CAS: 53064-79-2; Iodomethyl Pivalate

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CAS号18997-19-8 特戊酸氯甲酯 | CAS号66542-51-6 chloromethyl he... | CAS号3282-30-2 特戊酰氯 | CAS号65243-33-6 头孢他美酯 | CAS号105889-45-0 头孢卡品酯 | CAS号70-55-3 对甲苯磺酰胺 | CAS号142340-99-6 阿德福韦酯 | CAS号117467-28-4 头孢妥仑匹酯 | CAS号123290-35-7 (3-ox°Cyclohexe... | CAS号117941-44-3 [(Z)-[1-(2,2-di... | CAS号2522-81-8 匹贝卡

特戊酸氯甲酯置于sodium Iodide体系中,用 乙腈 作为反应溶剂,化学反应生成 特戊酸碘甲酯
参考文献:2'-C-甲基核糖核苷的3',5'-环磷酸酯和硫代磷酸酯的合成
标题:2'-C-甲基核糖核苷的3',5'-环磷酸酯和硫代磷酸酯的合成
摘要:已知2'-C-甲基核苷具有抗丙型肝炎病毒的抗病毒活性.由于抑制活性取决于它们在细胞内转化为5'-三磷酸的能力,因此以适当保护的5'-磷酸或5'-硫代磷酸酯的剂量给药似乎很有吸引力.为了这个目的,2'-四潜在前药ç-Methylguanosine,即,2'-的5'-环硫代磷酸酯,3' ç-Methylguanosine和2'-ç,ò 6-Dimethylguanosine,1和2分别中,小号-[(新戊酰氧基)甲基] 2'酯ç,ò 6-Dimethylguanosine 3',5'-环硫代磷酸酯和ó的甲基酯2'-ç,ö 6-Dimethylguanosine 3',5'-环磷酸,3和4,分别为已被制备.
DOI:10.1002/hlca.201200099

专利信息

专利号:US-10047122-B2
优先权日:2013-03-14
标 题 :Peptide and peptide mimetic binding antagonists of polo-like kinase 1 polo box domain and methods of use
发明人：QIAN WENJIAN; PARK JUNG EUN; LAI CHRISTOPHER C; KELLEY JAMES A; LEE KYUNG S; BURKE JR TERRENCE R
权利人:THE US SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
摘要:The invention provides novel compounds that may serve as anticancer therapeutics. The compounds of the invention bind to polo-like kinases through the polo-box domain. In certain embodiments, the compounds of the invention are POM-protected peptide derivatives. The use of cationic bis-alkyl his residues in combination with a mono POM-protected phophoryl group results in a peptide possessing an overall neutral charge. The peptide derivatives of the invention have achieved both good efficacy and an enhanced bioavailability. The invention also provides methods of use, compositions, and kits thereof. Further, the invention provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents.

专利号:US-8536318-B2
优先权日:2008-05-29
标题 :Chemical RNA synthesis method
发明人：DEBART FRANCOISE; VASSEUR JEAN-JACQUES; LAVERGNE THOMAS
权利人:DEBART FRANCOISE; VASSEUR JEAN-JACQUES; LAVERGNE THOMAS; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER 2
摘要:The invention relates to a method for the chemical synthesis of RNA, comprising the following steps: a) bonding to a solid support of a monomer having formula (II) in which—X 1 is a dimethoxytrityl group,—X 6 is H or an OAc group or OX 3 , in which X 3 is a group having formula (A), in which X is O or S, R′ is H or CH 3 and R is selected from a linear or branched alkyl group at C 1 to C 4 and a R 1 —O—R 2 group in which R 1 is an alkyl group at C 1 to C 2 and R 2 is a CH 3 group or CH 2 CH 2 —O—CH 3 or aryl; b) assembly with the monomer having formula (II) bound to the support thereof obtained in step (a) of at least one monomer having formula (III) in which X 1 , Bp, X 3 are as defined for formula (II) and X 5 is a hydrogen phosphonate monoester or phosphoramidite group, preferably a 2-cyanoethyl-N,N-diisopropylphosphoramidite group, which is used to obtain a protected single-strand RNA bound to a support.

专利号:US-9963472-B2
优先权日:2013-11-04
标 题 :Stable pantetheine derivatives for the treatment of pantothenate kinase associated neurodegeneration (PKAN) and methods for the synthesis of such compounds
发明人：JENKO BRANKO; KOSEC GREGOR; PETKOVIC HRVOJE; PODGORSEK BERKE AJDA; PAHOR JERCA; CUSAK ALEN; SIBON ODA CORNELIA MARIA; SRINIVASAN BALAJI
权利人:ACIES BIO D O O; UNIV GRONINGEN; ACADEMISCH ZIEKENHUIS GRONINGEN
摘要:The invention relates to (S)-acyl-4′-phosphopantetheine derivatives, methods of their synthesis, and related medical uses of such compounds. Preferred medical uses relate to the treatment of neurodegenerative diseases, such as PKAN.

专利号:US-9907796-B2
优先权日:2012-10-04
标题:Methods of treating tumoral diseases, or bacterial or viral infections
发明人：DEOKAR RHUSHIKESH CHANDRABHAN; DUGAR SUNDEEP; MAHAJAN DINESH; WERNER MILTON HENRY
权利人:DEOKAR RHUSHIKESH CHANDRABHAN; DUGAR SUNDEEP; MAHAJAN DINESH; WERNER MILTON HENRY; INHIBIKASE THERAPEUTICS INC
摘要:Novel compounds and their synthesis are described. Methods for using these compounds in the prevention or treatment of cancer, a bacterial infection or a viral infection in a subject are also described.

专利号:US-2018118767-A1
优先权日:2013-11-04
标题 :Stable pantetheine derivatives for the treatment of pantothenate kinase associated neurodegeneration (pkan) and methods for the synthesis of such compounds

专利号:EP-3066106-A1
优先权日:2013-11-04
标题 :Stable pantetheine derivatives for the treatment of pantothenate kinase associated neurodegeneration (pkan) and methods for the synthesis of such compounds