CAS: 16618-72-7; 3-Phenyl-2,3-Dihydro-1H-Inden-1-One

该化合物是一种多用途有机化合物,其特点是在三点位置用一个苯基组替代一个装有引信的因丹内核核心,这种结构具有独特的反应性,使其成为合成有机化学,特别是制药,农用化学品和功能材料的制作方面的宝贵中间体,其硬性双环框架增强了稳定性,同时允许反应场所有选择地发挥功能.该化合物通常用于循环反应,催化转化和作为生物活性分子的前体.可得到高纯度的等级,以确保研究和工业应用的一贯性.其定义明确的晶体形式有利于处理和储存.

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30516-40-6 865189-98-6 262433-38-5

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上下游产品

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合成工艺路线路线简述

  • 合成目标产物 3-Phenyl-1-Indanone 主要起始原料 3-Phenyl-1-Indanol
  • (文献来源)合成步骤主要原料 3-Phenyl-1-Indanol
📜亚苯甲基丙二酸二乙酯置于氢氧化钾,Ppa,Polyphosphoric Acid (Ppa),Magnesium,Copper(I) Bromide体系中,用 甲醇 用作溶剂,化学反应 10.5H,反应生成3-苯基-1-茚酮
参考文献:Patra; Kumar Misra,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,1990,Vol. 29,# 1,P. 66-69
标题:Patra; Kumar Misra,Indian Journal Of Chemistry-Section B Organic And Medicinal Chemistry,1990,Vol. 29,# 1,P. 66-69

海关参考信息

专利信息


专利号:US-6268535-B1
优先权日:1998-01-09
标题 :Synthesis of 3-aryl-1-indanamines
发明人：MOUSSA ADEL M; HAIDER REEM; TAFT HEATHER; JURAYJ JURJUS; WANG WEIHENG; SUH HAESUK
权利人:PHARM ECO LAB INC
摘要:The present invention is a method of preparing a 3-aryl-1-indanamine represented by structural formula I:and physiologically acceptable salts thereof.In structure I, phenyl ring A can be unsubstituted or substituted with 1-4 substitutents.R1 is an aromatic group which can be substituted or unsubstituted.R2 and R3 are each, independently, hydrogen, an aliphantic group, a substituted aliphatic group, an aromatic group, a substituted aromatic group, an aralkyl group, or a substituted aralkyl group. Alternatively, R2 and R3, taken together with the nitrogen substitutent on the indan ring, form a non-aromatic ring system having 1-2 heteroatoms.

专利号:US-5948807-A
优先权日:1997-09-03
标 题 :Spiroindanamines and Spiroindanimides
发明人：EFANGE S MBUA NGALE; MASH DEBORAH CARMEN
权利人:UNIV MINNESOTA
摘要:Compounds of formula I: ##STR1## wherein R 1 , R 2 , W, X, Y and Z have any of the values defined in the specification, and their pharmaceutically acceptable salts, are inhibitors of monoamine re-uptake and are useful for treating diseases in mammals wherein insufficient synaptic levels of monoamine are implicated. Also disclosed are pharmaceutical compositions, processes for preparing compounds of formula I, and intermediates useful for the synthesis of compounds of formula I.

专利号:RU-2179561-C2
优先权日:1996-05-09
标 题:Method of synthesis of high-elastic copolymers ep(d)m, compound

专利号:WO-9935119-A1
优先权日:1998-01-09
标 题:Synthesis of 3-aryl-1-indanamines

专利号:RU-2768714-C2
优先权日:2020-05-22
标题 :Method for synthesis of 3-arylindan-1-ones by reaction of super-electrophilic aromatic substitution of cinnamic nitriles

专利号:JP-2002500211-A
优先权日:1998-01-09
标 题:Synthesis of 3-aryl-1-indanamine

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合成参考文献


摘要:Merino, P., Science of Synthesis, (2010) 45, 289.
摘要:Sharma, U.; Kumar, R.; Gupta, S. S.; Chandra, D., Science of Synthesis Knowledge Updates, (2022) 2, 188.
摘要:Watson, I. D. G.; Toste, F. D., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 292.
摘要:Elie, M.; Renaud, J.-L.; Gaillard, S., Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (2016) 1, 199.
摘要:Calleja, P.; Dorel, R.; Echavarren, A. M., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 508.
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