CAS: 55399-93-4; (2S,3R,4S)-2-Amino-4-Hydroxy-3-Methylpentanoic Acid

相似化合物

781658-23-9 6667-60-3 55399-92-3

上下游产品

CAS号55527-86-1 (3S,4R,5S)-3-am... | CAS号21704-91-6 (3S,4R,5S)-3-am... | CAS号1093653-23-6 N-((3S,4R,5S)-4... | CAS号600-18-0 2-丁酮酸 | CAS号75-07-0 乙醛

📜4-Hydroxyisoleucine γ-Lactone置于lithium Hydroxide,水,溶剂黄146体系中,用 水 作为反应溶剂,化学反应 2.0H,反应生成 (4S)-4-羟基异亮氨酸
参考文献:Wo2006/117696
标题:Wo2006/117696

专利信息

专利号:US-7326805-B2
优先权日:2003-05-07
标题 :Method for the synthesis of 4-hydroxyisoleucine and the derivatives thereof
发明人：MIOSKOWSKI CHARLES; CATALA CEDRIC; WAGNER ALAIN
权利人:MIOSKOWSKI CHARLES; CATALA CEDRIC; WAGNER ALAIN
摘要:The invention relates to a method for the synthesis of two isomers, at function OH, alone or in mixtures, of amino acids α or the derivatives thereof, having general formula (B), wherein: linkage C—O of the 4-position carbon (represented by symbol) denotes one or other of isomers III or IV, or mixtures thereof. Moreover, R 1 and R 2 represent: a hydrogen atom; or either R 1 or R 2 represents a hydrogen atom and the other substituent is a radical R a , an acyl group —COR a , such as acetyl, or a functional group —COOR a , —SO 2 R a , —N (R a , R b ), R a and R b , which are identical or different, representing a C1-C12 linear or branched alkyl radical, optionally substituted, an aryl group with one or more aromatic rings and heterocycles, comprising between 5 and 8C, optionally substituted, or aralkyl, the alkyl substituent and the aryl group being as defined above; or R 1 and R 2 both represent a substituent as defined above. R 3 represents a hydrogen atom or R a and R 4 has the significance of R a . The invention is characterised in that it comprises: the isomerisation of a compound having formula (I), wherein R 1 , R 2 , R a , R 3 and R 4 are as defined above, such as to produce a compound having formula (II); and the reduction of the carbonyl function thereof which, depending on the catalytic system employed and the formula (I) compound used, produces one of the isomers having general formula (III) or (IV) or a mixture thereof having formula (B). The invention can be used for the synthesis of (2S, 3R, 4S)-4-hydroxyisoleucine.

专利号:WO-2025077487-A1
优先权日:2023-10-12
标 题 :ENZYME SELF-ASSEMBLY COMPLEX FOR SUPPLYING α-KETOGLUTARATE AND USE THEREOF IN CATALYTIC SYNTHESIS OF 4-HYDROXYISOLEUCINE
发明人：NIE YAO; XU YAN; LIU HUAN
权利人:UNIV JIANGNAN
摘要:An enzyme self-assembly complex for supplying α-ketoglutarate and the use thereof in catalytic synthesis of 4-hydroxyisoleucine, which belong to the technical field of biocatalysis. Glutamate oxidase catalyzes the production of α-KG from glutamate, and catalase decomposes the by-product H 2 0 2 , the RIAD-RIDD interaction and merged state resulting from covalent ligation can mediate the characteristics of a higher-order structure of a plurality of self-assembly enzymes, and an LGOX/KatG self-assembly system is constructed in vitro through the affinity of short peptides, enabling the in situ elimination of H 2 O 2 and relieving the inhibition of H 2 O 2 on Fe(II)/α-KG DOs. The system is cascaded with IDO to achieve efficient and high-yield production of 4-HIL in a one-pot system, with a maximum yield of 95% at the substrate concentration of 100 mM.

专利号:WO-2008154743-A1
优先权日:2007-06-19
标题 :Methods for the synthesis of 4-hydroxyisoleucine, stereoisomers and analogs thereof
发明人：LAIRD TREVOR; PHAM ANH THU; SPINDLER FELIX; SCHUMACHER ANDREAS; SACHLEBEN RICHARD A
权利人:INNODIA INC; LAIRD TREVOR; PHAM ANH THU; SPINDLER FELIX; SCHUMACHER ANDREAS; SACHLEBEN RICHARD A
摘要:A method for synthesizing 4-hydroxyisoleucine, stereoisomers and analogs thereof having a general formula I is disclosed herein. The method comprises reacting an alkyl isocyanoacetate of formula III with an acetoin or an acetoin analog of formula II to give an unsaturated N-formyl lactone of formula IV, hydrogenating the unsaturated N-formyl lactone to give N-formyl lactone of formula V and hydrolysing said lactone to yield the desired product of formula I.

专利号:US-7670822-B2
优先权日:2006-03-24
标题 :Aldolase and production process of 4-hydroxy-L-isoleucine
发明人：SMIRNOV SERGEY VASILIEVICH; SAMSONOVA NATALIA NIKOLAEVNA; KODERA TOMOHIRO; MATSUI KAZUHIKO
权利人:AJINOMOTO KK
摘要:A novel aldolase is described. 4-hydroxy-3-methyl-2-keto-pentanoic acid, which is useful as an intermediate in the synthesis of 4-hydroxy-L-isoleucine, may be synthesized from acetaldehyde and α-ketobutyric acid using a novel aldolase, which is derived from the genus Arthrobacter.

专利号:US-2005176827-A1
优先权日:2002-05-10
标 题:Compositions and methods for glycogen synthesis
发明人：LEE STEVE S; HYNSON RICHARD B; RUBY BRENT C; GASKILL STEVEN E
摘要:A composition of bio-active compounds and methods for facilitating and supporting the metabolism and transport of glucose and carbohydrates into muscle cells, promoting muscle function and growth, promoting glycogen synthesis, enhancing glucose disposal, stimulating pancreatic beta cells, promoting metabolic recovery, promoting muscle recovery, promoting lean body mass, and promoting fat burning. Preferably, the composition of bio-active compounds includes a combination of 4-hydroxyisoleucine with at least one amino acid selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, lysine, histidine, gamma-amino butyrate and tyrosine. In one presently preferred embodiment of the present invention, the combination is derived, isolated, and/or extracted from fenugreek seeds. Methods for using a novel composition of bio-active compounds from fenugreek seed for facilitating and supporting the metabolism and transport of glucose and carbohydrates into muscle cells, promoting muscle function and growth, promoting glycogen synthesis, enhancing glucose disposal, stimulating pancreatic beta cells, promoting metabolic recovery, promoting muscle recovery, promoting lean body mass, and promoting fat burning are also disclosed, wherein methods comprise the steps of: (1) providing an effective amount of a composition of bio-active compounds derived, isolated, and/or extracted from fenugreek seeds; and (2) administering the composition to a human or animal.

专利号:US-10723766-B2
优先权日:2015-11-27
标题 :Derivatives of gamma-amanitin
发明人：WERNER-SIMON SUSANNE; LUTZ CHRISTIAN; MüLLER CHRISTOPH; SIMON WERNER
权利人:HEIDELBERG PHARMA RES GMBH
摘要:The invention relates to γ-amaninamide (1; x=0, 1 or 2), γ-amaninamidic acid (2; x=0, 1 or 2), and γ-amaninamidic hydroxamic acid (3; x=0, 1 or 2), novel derivatives of γ-amanitin (4), and methods and novel building blocks for the synthesis thereof.