CAS: 24915-04-6; (7S,7As,14S,14As)-Dodecahydro-2H,6H-7,14-Methanodipyrido[1,2-A:1',2'-E][1,5]Diazocine

上下游产品

1,5-diaminopentane dihydr°Chloride 2,3,4,5-tetrahydropyridine d,l-lupanine(-)-sparteine t)-1,3,4,7,9,10,11,13,14,14a-decahydro-2H,6H-7r,14c-methano-dipyrido[1,2-a;1',2'-e][1,5]diaz°Cine(+/-)-(14at)-1,3,4,7,9,10,11,13,14,14a-decahydro-2H,6H-7r,14c-methano-dipyrido[1,2-a;1',2'-e][1,5]diaz°Cine c,14at)-dodecahydro-7r,14c-methano-dipyrido[1,2-a;1',2'-e][1,5]diaz°Cin-6-one(+/-)-(7ac,14at)-dodecahydro-7r,14c-methano-dipyrido[1,2-a;1',2'-e][1,5]diaz°Cin-6-one 17-phenyl-16,17-dehydrosparteinium hydroxide

专利信息

专利号:US-2012302756-A1
优先权日:2010-02-19
标 题 :Process for synthesis of 2-substituted pyrrolidines and piperadines
发明人：LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
权利人:LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
摘要:The present invention provides a highly efficient, versatile one-step process for asymmetric synthesis of either diastereomer of 2-substituted pyrrolidines from a single starting material with excellent yields and high diastereoselectivety. Also provided is a method for the asymmetric synthesis of both diastereomers of 2-substituted piperidines with good yields and excellent diastereoselectivety. Diasteroselectivity is controlled effectively by choice of reducing agent.

专利号:US-2024400517-A1
优先权日:2022-02-08
标 题 :Chiral bimetallic cooperative catalysis system and use thereof in asymmetric synthesis of bedaquiline
发明人：ZHANG WANBIN; GAO FENG; LI JING; AHMAD TANVEER; ZHANG ZHENFENG; YUAN QIANJIA
权利人:UNIV SHANGHAI JIAOTONG
摘要:A chiral bimetallic cooperative catalysis system and use thereof in asymmetric synthesis of bedaquiline are provided. Specifically, the chiral bimetallic cooperative catalysis system is formed by a metallic lithium, sodium or potassium salt and another metal salt under the action of a suitable ligand and an additive. By means of the chiral bimetallic cooperative catalysis system, an addition reaction of 6-bromo-3-benzyl-2-methoxyquinoline (I) and 3-dimethylamino-1-naphthyl-1-propanone (II) is promoted, the selectivity is regulated, and a target product, (1R,2S)-bedaquiline, with high yield and high selectivity is obtained for the first time.

专利号:US-8283502-B2
优先权日:2009-04-09
标题:Autocatalytic process for the synthesis of chiral propargylic alcohols
发明人：CHINKOV NICKA; WARM ALEKSANDER; CARREIRA ERICK
权利人:CHINKOV NICKA; WARM ALEKSANDER; CARREIRA ERICK; LONZA AG
摘要:An autocatalytic process for the synthesis of chiral propargylic alcohols.

专利号:US-5973161-A
优先权日:1996-03-18
标 题:Enantioselective synthesis of cyclopentenes
发明人：CRIMMINS MICHAEL T
权利人:UNIV NORTH CAROLINA
摘要:Methods of synthesizing compounds of the Formula V: ##STR1## wherein X c is a chiral auxiliary, m is from 1 to 4, and R 8 is hydrogen or --OH, are provided. n Additionally, methods of synthesizing compounds of the Formula XII: ##STR2## wherein m is from 1-4; B is hydrogen or a blocking group; and R 13 is a leaving group or a compound of formula R 14 --N--R 15 ; n wherein R 14 is hydrogen or branched or straight-chain C1-C6 alkyl; and R 15 is hydrogen, C3-C8 cycloalkyl, or branched or straight-chain alkyl; n are also provided. Novel compounds useful in the synthesis of cyclopentenes and carbocyclic nucleosides are further provided.

专利号:EP-2280974-B1
优先权日:2008-04-30
标题:Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：REEVES JONATHAN TIMOTHY; SONG JINHUA J; TAN ZHULIN
权利人:BOEHRINGER INGELHEIM INT; BOEHRINGER INGELHEIM PHARMA
摘要:A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.

专利号:US-7425629-B2
优先权日:2005-09-30
标 题:Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：SONG JINHUA J; REEVES JONATHAN T; ROSCHANGAR FRANK; TAN ZHULIN; YEE NATHAN K
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:A process for stereoselective synthesis of a compound of Formula (I) n nwherein R 1 , R 2 , R 3 , R 4 , and R 5 are as described herein.