专利号:US-9969686-B2 优先权日:2014-08-05 标 题 :Synthesis of diindolylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them 发明人:TANG WEIPING; LI XIAOXUN; SHU DONGXU; WINSTON-MCPHERSON GABRIELLE N 权利人:WISCONSIN ALUMNI RES FOUND 摘要:Described is a method to make diindolylmethanes and indolyl/pyrrolylmethanes, The method includes the steps of contacting an ether comprising an arylpropargyl moiety and an amine-protected, substituted or unsubstituted aniline moiety with a substituted or unsubstituted indol or a substituted or unsubstituted pyrrole, in the presence of a metal-containing catalyst, for a time and at a temperature to cause an annulation/arylation cascade reaction that yields a diindolylmethane or a indolyl/pyrrolylmethane. The resulting compounds are effective to modulate activity of arylhydrocarbon receptors, to inhibit activity of PCSK9, and to stimulate secretion of glucagon-like peptide 1 in mammals.
专利号:US-2014076403-A1 优先权日:2012-05-15 标 题 :Dipyrin based materials for photovoltaics, compounds capable of undergoing symmetry breaking intramolecular charge transfer in a polarizing medium and organic photovoltaic devices comprising the same 发明人:FORREST STEPHEN R; THOMPSON MARK E; CHEN JOHN J; SOMMER JONATHAN R; DJUROVICH PETER I; ALLEN KATHRYN R 权利人:UNIV SOUTHERN CALIFORNIA; UNIV MICHIGAN 摘要:The present disclosure generally relates to organic photosensitive optoelectronic devices comprising at least one boron dipyrrin compound. In addition, the present disclosure relates to methods of making organic photosensitive optoelectronic devices comprising at least one boron dipyrrin compound. The present disclosure also generally relates to chromophoric compounds that combine strong absorption of light at visible wavelengths with the ability to undergo symmetry-breaking intramolecular charge transfer (ICT), and their use for the generation of free carriers in organic photovoltaic cells (OPVs) and electric-field-stabilized geminate polaron pairs. The present disclosure also relates to the synthesis of such compounds, methods of manufacture, and applications in photovoltaic systems and organic lasers.
专利号:WO-2025083716-A1 优先权日:2023-10-20 标题 :Bisindole based compounds and salts thereof, and their process of preparation under electrochemical setup 发明人:PRASAD BHAGAVATULA LAKSHMI VARA; BARAVKAR MAYUR DILIP 权利人:COUNCIL SCIENT IND RES 摘要:The present disclosure generally relates to synthetic heteroaromatic compounds specifically synthesis of natural based compounds via electrochemical mode. The present disclosure relates to (un)substituted bisindole based compound, stereoisomer, racemate or pharmaceutically acceptable salt and method for preparation thereof via electrochemical synthetic mode. More specifically, the present invention relates to preparation of Vibrindole A and related natural based compounds of formula I via electrochemical synthetic mode.
专利号:US-8399502-B2 优先权日:2008-09-17 标 题 :Analogs of indole-3-carbinol and their use as agents against infection 发明人:JONG LING; JIANG FAMING; LI GAOQUAN; MORTELMANS KRISTIEN 权利人:JONG LING; JIANG FAMING; LI GAOQUAN; MORTELMANS KRISTIEN; STANFORD RES INST INT 摘要:Compounds useful as antibacterial agents are provided. The compounds are analogs of indole-3-carbinol and have a backbone selected from dihydroindolo[2,3-b]carbazole, 2,2′-diindolylmethane, 2′,3-diindolylmethane, and 3,3′-diindolylmethane. The compounds are useful therapeutic and prophylactic treatment of bacterial infections in mammals. Methods of synthesis of the compounds are provided, as are pharmaceutical compositions containing the compounds.
