CAS: 495-78-3; 3-(2-Hydroxyphenyl)Propanoic Acid

该化合物是一种含有C9H10O3分子配方的酚类衍生物,其分子式为C9H10O3, 其成分为碳酸和芳香环上的氢氧化物组.该化合物在有机合成中广泛用作中间体,特别是在生产药品,农用化学品和特殊化学品方面.其结构特性使得多功能反应,包括酯化,恐吓和电益替代,使其对设计生物活性分子很有价值.氢氧基组增加了极溶剂的溶性,而芳香环则有助于稳定性.该化合物还被研究由于苯基混合物而具有的潜在抗氧化性.它可用于研究和工业应用的高纯度,确保合成途径的一贯性.

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CAS号91-64-5 香豆素 | CAS号614-60-8 2-羟基肉桂酸; 邻羟基肉桂酸 | CAS号20349-89-7 甲基3-(2-羟基苯基)丙酸甲酯 | CAS号86571-26-8 1,1,1-trifluoro... | CAS号645-45-4 3-苯丙酰氯 | CAS号501-52-0 3-苯丙酸 | CAS号1643-28-3 3-(2-氯苯基)丙酸 | CAS号288311-17-1 2-trifluorometh... | CAS号95-13-6 茚 | CAS号40492-92-0 2-苯氧基苯丙酸 | CAS号90-00-6 2-乙基苯酚 | CAS号20921-00-0 6-溴苯并吡喃-2-酮 | CAS号22367-76-6 3-(2-羟基苯基)丙酰胺 | CAS号20921-04-4 3-(2-羟基苯基)丙酸乙酯 | CAS号2669-94-5 2H-1-Benzopyran... | CAS号24535-13-5 3-(2-羟基苯基)丙酰肼 | CAS号19063-55-9 6-溴-2H-苯并吡喃-2-酮 | CAS号20349-89-7 甲基3-(2-羟基苯基)丙酸甲酯 | CAS号220285-28-9 3-(2-乙氧基苯基)丙酸

合成工艺路线路线简述

    氢化肉桂酸内酯置于octadecyltriethoxysilane-Treated High-Silica Hβ-20 Zeolite体系中,用 水 作为反应溶剂,化学反应 24.0H,以75%的收率获得产物3-(2-羟基苯基)丙酸
    参考文献:高二氧化硅大孔沸石在水中/水中催化水解疏水酯
    标题:高二氧化硅大孔沸石在水中/水中催化水解疏水酯
    摘要:水不溶性酯的水解是工业上重要但具有挑战性的反应,因为在反应过程中酯主要存在于水的油滴中.根据25种非均相和均相催化剂在水上/水中水解水不溶性酯3-苯基丙酸酯的筛选结果,我们发现具有中等si / Al比(si / Al = 75)hβ-75,是一种有效且可重复使用的水解疏水酯的催化剂.用具有不同si / Al比的hβ和hzsm5沸石研究了不同尺寸酯的水解,结果表明疏水性,孔径和布朗斯台德酸位点数量是影响该系统催化活性的关键因素.
    DOI:10.1016/j.Jcat.2016.08.021

    海关参考信息

    专利信息


    专利号:US-5350864-A
    优先权日:1990-05-03
    标 题:Aminoalkylcarbamyl derivatives of forskolin as intermediates for the synthesis of useful forskolin derivatives
    发明人:SEAMON KENNETH B; ROBBINS JOAN; LAURENZA ANTONIO
    权利人:US HEALTH
    摘要:The subject matter of the present invention relates to aminoalkylcarbamates of forskolin and the methods of using these compounds. Specifically, the aminoalkylcarbamates may be utilized in the synthesis of forskolin derivatives. The final derivatives may, in turn, be used in the development of in vivo and in vitro assays designed to study different proteins.

    专利号:US-6180830-B1
    优先权日:1995-11-08
    标题 :Method for preparing a bimetallic ruthenium/tin catalyst and a process for the synthesis of aldehydes
    发明人:JACQUOT ROLAND
    权利人:RHODIA CHIMIE SA
    摘要:The present invention relates to a new process for the preparation of a bimetallic ruthenium/tin catalyst. The process for the preparation of a bimetallic ruthenium/tin catalyst according to the invention is characterised by the fact that it consists in carrying out the reduction of a ruthenium complex having an electrovalency of -4 and a coordination number of 6, the ligands being either a halogen atom or an anion or a tin halide. The catalyst is further employed for the preparation of aldehydes by reduction, in the vapor phase, of carboxylic acids, esters and anhydrides.

    专利号:US-11746364-B2
    优先权日:2018-01-17
    标题 :Enzymatic synthesis of kavalactones and flavokavains
    发明人:PLUSKAL TOMÃ?S; Weng jing-ke
    权利人:WHITEHEAD INST BIOMEDICAL RES
    摘要:Disclosed are methods, compositions, proteins, nucleic acids, cells, vectors, compounds, reagents, and systems for the preparation of kavalactones, flavokavains, and kavalactone and flavokavain biosynthetic intermediates using enzymes expressed in heterologous host cells, such as microorganisms or plants, or using in vitro enzymatic reactions. This invention also provides for the expression of the enzymes by recombinant cell lines and vectors. Furthermore, the enzymes can be components of constructs such as fusion proteins. The kavalactones produced can be utilized to treat anxiety disorder, insomnia, and other psychological and neurological disorders. The flavokavains produced can be utilized to treat various cancers including colon, bladder, and breast cancers.

    专利号:US-9453037-B2
    优先权日:2011-07-28
    标 题 :Methylphenidate-prodrugs, processes of making and using the same
    发明人:GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
    权利人:KEMPHARM INC; KEMPHARM INC
    摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

    专利号:US-9102961-B2
    优先权日:2009-03-11
    标 题 :Biological synthesis of difunctional hexanes and pentanes from carbohydrate feedstocks
    发明人:BAYNES BRIAN M; GEREMIA JOHN MICHAEL; LIPPOW SHAUN M
    权利人:CELEXION LLC
    摘要:Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms. The invention also provides recombinant microorganisms and metabolic pathways for the production of difunctional alkanes.

    专利号:US-6531470-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
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    合成参考文献


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    参考文献:10.1016/s0021-9258(19)61721-7|10.1016/s0021-9258(19)63273-4
    摘要:KOUKOL J, CONN EE. The metabolism of aromatic compounds in higher plants. IV. Purification and properties of the phenylalanine deaminase of Hordeum vulgare. J Biol Chem. 1961 Oct;236():2692–8.
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