CAS: 14531-52-3; 5-Phenethylbenzene-1,3-Diol

相似化合物

37116-80-6 33675-75-1 90332-29-9

上下游产品

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3,5-二甲氧基苄醇置于palladium On Activated Charcoal 萘,氢溴酸,氢气,Lithium,溶剂黄146,三乙胺体系中,用 四氢呋喃,甲醇,水 用作溶剂,-30.0~20.0 °C,101.33 Kpa 条件下,反应 42.0H,反应生成二氢赤松素
参考文献:5位间苯二酚的简单合成:有趣的生物活性分子的再访家族.
标题:5位间苯二酚的简单合成:有趣的生物活性分子的再访家族.
摘要:3,5-二甲氧基苄基三甲基甲硅烷基醚(3)与不同醛(n-Prcho,Nc(11)h(23)cho,Mecho,Phcho)在锂粉和催化量萘(4 Mol)的存在下反应%)在水解后得到中等产率的预期醇4.这些化合物通过相应的甲磺酸酯5脱羟基或直接由苄基衍生物通过催化加氢脱羟基,得到化合物6,最后将其脱甲基,得到5-烷基-3,5-二羟基间苯二酚,例如橄榄酚(7A),格列维洛(7B),1,3-二羟基-5-丙基苯(7C)或二氢吡sil硅(7D).醇衍生物4脱水后再去甲基化,会生成羟基化的1,2-苯乙烯型结构,如宾诺硅碱(9D),白藜芦醇(9E)或甲基吡啶(9F),在某些情况下,可以将其氢化得到饱和分子,例如康普他汀b-4四甲基醚(6F)或金联双苄基(6G).最后,当在其他亲电子试剂[me(3)sicl,T-Bucho,Ch(3)(ch(2))(4)cho,4-Me(3)的存在下进行化合物3的萘催化
Doi:10.1021/jo9610624

专利信息

专利号:US-10981850-B2
优先权日:2019-04-15
标 题 :One-step flow-mediated synthesis of cannabidiol (CBD) and derivatives
发明人：PORCO JOHN A; BEELER AARON B; BROWN LAUREN E; TRILLES RICHARD V
权利人:UNIV BOSTON
摘要:Herein are described apparatus and processes for the preparation of cannabinoids, such as cannabidiol (CBD) and derivatives thereof. The apparatus and processes described can be used for the one-step, flow-mediated synthesis of cannabidiol and derivatives with improved overall yield, material throughput, and product purity relative to batch processes.

专利号:US-2024026314-A1
优先权日:2020-11-25
标题 :Polypeptides for use in the synthesis of bioactive phenolic compounds
发明人：ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN
权利人:ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN
摘要:Described herein is a polypeptide encoding a prenyltransferase for prenylating a polyphenol and a polypeptide encoding an O-methyltransferase for methylating a polyphenol. For example, the polypeptide comprises or consists of the sequence of SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or a polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a variant thereof having at least 80% sequence identity to SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or the polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a fragment of the polypeptide or the variant thereof.

专利号:WO-2020214574-A1
优先权日:2019-04-15
标 题 :One-step flow-mediated synthesis of cannabidiol (cbd) and derivatives

专利号:EP-4251758-A1
优先权日:2020-11-25
标 题:Polypeptides for use in the synthesis of bioactive phenolic compounds

专利号:WO-2022109736-A1
优先权日:2020-11-25
标题:Polypeptides for use in the synthesis of bioactive phenolic compounds

专利号:CA-3202377-A1
优先权日:2020-11-25
标题 :Polypeptides for use in the synthesis of bioactive phenolic compounds