CAS: 430-51-3; 1-Fluoropropan-2-One

该化合物是一种无色,挥发性液体,有独特的气味,被归类为卤化酮;其化学配方为C3H5FO,其特点是与乙酰集团相连的氟原子,有助于其独特的反应和特性;氟丙酮在有机合成中的潜在用途和作为各种氟化化合物生产的中间体,众所周知,氟丙酮在水中具有中等溶解性,在有机溶剂中更易溶解;氟原子的存在增强了其电子动力,使其在核生殖替代反应中成为有用的再剂;然而,氟丙酮因其毒性和潜在健康危害而得到承认,需要谨慎处理,并在实验室环境中采取适当的安全措施;氟丙酮的活性和存在可导致形成各种衍生物,扩大其在化学研究和工业应用中的用途.

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431-05-0 86455-17-6

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上下游产品

diazomethane acetyl fluoride diazoacetone 1-fluoropropan-2-ol3-fluoro-2,4-pentanedione 1-fluoropropan-2-ol 1-Chloro-3-fluoro-prop-2-one 1-Brom-1-fluor-aceton

合成工艺路线路线简述

    📜溴丙酮置于triethylamine Tris(Hydrogen Fluoride)体系中,110.0~115.0 °C,27.0 Kpa 条件下,以90%的收率获得产物氟代丙酮
    参考文献:超级三氟化氢叔胺和荧光素
    标题:超级三氟化氢叔胺和荧光素
    摘要:叔胺三氢氟化物是可蒸馏的稳定络合物,可以无危险地处理且不会腐蚀硼硅酸盐玻璃.因此,它们在氯或溴原子的亲核取代反应中通过形成氟的均相反应混合物是方便的试剂,通常在非常温和的条件下导致较高的收率.给出了用于制备氟丙酮,氰尿酰氟,二氟光气,草酰氟和四氟化硫的实例.
    DOI:10.1016/s0022-1139(00)81775-3

    海关参考信息

    专利信息


    专利号:US-2025197202-A1
    优先权日:2023-12-15
    标题 :Synthesis of new polymers for the manufacture of solid hydrogen transfer agents
    发明人:GÓMEZ EMILIO LEAL; MANCERA LEÓN PABLO TORRES; JUÃ?REZ JORGE ANCHEYTA; MARTÃ?NEZ FERNANDO ALONSO; VÃ?ZQUEZ LAURA OLIVIA ALEMÃ?N
    权利人:MEXICANO INST PETROL
    摘要:This disclosure refers to a method for the synthesis of polymers with weight average molecular weights greater than 50,000 g/mol, chemically inert, with a minimum decomposition temperature of 425° C., and a main chain composed only of carbon-carbon bonds, which contain structures of the type of naphthalene, phenanthrene, anthracene, pyrene, carbazole or any other where two or more aromatic rings of six carbon atoms of the benzene-type are fused, which may or may not contain aromatic heterocycles. In addition, the polymers obtained from the present disclosure may or may not contain fluorine atoms in their structure. The synthesis described here is carried out by means of polycondensation between a polycyclic aromatic compound and a compound with a carbonyl group in its structure in a strong acid medium.

    专利号:US-12247037-B2
    优先权日:2018-12-12
    标题:1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4h-benzo[f][1,2,4]triazolo[4,3-A][1,4]diazepine derivatives and related compounds as vasopressin antagonists for the treatment of neuro-psychological disorders
    发明人:BRANDT GARY
    权利人:NEUMORA THERAPEUTICS INC
    摘要:The present invention relates to 1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine derivatives and related compounds of Formula (I): wherein A, B, G, R1, R1b, RiC, R2 and X are as defined herein. The present compounds are vasopressin receptor antagonists (in particular of the Via receptor) for the treatment of neuro-psychological disorders, such as e.g. autism, anxiety, stress-related disorders, depression, schizophrenia or bipolar disorder. The present description discloses the synthesis of exemplary compounds, as well as pharmacological data thereof (e.g. pages 71 to 246; examples 1 to 49; tables 1 to 5). An exemplary compound is e.g. 8-chloro-1-(2-(5-fluoropyridin-2-yl)-2,6-diazaspiro[3.3]heptan-6-yl)-5-methyl-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine (example 1, compound no. 1).

    专利号:EP-0042408-A1
    优先权日:1979-12-26
    标 题 :METHODS OF SYNTHESIS OF HEXAFLUOROISOPROPANOL FROM IMPURE MIXTURES AND SYNTHESIS OF A FLUOROMETHYL ETHER.

    专利号:WO-8101843-A1
    优先权日:1979-12-26
    标 题 :Methods of synthesizing hexafluoroisopropanol from impure mixtures and synthesis of a fluoromethyl ether therefrom

    专利号:US-8653223-B2
    优先权日:2008-04-16
    标题:Transketalized compositions, synthesis, and applications
    发明人:SELIFONOV SERGEY; GOETZ ADAM EDWARD; JING FENG
    权利人:SELIFONOV SERGEY; GOETZ ADAM EDWARD; JING FENG; SEGETIS INC
    摘要:Ketal compounds of the structure I n nand a method of preparation of the compound from polyols and oxocarboxylates, as well as uses thereof.

    专利号:US-2012059163-A1
    优先权日:2005-04-28
    标题 :Non-linear opticaly active molecules, their synthesis, and use
    发明人:MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B
    权利人:MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN B; OPTIMER PHOTONICS INC
    摘要:In one aspect, the present invention provides a hyperpolarizable organic chromophore. The chromophore is a nonlinear optically active compound that includes a Ï€-donor conjugated to a Ï€-acceptor through a Ï€-electron conjugated bridge. In other aspects of the invention, donor structures and acceptor structures are provided. In another aspect of the invention, a chromophore-containing polymer is provided. In one embodiment, the chromophore is physically incorporated into the polymer to provide a composite. In another embodiment, the chromophore is covalently bonded to the polymer, either as a side chain polymer or through crosslinking into the polymer. In other aspects, the present invention also provides a method for making the chromophore, a method for making the chromophore-containing polymer, and methods for using the chromophore and chromophore-containing polymer.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Laura B Favero, Et Al. How Trifluoroacetone Interacts With Water. J Phys Chem A. 2011 Sep 1;115(34):9493-7.
    [参考文献]: Telma R Doi, Et Al. 13C Nmr, Infrared, Solvation And Theoretical Investigation Of The Conformational Isomerism In 1-Haloacetones (X = Cl, Br And I). Spectrochim Acta A Mol Biomol Spectrosc. 2005 Jul;61(9):2221-30.
    [参考文献]: Xiao-Hua Chen, Et Al. Organocatalyzed Highly Enantioselective Direct Aldol Reactions Of Aldehydes With Hydroxyacetone And Fluoroacetone In Aqueous Media: The Use Of Water To Control Regioselectivity. Chemistry. 2007;13(2):689-701.

    合成参考文献


    摘要:Shibatomi, K., Science of Synthesis Knowledge Updates, (2017) 2, 399.
    摘要:Benohoud, M.; Hayashi, Y., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 97.
    摘要:Clapés, P.; Fessner, W.-D., Science of Synthesis: Stereoselective Synthesis, (2011) 2, 727.
    摘要:Clapés, P., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 2, 79.
    摘要:Clapés, P., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 2, 82.
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