1-(4-Methoxybenzoyl)-Imidazole置于一水合肼体系中,用 四氢呋喃 用作溶剂,化学反应生成对甲氧基苯甲酰肼 参考文献:Sar Studies On 1,2,4-Triazolo[3,4-B][1,3,4]Thiadiazoles As Inhibitors Of Mtb Shikimate Dehydrogenase For The Development Of Novel Antitubercular Agents 标题:Sar Studies On 1,2,4-Triazolo[3,4-B][1,3,4]Thiadiazoles As Inhibitors Of Mtb Shikimate Dehydrogenase For The Development Of Novel Antitubercular Agents 摘要:三唑噻二唑是一种具有较强抗结核活性的药物,对mtsd有适度的抑制作用,并且没有明显的细胞毒性. Doi:10.1039/c5Ra19334F
专利号:US-2021323987-A1 优先权日:2018-08-20 标题:Methods for the Synthesis of Heteroatom Containing Polycyclic Aromatic Hydrocarbons 发明人:GARG NEIL K; DARZI EVAN R; BARBER JOYANN S; SUSICK ROBERT; CHARI JASON; SPENCE KATIE 权利人:UNIV CALIFORNIA 摘要:Methods for the synthesis of polycyclic aromatic hydrocarbons and synthesis platforms for performing such syntheses are provided. Methods and platforms are provided that allow for the synthesis of aza-polycyclic aromatic hydrocarbons by an expedient ring assembly. Methods and platforms allow for a modular approach to synthesis that provide multiple new C—C bonds in sequential pericyclic reactions, thus giving access to compounds with multiple axes of substitution.
专利号:US-9085550-B2 优先权日:2005-01-21 标题 :Ligands for estrogen related receptors and methods for synthesis of said ligands 发明人:FORMAN BARRY; YU DONNA 权利人:FORMAN BARRY; YU DONNA; HOPE CITY 摘要:Estrogen-Related Receptor (ERR) modulating compounds and methods for synthesis of said compounds are described.
专利号:US-2006189825-A1 优先权日:2005-01-21 标题:Ligands for estrogen related receptors and methods for synthesis of said ligands
专利号:WO-2014051445-A1 优先权日:2012-09-26 标 题:Pyrrole-3,4-dicarboxamides 发明人:PACIOREK PATRYCJA; SZKLARZEWICZ JANUSZ 权利人:UNIV JAGIELLOŃSKI 摘要:The invention relates to the pyrrole derivatives with the general formula in which R 1 is alkyl group C 1 - C 10 , straight or branched, R 2 is -H, -C1, -OH, -NH 2 or -OCH 3 . The invention includes also the method of the synthesis of pyrrole derivatives in the reaction of ketoanilide with hydrazide, with the use of vanadium compound as a reaction promoter.
专利号:US-6291504-B1 优先权日:1999-10-20 标题:Acylsemicarbazides and their uses 发明人:NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; VIDWANS ANUP P; YUE EDDY W 权利人:DU PONT PHARM CO 摘要:The present invention relates to the synthesis of a new lass of indeno[1,2-c]pyrazol-4-ones of formula (I):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
专利号:US-2013131340-A1 优先权日:2005-01-21 标题 :Ligands for estrogen related receptors and methods for synthesis of said ligands
[参考文献]: Cheuk-Fai Chow, Et Al. Metallodynamers: Neutral Double-Dynamic Metallosupramolecular Polymers. Chem Asian J. 2008 Sep 1;3(8-9):1324-35.
合成参考文献
参考文献:10.1107/s1600536811014012 摘要:Bi Y. 4-Meth-oxy-N'-(4-meth-oxy-benzyl-idene)benzohydrazide. Acta Crystallogr Sect E Struct Rep Online. 2011 May 01;67(Pt 5):o1182.