CAS: 1738-86-9; 4-Nitrophenyl ((Benzyloxy)Carbonyl)Glycinate

该化合物是一种化学化合物,其结构特征是其结构,包括由苯基氧碳基(Z)组和以4-硝酸酯组成的酯加以保护的甘基辛酸,该化合物一般用于浸渍合成中,因为其有能力促进形成peptide 键;Z组是一个保护性群体,可在特定条件下予以消除,允许有选择地去保护氨基酸;4-硝基苯酯的存在加强了碳箱酸成分的再活动,使其成为有机合成中的有用建筑块;Z-glycine 4-硝基苯基酯在标准实验室条件下一般保持稳定,但应当谨慎处理,因为硝基苯基苯组具有潜在的再活性;其应用范围扩大到生物化学和药化学,特别是在开发基于浸药的药物和研究酶机制方面.

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相似化合物

3655-05-8 1168-87-2 17639-39-3

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CAS号100-02-7 对硝基苯酚 | CAS号1138-80-3 N-苄氧羰基甘氨酸 | CAS号501-53-1 氯甲酸苄酯 | CAS号7693-46-1 对硝基苯基氯甲酸酯 | CAS号25887-81-4 Sulfurous acid,... | CAS号23485-35-0 tris(4-nitrophe... | CAS号949-90-6 N-苄氧羰基甘氨酰胺 | CAS号100-02-7 对硝基苯酚 | CAS号21855-75-4 Benzyl N-[(buty... | CAS号1138-80-3 N-苄氧羰基甘氨酸 | CAS号2566-19-0 N-苄氧羰基-甘氨酰甘氨酸 | CAS号1160-54-9 N-苄氧羰基甘氨酰-L-脯氨酸 | CAS号1170-76-9 N-苄氧羰基甘氨酰-L-苯丙氨酸 | CAS号3249-01-2 ethyl 3-(4-hydr... | CAS号3079-63-8 Z-Gly-Ala-OH | CAS号17639-39-3 4-硝基苯基甘氨酸

合成工艺路线路线简述

  • 合成目标产物 Z-Gly-Onp 主要起始原料 Benzyl Chloroformate
  • (文献来源)合成步骤主要原料 Benzyl Chloroformate
📜氯甲酸苄酯置于碳酸氢钠,N,N'-二环己基碳二亚胺体系中,用 乙酸乙酯 用作溶剂,化学反应 1.5H,反应生成N-苄氧羰基甘氨酸-4-硝基苯酯
参考文献:Correlative Variations In Enzyme-Derived And Substrate-Derived Structures Of Catalytic Transition States. Implications For The Catalytic Strategy Of Acyl-Transfer Enzymes
标题:Correlative Variations In Enzyme-Derived And Substrate-Derived Structures Of Catalytic Transition States. Implications For The Catalytic Strategy Of Acyl-Transfer Enzymes
摘要:
Doi:10.1021/ja00346A056

海关参考信息

专利信息


专利号:US-11634741-B2
优先权日:2013-11-20
标 题:Synthesis of L-nucleic acids by means of an enzyme
发明人:PECH ANDREAS; JAROSCH FLORIAN; JAHNZ MICHAEL; KLUSSMANN SVEN; DAVID RALF
权利人:APTARION BIOTECH AG
摘要:The present invention is related to a method for adding one or more L-nucleotides to the 3′end of a first L-nucleic acid, wherein the method comprises the step of reacting the one or more L-nucleotides with the first L-nucleic acid in the presence of a protein comprising a mutant enzymatic activity exhibiting moiety, wherein the enzymatic activity is capable of adding one or more L-nucleotides to the 3′ end of the first L-nucleic acid, wherein the mutant enzymatic activity exhibiting moiety comprises an amino acid sequence, wherein the amino acids of the amino acid sequence are D-amino acids, wherein the mutant enzymatic activity exhibiting moiety is a variant of an enzymatic activity exhibiting moiety, wherein the enzymatic activity exhibiting moiety consists of an amino acid sequence according to SEQ ID NO: 15 and wherein the amino acids of the amino acid sequence according to SEQ ID NO: 15 are D-amino acids, wherein the amino acid sequence of the mutant enzymatic activity exhibiting moiety differs from the amino acid sequence of the enzymatic activity exhibiting moiety consisting of an amino acid sequence according to SEQ ID NO: 15 at least at one amino acid position, preferably at three amino acid positions, and/or wherein the amino acid sequence of the mutant enzymatic activity exhibiting moiety is a truncated form of an amino acid sequence according to SEQ ID NO: 15, and wherein the amino acid sequence of the mutant enzymatic activity exhibiting moiety is different from an amino acid sequence according to any of SEQ ID NOs 15 to 22 and 51.

专利号:EP-3071702-B1
优先权日:2013-11-20
标题 :Synthesis of l-nucleic acids by means of an enzyme

专利号:US-3137684-A
优先权日:1962-05-29
标 题 :Preparation of phenyl esters via alkoxyvinyl and alkoxyacetylene intermediates and use thereof in peptide synthesis
发明人:MIKLOS BODANSZKY
权利人:OLIN MATHIESON

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📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

参考标题:Synthèse D'Analogues Structuraux De L'élédoïsine. 1RePartie: Préparation Des Produits Intermédiaires
作者:Ed. Sandrin,R. A. Boissonnas
摘要:The Preparation Of New Dipeptides And Tripeptides, Which Are Useful Intermediates In The Synthesis Of Eledoisin Analogues, Is Described.

合成参考文献


参考文献:10.1021/jm00151a018
摘要:Thompson SA, Andrews PR, Hanzlik RP. Carboxyl-modified amino acids and peptides as protease inhibitors. J Med Chem. 1986 Jan;29(1):104–11. doi: 10.1021/jm00151a018.
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