📜氯甲酸苄酯置于碳酸氢钠,N,N'-二环己基碳二亚胺体系中,用 乙酸乙酯 用作溶剂,化学反应 1.5H,反应生成N-苄氧羰基甘氨酸-4-硝基苯酯 参考文献:Correlative Variations In Enzyme-Derived And Substrate-Derived Structures Of Catalytic Transition States. Implications For The Catalytic Strategy Of Acyl-Transfer Enzymes 标题:Correlative Variations In Enzyme-Derived And Substrate-Derived Structures Of Catalytic Transition States. Implications For The Catalytic Strategy Of Acyl-Transfer Enzymes 摘要: Doi:10.1021/ja00346A056
专利号:US-11634741-B2 优先权日:2013-11-20 标 题:Synthesis of L-nucleic acids by means of an enzyme 发明人:PECH ANDREAS; JAROSCH FLORIAN; JAHNZ MICHAEL; KLUSSMANN SVEN; DAVID RALF 权利人:APTARION BIOTECH AG 摘要:The present invention is related to a method for adding one or more L-nucleotides to the 3′end of a first L-nucleic acid, wherein the method comprises the step of reacting the one or more L-nucleotides with the first L-nucleic acid in the presence of a protein comprising a mutant enzymatic activity exhibiting moiety, wherein the enzymatic activity is capable of adding one or more L-nucleotides to the 3′ end of the first L-nucleic acid, wherein the mutant enzymatic activity exhibiting moiety comprises an amino acid sequence, wherein the amino acids of the amino acid sequence are D-amino acids, wherein the mutant enzymatic activity exhibiting moiety is a variant of an enzymatic activity exhibiting moiety, wherein the enzymatic activity exhibiting moiety consists of an amino acid sequence according to SEQ ID NO: 15 and wherein the amino acids of the amino acid sequence according to SEQ ID NO: 15 are D-amino acids, wherein the amino acid sequence of the mutant enzymatic activity exhibiting moiety differs from the amino acid sequence of the enzymatic activity exhibiting moiety consisting of an amino acid sequence according to SEQ ID NO: 15 at least at one amino acid position, preferably at three amino acid positions, and/or wherein the amino acid sequence of the mutant enzymatic activity exhibiting moiety is a truncated form of an amino acid sequence according to SEQ ID NO: 15, and wherein the amino acid sequence of the mutant enzymatic activity exhibiting moiety is different from an amino acid sequence according to any of SEQ ID NOs 15 to 22 and 51.
专利号:EP-3071702-B1 优先权日:2013-11-20 标题 :Synthesis of l-nucleic acids by means of an enzyme
专利号:US-3137684-A 优先权日:1962-05-29 标 题 :Preparation of phenyl esters via alkoxyvinyl and alkoxyacetylene intermediates and use thereof in peptide synthesis 发明人:MIKLOS BODANSZKY 权利人:OLIN MATHIESON
参考标题:Synthèse D'Analogues Structuraux De L'élédoïsine. 1RePartie: Préparation Des Produits Intermédiaires 作者:Ed. Sandrin,R. A. Boissonnas 摘要:The Preparation Of New Dipeptides And Tripeptides, Which Are Useful Intermediates In The Synthesis Of Eledoisin Analogues, Is Described.
合成参考文献
参考文献:10.1021/jm00151a018 摘要:Thompson SA, Andrews PR, Hanzlik RP. Carboxyl-modified amino acids and peptides as protease inhibitors. J Med Chem. 1986 Jan;29(1):104–11. doi: 10.1021/jm00151a018.