CAS: 1611-31-0; Diisopropyl Hydrogen Phosphate

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📜沙林置于li8(Hexaniobate),水体系中,化学反应生成氢磷酸二异丙酯
参考文献:用聚氧铌酸盐降解神经毒剂
标题:用聚氧铌酸盐降解神经毒剂
摘要:聚氧铌酸盐在多金属氧酸盐中是特殊的,因为它们可以潜在地在水中进行碱催化,这是一个质子与氧代配体键合并释放羟基的过程.最近在叙利亚臭名昭著的平民袭击中使用的化学战剂(例如有机氟磷酸盐)的催化分解是使用该过程的一个机会.在评估聚氧铌酸盐 Lindqvist 离子 [nb6O19]8-后,发现了神经毒剂模拟物氟磷酸二异丙酯 (Dfp) 分解的快速中和动力学.还针对神经毒剂沙林 (Gb) 和梭曼 (Gd) 对多氧铌酸盐进行了测试.已确定不同的 Lindqvist 抗衡阳离子(li,K 或 Cs)影响有机磷酸盐化合物在两种水性介质(均相反应)中的分解速率,和固态(非均相反应).对 [nb6O19]8-的 Li,K 和 Cs 盐溶液的小角度 X 射线散射分析显示,进行实验时的浓度存在明显差异,这可能与它们的相对反应速率有关.这项研究首次证明了利用聚氧铌酸盐的独特碱性反应进行神经毒剂净化.
Doi:10.1002/ejic.201400016

专利信息

专利号:US-2024024497-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to methods for the synthesis of conjugates useful for the treatment of viral infections, e.g., conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir or an analog thereof) linked to an Fc domain monomer.

专利号:US-11738092-B2
优先权日:2019-12-04
标题:Methods and compositions for synthesis of therapeutic nanoparticles
发明人：WYENT EMILY A; BLUMENFELD CARL M; LAMM ROBERT J
权利人:DANTARI INC
摘要:Improved methods and reactants for the chemical synthesis of therapeutic nanoparticles are provided. The nanoparticles comprise a polymeric core, to which is attached one or more homing molecules and one or more therapeutic agents. Improvements in speed, yield and purity are attained using the methods disclosed herein.

专利号:US-10927135-B2
优先权日:2017-08-03
标 题:Metal-free direct arylation of dialkyl phosphonates for the synthesis of mixed alkyl aryl phosphonates
发明人：KANG JUN YONG; HUANG HAI
权利人:THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIV OF NEVADA LAS VE
摘要:Provided herein are phosphates, thiophosphates, phosphonates, and phosphinates, methods of making same, and methods of using these compounds and methods for the generation of pharmaceutically relevant phosphate, phosphonate, and phosphinate analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-7521504-B2
优先权日:2001-07-24
标 题:Irreversible immobilization of enzymes into polyurethane coatings
发明人：RUSSELL ALAN J; DREVON GERALDINE F; WICKS DOUGLAS A; DANIELMEIER KARSTEN
权利人:UNIV PITTSBURGH
摘要:A method of irreversibly immobilizing an enzyme in a polyurethane and an enzyme-containing polyurethane having a degree of immobilization of the enzyme of approximately 100%. The synthesis of waterborne polyurethanes in the presence of enzyme has enabled the irreversible attachment of the enzyme to the polymeric matrix. The distribution of immobilized enzyme as well as activity retention are homogeneous within the polyurethane. Decreasing ECC hydrophobicity, via the use of a less hydrophobic polyisocyanate prepolymer during polymerization, significantly enhanced the intrinsic activity of the ECC.

专利号:US-5239119-A
优先权日:1990-11-23
标题 :Catalytic synthesis of azines from H2 O2 /NH3 /carbonyl compounds
发明人：SCHIRMANN JEAN-PIERRE; TELLIER PIERRE
权利人:ATOCHEM
摘要:Azines are synthesized from aqueous hydrogen peroxide, ammonia and a carbonyl compound, e.g., acetone, methyl ethyl ketone or methyl isobutyl ketone, in the presence of a catalytically effective amount of immixture of an amide of a weak acid and an ammonium salt corresponding to such weak acid. A more general high output such process comprises (a) interreacting aqueous hydrogen peroxide, ammonia and a carbonyl compound in the presence of a catalytically effective amount of immixture comprising an amide of a weak acid, (b) separating the azine thus produced from the medium of reaction, (c) reconstituting the amount of the amide in the medium of reaction to the initial amount thereof present at the onset of step (a), and (d) recycling such reconstituted medium of reaction to step (a).

专利号:US-2023364251-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.