专利号:US-2014357576-A1 优先权日:2013-05-31 标题:Methods for enhancement of muscle protein synthesis 发明人:BREUILLE DENIS; STELLINGWERFF TRENT; MOORE DANIEL RYAN; OFFORD CAVIN ELIZABETH ANN; PHILLIPS STUART MARTIN 权利人:NESTEC SA 摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis by enhancing myofibrillar muscle protein synthesis. The method includes administering to the individual a mixed macronutrient composition having (i) an amount of whey protein that is not capable of enhancing myofibrillar protein synthesis when ingested by itself and (ii) free leucine. The composition comprises at least about 5.0 g total leucine per dose.
专利号:WO-2015040533-A1 优先权日:2013-09-19 标题:Methods for enhancing muscle protein synthesis during energy deficit 发明人:BAILEY DAVID MARK; ZALTAS ERIC SCOTT; STELLINGWERFF TRENT; MOORE DANIEL RYAN; HAWLEY JOHN ALAN; BURKE LOUISE MARY 权利人:PREMIER NUTRITION CORP 摘要:The present disclosure provides methods for enhancing muscle protein synthesis in an individual in need of same. Specifically, the present disclosure provides methods for enhancing muscle protein synthesis during periods of negative energy balance, or energy deficit. The methods include administering to an individual suffering from energy deficit a composition comprising protein in an amount from about 15 g to about 30 g during a time period selected from the group consisting of during exercise, post-exercise, and combinations thereof. The methods also include administering to an individual suffering from energy deficit a composition comprising protein during a time period selected from the group consisting of during exercise, post-exercise, and combinations thereof, wherein the protein is administered in a dose that is higher than doses typically recommended for individuals experiencing energy balance.
1: Yang H, Seo SG, Shin SH, Min S, Kang MJ, Yoo R, Kwon JY, Yue S, Kim KH, Cheng JX, Kim JR, Park JS, Kim JH, Park JHY, Lee HJ, Lee KW. 3,3'-Diindolylmethane suppresses high-fat diet-induced obesity through inhibiting adipogenesis of pre-adipocytes by targeting USP2 activity. Mol Nutr Food Res. 2017 Jun 6. doi: 10.1002/mnfr.201700119. [Epub ahead of print] doi: 10.1007/978-1-4939-7104-6_19. doi: 10.1016/j.jnutbio.2017.05.005. [Epub ahead of print] [Study of algorithms to identify schizophrenia in the SNIIRAM database conducted by the REDSIAM network]. Rev Epidemiol Sante Publique. 2017 May 30. pii: S0398-7620(17)30405-4. doi: 10.1016/j.respe.2017.03.133. [Epub ahead of print] French. doi: 10.3760/cma.j.issn.0253-2727.2017.05.009. Chinese. doi: 10.1016/j.scr.2017.05.004. [Epub ahead of print] Impact of days in milk at the initiation of ovulation synchronization protocols on the efficiency of first AI in multiparous Holstein cows. Anim Reprod Sci. 2017 May 17. pii: S0378-4320(17)30081-7. doi: 10.1016/j.anireprosci.2017.05.005. [Epub ahead of print] Understanding the reconstitution of the B-cell compartment in bone marrow and blood after treatment for B-cell precursor acute lymphoblastic leukaemia. Br J Haematol. 2017 May 25. doi: 10.1111/bjh.14685. [Epub ahead of print]
合成参考文献
参考文献:10.1007/s11010-011-0985-0 摘要:Jin Y. 3,3′-Diindolylmethane inhibits breast cancer cell growth via miR-21-mediated Cdc25A degradation. Molecular and Cellular Biochemistry. 2011 Jul 15;358(1-2):345. doi: 10.1007/s11010-011-0985-0. 参考文献:10.1080/01635581.2011.570896 摘要:Saati GE, Archer MC. Inhibition of fatty acid synthase and Sp1 expression by 3,3'-diindolylmethane in human breast cancer cells. Nutr Cancer. 2011;63(5):790–4. doi: 10.1080/01635581.2011.570896.