CAS: 34723-82-5; 2-(Bromomethyl)Tetrahydro-2H-Pyran

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专利信息

专利号:US-2023357286-A1
优先权日:2020-07-24
标 题:Ketone synthesis and applications
发明人：KISHI YOSHITO; UMEHARA ATSUSHI
权利人:HARVARD COLLEGE
摘要:Provided are new nickel./zirconium-mediated coupling reactions useful in the synthesis of ketone-containing compounds, e.g., halichondrin natural products and related molecules. A feature of the present disclosure is the use of a nickel(I) catalyst in tandem with a nickel (II) catalyst in the Ni/Zr-mediated coupling reactions. Without wishing to be bound by any particular theory, the nickel (I) catalyst selectively activates the electrophilic coupling partner (i.e., the compound of Formula (A)), and the nickel(ll) catalyst selectively activates the nucleophilic coupling partner (i.e., a thioester of Formula (B)). This dual catalyst system leads to improved coupling efficiency and eliminates the need for a large excess of one of the coupling partners (i.e., a compound of Formula (A) or (B)).

专利号:US-6642390-B2
优先权日:2001-07-11
标 题:One step synthesis of 1,2,3-triazole carboxylic acids
发明人：KOLB HARTMUTH C; CAVALLARO CULLEN; SHI ZHI-CAI; GONTCHAROV ALEXANDER; WANG ZHI-MIN; RICHARDSON PAUL F; KANAMARLAPUDI RAMANAIAH C
权利人:LEXICON PHARMACEUTICALS INC
摘要:Disclosed is a one step method for preparing a 1,2,3-triazole carboxylic acid by treating an azide with a beta-ketoester in the presence of a base.

专利号:US-2003135050-A1
优先权日:2001-07-11
标题 :One step synthesis of 1,2,3-triazole carboxylic acids

专利号:US-2012295923-A1
优先权日:2010-01-29
标 题:Aminocyclohexanes and Aminotetrahydropyrans and Related Compounds As Gamma-Secretase Modulators
发明人：AM ENDE CHRISTOPHER WILLIAM; FISH BENJAMIN ADAM; JOHNSON DOUGLAS SCOTT; LIRA RICARDO; O'DONNELL CHRISTOPHER JOHN; PETTERSSON MARTIN YOUNGJIN; STIFF COREY MICHAEL
权利人:AM ENDE CHRISTOPHER WILLIAM; FISH BENJAMIN ADAM; JOHNSON DOUGLAS SCOTT; LIRA RICARDO; O'DONNELL CHRISTOPHER JOHN; PETTERSSON MARTIN YOUNGJIN; STIFF COREY MICHAEL; PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:WO-2022012456-A1
优先权日:2020-07-17
标题:Novel heterocyclic compounds as bet inhibitors
发明人：FANG HAIQUAN; LUO XINFENG; SHU TIANBO; ZHANG JIBING; WU XIANQIANG; ZHU HUI; WANG YING
权利人:CHENGDU EASTON BIOPHARMACEUTICALS CO LTD
摘要:Provided are heterocyclic compounds of formula (I) as bromodomain and extraterminal (BET) inhibitors, pharmaceutical compositions comprising the compounds, their synthesis and their use for treating diseases and conditions wherein inhibition of one or more BET bromodomains provides a benefit.

专利号:US-6613942-B1
优先权日:1997-07-01
标题 :Glucagon antagonists/inverse agonists
发明人：LING ANTHONY; GREGOR VLAD; GONZALEZ JAVIER; HONG YUFENG; KIEL DAN; KUKI ATSUO; SHI SHENGHUA; NAERUM LARS; MADSEN PETER; SAMS CHRISTIAN; LAU JESPER; PLEWE MICHAEL BRUNO; FENG JUN; TENG MIN; JOHNSON MICHAEL DAVID; TESTON KIMBERLY ANN; SIDELMANN ULLA GROVE; KNUDSEN LOTTE BJERRE
权利人:NOVO NORDISK AS
摘要:Non-peptide compounds comprising a central hydrazide motif and methods for the synthesis thereof are disclosed. The compounds act to antagonize the action of the glucagon peptide hormone.