically designed for a reliable toxicity assessment of hydrophobic chemicals. Aquat Toxicol. 2011 Oct;105(3-4):235–45. doi: 10.1016/j.aquatox.2011.06.011.
参考文献:10.1530/rep.1.00761
摘要:Pocar P, Nestler D, Risch M, Fischer B. Apoptosis in bovine cumulus-oocyte complexes after exposure to polychlorinated biphenyl mixtures during in vitro maturation. Reproduction. 2005 Dec;130(6):857–68. doi: 10.1530/rep.1.00761.
参考文献:10.1093/toxsci/kfr189
摘要:He G, Tsutsumi T, Zhao B, Baston DS, Zhao J, Heath-Pagliuso S, Denison MS. Third-generation Ah receptor-responsive luciferase reporter plasmids: amplification of dioxin-responsive elements dramatically increases CALUX bioassay sensitivity and responsiveness. Toxicol Sci. 2011 Oct;123(2):511–22.
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