专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-4145346-A 优先权日:1977-10-03 标题 :Preparation of 3β-hydroxy-27-norcholest-5-ene-25-one and intermediates thereof 发明人:JONES HOWARD; FRANKSHUN ROBERT A 权利人:MERCK & CO INC 摘要:A process for preparing 3β-hydroxy-27-norcholest-5-ene-25-one, a useful intermediate in the synthesis of 25-acetoxy vitamin D 3 , novel intermediates, and preparation thereof are disclosed.
专利号:US-4105660-A 优先权日:1977-06-29 标题:Preparation of 3β-hydroxy-27-norcholest-5,7-dien-25-one 发明人:JONES HOWARD 权利人:MERCK & CO INC 摘要:Improved process is described for preparing 3β-hydroxy-27-norcholest-5,7-dien-25-one, a useful intermediate in the synthesis of 25-hydroxyvitamin D 3 . Novel intermediates and their preparation are disclosed.
专利号:US-7825268-B2 优先权日:2003-12-23 标 题:Alkoxylactones, alkoxylactams and alkoxythiolactams for controlling processes based on microbial interaction 发明人:STUMPE STEFAN; BREVES ROLAND; HUCHEL URSULA; JANSSEN FRANK; HAETZELT ANDRE 权利人:HENKEL AG & CO KGAA 摘要:Compounds of the Formula I, n nwherein A 1 is O or NH; A 2 is O or S; each of R 1 and R 2 is independently hydrogen, a methyl or C 2 -C 8 -saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group; and R 3 is a C 1 -C 18 -saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group wherein, each of R 1 , R 2 and R 3 comprises a heteroatom selected from the group consisting of O and S in the chain and/or is mono- or multiply-substituted by a substituent selected from the group consisting of halogen, hydroxy, C 1 -C 6 -alkyl, trifluoromethyl, C 1 -C 6 -alkoxy, C 6 -C 10 -aryl, and C 1 -C 6 -alkyl-C 6 -C 10 -aryl are useful for controlling the interaction process between microorganisms such as in the development and/or maturation of biofilms; multicellular swarm behavior; the concerted development of antibiotic resistances; the concerted synthesis of antibiotics; the concerted synthesis of pigments; the concerted production of extracellular enzymes; or the concerted production of virulence factors.
专利号:US-11414365-B2 优先权日:2018-01-30 标题:Natural 1,2-alkanediols, compositions having natural 1,2-alkanediols and processes for making the same 发明人:BURGO ROCCO V; WRIGHT MICHAEL E; MOSSER GARY B; FEVOLA MICHAEL J 权利人:INOLEX INVESTMENT CORP 摘要:A process is incorporated herein for the synthesis of bio-1,2-alkanediols, comprising: providing a bio-alkene having a carbon chain of about 5 to about 20 carbon atoms and a bio-1-alkene regioselectivity of at least about 80%, at least about 92% and/or at least about 95%; and converting the bio-alkene to a bio-1,2-alkanediol having a carbon chain length of about 5 to about 20 carbon atoms. Methods for treating catalysts which may be incorporated in the process for the synthesis of bio-1,2-alkanediols are also included herein. Such bio-1,2-alkanediols are used in compositions and products alone as antimicrobial materials, or with existing bio-compounds and/or antimicrobials, preservatives, alternative preservation systems and/or hurdle technology components. The bio-1,2-alkanediols incorporate a natural and bio-based pathway for antimicrobial effects in various compositions such as cosmetic, pharmaceutical, industrial and household products.
专利号:US-11780883-B2 优先权日:2021-06-30 标题 :Derived peptide of lactoferrin and method thereof for promoting and/or increasing lipid synthesis 发明人:HUANG HSIU-CHIN; LIN HSUAN 权利人:RENORIGIN INNOVATION INST CO LTD 摘要:The present invention provides a derived peptide of a lactoferrin, a composition comprising the same and a use thereof for promoting and/or increasing lipid synthesis. The derived peptide of the lactoferrin comprises the amino acid sequence of SEQ ID NO: 01.
参考文献:10.1111/j.1875-595x.2011.00042.x 摘要:Bosma ML. Maintenance of gingival health post professional care. International Dental Journal. 2011 Aug;61():1–3. doi: 10.1111/j.1875-595x.2011.00042.x. 参考文献:10.1111/j.1875-595x.2011.00044.x 摘要:Kakar A, Newby EE, Kakar K, Ghosh S, Targett D, Bosma ML. A randomised clinical trial to assess maintenance of gingival health by a novel dentifrice containing 0.1%w/w o-cymen-5-ol and 0.6%w/w zinc chloride. International Dental Journal. 2011 Aug;61():13–20. doi: 10.1111/j.1875-595x.2011.00044.x. 参考文献:10.1111/j.1875-595x.2011.00045.x 摘要:Kakar A, Newby EE, Ghosh S, Butler A, Bosma ML. A randomised clinical trial to assess maintenance of gingival health by a novel gel to foam dentifrice containing 0.1%w/w o-cymen-5-ol, 0.6%w/w zinc chloride. International Dental Journal. 2011 Aug;61():21–7. doi: 10.1111/j.1875-595x.2011.00045.x. 参考文献:10.1111/j.1875-595x.2011.00046.x 摘要:Butler A, Targett D, Bosma ML. Maintenance of gingival health – a measure based on clinical indices. International Dental Journal. 2011 Aug;61():28–32. doi: 10.1111/j.1875-595x.2011.00046.x. 参考文献:10.1111/j.1875-595x.2011.00047.x 摘要:Pizzey RL, Marquis RE, Bradshaw DJ. Antimicrobial effects of o-cymen-5-ol and zinc, alone & in combination in simple solutions and toothpaste formulations. International Dental Journal. 2011 Aug;61():33–40. doi: 10.1111/j.1875-595x.2011.00047.x.