CAS: 24587-37-9; (S)-2-((S)-2-Amino-3-Methylbutanamido)-3-(1H-Indol-3-yl)Propanoic Acid

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CAS号18904-53-5 Z-Val-Trp-OH | CAS号72-18-4 l-缬氨酸 | CAS号73-22-3 L-色氨酸

Z-Val-Trp-Oh置于palladium On Activated Charcoal 氢气体系中,用 甲醇 用作溶剂,以2.04 G的收率获得l-缬氨酰-L-酪氨酸
参考文献:某些含色氨酸二肽与金属离子的配位化合物的合成及免疫刺激活性
标题:某些含色氨酸二肽与金属离子的配位化合物的合成及免疫刺激活性
摘要:一种提高母体化合物比活性并减少其副作用的有前途的方法是与金属离子形成配位化合物 [1].潜在的配体由含有色氨酸的二肽提供,其通式为 Hx-Trp-Oh(x = Glu,Asp,Leu,Ile),具有免疫刺激活性 [2 4].我们合成了一系列具有fe 2+ 和zn 2+ 离子的配位化合物并研究了它们的免疫活性.二肽 H-Val-Trp-Oh 和 H-Ile-Trp-Oh 使用在二(五氟苯基)碳酸酯的帮助下获得的活化(五氟苯基)酯合成.当用常规方法与五氟苯基酯进行缩合反应时,有必要引入带有受保护的 Ct-羧基的氨基组分,并以单独的形式使用 N-受保护氨基酸的五氟苯基酯.这意示需要额外的步骤来分离和纯化 N 保护氨基酸的五氟苯基酯,以及从色氨酸的羧基中引入和去除保护.氨基酸的α-羧基被苯甲氧基保护.借助二(五氟苯基)碳酸酯获得n-保护氨基酸的五氟苯基酯.N-保护氨基酸的三乙基铵盐 (10 毫摩尔)
Doi:10.1007/bf02524630

专利信息

专利号:US-5144073-A
优先权日:1988-08-31
标 题 :Process for preparation of dipeptides
发明人：HUBBS JOHN C
权利人:HUBBS JOHN C
摘要:Disclosed is a process for synthesis of a dipeptide such as N-acetyl-L- alpha -aspartyl-L-phenylalanine methyl ester wherein one amino acid serves as a chiral template which allows for synthesis of a second amino acid residue to form said dipeptide. The process involves several novel steps such as a nucleophile addition step. In addition, several novel intermediates are described.

专利号:US-6664282-B2
优先权日:1999-09-17
标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds
发明人：ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TORREY PINES INST
摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.

专利号:EP-2588602-A1
优先权日:2010-07-01
标题:Variants of glucoamylase
发明人：DEGN PETER EDVARD; BOTT RICHARD R; VROEMEN CASPER WILLEM; SCHEFFERS MARTIJN SILVAN; AEHLE WOLFGANG; PETERSEN ELIN
权利人:DUPONT NUTRITION BIOSCI APS; DANISCO US INC
摘要:The present invention relates to combinatorial variants of a parent glucoamylase that have altered properties for reducing the synthesis of condensation products during hydrolysis of starch. Accordingly the variants of a parent glucoamylase are suitable such as for use within brewing and glucose syrup production. Also disclosed are DMA constructs encoding the variants and methods of producing the glucoamylase variants in host cells.

专利号:US-2006217788-A1
优先权日:2004-07-09
标 题:Method of using laser induced injury to activate topical prodrugs
发明人：HERRON G S; BOMMANNAN D B
权利人:HERRON G S; BOMMANNAN D B
摘要:Methods and compositions are disclosed for improving the wound healing process and increasing collagen synthesis following laser induced thermal injury. The method comprises delivering prodrugs to a target site before the target site is injured and taking advantage of those enzymes that are physiologically-expressed to promote wound healing to convert the prodrugs to active drugs. The claimed invention has the advantage of the prodrugs being readily available to immediately participate in the wound healing process, but not have any negative side-effects of the active drug being present before injury occurs.

专利号:WO-2009056901-A1
优先权日:2007-10-31
标题:Cyclodipeptide synthases (cdss) and their use in the synthesis of linear dipeptides

专利号:WO-0119783-A1
优先权日:1999-09-17
标 题:Synthesis of [3,5,7]-1h-imidazo[1,5-a]imidazol-2(3h)-one compounds