CAS: 351003-36-6; 2-Fluoro-5-Iodobenzonitrile

上下游产品

3-cyano-4-fluorophenylboronic acid N-[3-(3-cyano-4-fluorophenyl)prop-2-yn-1-yl]-N-(2,4-dimethoxybenzyl)-1H-pyrrole-2-carboxamide

3-氰基-4-氟苯硼酸置于n-碘代丁二酰亚胺,Potassium Acetate体系中,用 乙腈 用作溶剂,化学反应 4.0H,以59%的收率获得2-氟-5-碘苯甲腈
参考文献:使用亲电子卤素的铜催化的芳基硼酸卤代硼化的机理:放射性标记应用的碱催化的碘脱硼化的发展.
标题:使用亲电子卤素的铜催化的芳基硼酸卤代硼化的机理:放射性标记应用的碱催化的碘脱硼化的发展.
摘要:报道了使用亲电子卤素试剂对铜催化的芳基硼酸卤代硼烷化反应机理的研究.提供的证据表明这是通过硼酸酯驱动的ipso取代途径发生的,并且这些过程的运行不需要cu:一般的lewis碱催化是可行的.这进而允许合理开发通用,简单且有效的碱催化卤代硼烷,该卤代硼烷适合制备125 I标记的spect应用产品.
Doi:10.1021/acs.Orglett.9B00942

专利信息

专利号:US-8507538-B2
优先权日:2009-11-13
标 题:Selective heterocyclic sphingosine 1 phosphate receptor modulators
发明人：BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD
权利人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD; RECEPTOS INC
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

专利号:US-9481659-B2
优先权日:2011-05-13
标 题 :Selective heterocyclic sphingosine 1 phosphate receptor modulators
发明人：BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD
权利人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM RICHARD; CELGENE INT II SÀRL
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds is provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

专利号:WO-2006081562-A2
优先权日:2005-01-28
标题:Synthesis of aryl pyrrolidones

专利号:US-8344010-B2
优先权日:2008-12-26
标 题 :Fused imidazole derivatives as TRPV3 antagonist
发明人：LINGAM V S PRASADARAO; THOMAS ABRAHAM; PHATANGARE SHANTARAM KASHINATH; MINDHE AJIT SHANKAR; KHATIK JAVED YUSUF; KHAIRATKAR-JOSHI NEELIMA; KATTIGE VIDYA GANAPATI
权利人:GLENMARK PHARMACEUTICALS SA; LINGAM V S PRASADARAO; THOMAS ABRAHAM; PHATANGARE SHANTARAM KASHINATH; MINDHE AJIT SHANKAR; KHATIK JAVED YUSUF; KHAIRATKAR-JOSHI NEELIMA; KATTIGE VIDYA GANAPATI
摘要:The present invention provides transient receptor potential vanilloid (TRPV) modulators of formula (I). In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPV3. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPV3.