CAS: 145224-95-9; L-Aspartyl-L-Aspartyl-L-Aspartyl-L-Aspartic Acid

专利信息

专利号:US-11851651-B2
优先权日:2017-06-19
标 题 :Automated methods for scalable, parallelized enzymatic biopolymer synthesis and modification using microfluidic devices
发明人：BANAL JAMES; BERLEANT JOSEPH DON; SHEPHERD TYSON; BATHE MARK
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Methods for the automated template-free synthesis of user-defined sequence controlled biopolymers using microfluidic devices are described. The methods facilitate simultaneous synthesis of up to thousands of uniquely addressed biopolymers from the controlled movement and combination of regents as fluid droplets using microfluidic and EWOD-based systems. In some forms, biopolymers including nucleic acids, peptides, carbohydrates, and lipids are synthesized from step-wise assembly of building blocks based on a user-defined sequence of droplet movements. In some forms, the methods synthesize uniquely addressed nucleic acids of up to 1,000 nucleotides in length. Methods for adding, removing and changing barcodes on biopolymers are also provided. Biopolymers synthesized according to the methods, and libraries and databases thereof are also described. Modified biopolymers, including chemically modified nucleotides and biopolymers conjugated to other molecules are described.

专利号:US-2018274001-A1
优先权日:2017-03-21
标 题 :Nucleic acid synthesis using dna polymerase theta
发明人：EFCAVITCH J WILLIAM; TUBBS JULIE L
权利人:MOLECULAR ASSEMBLIES INC
摘要:Provided herein are methods for template-independent synthesis of oligonucleotides using a DNA polymerase. Also provided are methods for template-directed synthesis of oligonucleotides and for sequencing of nucleic acids using DNA polymerase theta and 3′-aminoalkoxy nucleotides.

专利号:CN-113528471-B
优先权日:2021-07-20
标 题 :A kind of trifunctional enzyme for de novo synthesis of flavanones and its synthesis method and application

专利号:US-7244602-B2
优先权日:1998-03-13
标题:Polymerase chimeras
发明人：FREY BRUNO; VILLBRANDT BRITTA; SCHOMBURG DIETMAR; SOBEK HARALD; ANKENBAUER WALTRAUD
权利人:ROCHE DIAGNOSTICS GMBH
摘要:The invention concerns polymerase chimeras which are composed of amino acid fragments representing domains and which combine properties of naturally occurring polymerases that are advantageous with regard to a particular application. It has surprisingly turned out that the domains from the various enzymes are active in the chimeras and exhibit cooperative behavior. In addition the present invention concerns a process for the production of the chimeras according to the invention and the use of these chimeras for the synthesis of nucleic acids e.g. during a polymerase chain reaction. Moreover the present invention concerns a kit which contains the polymerase chimeras according to the invention.

专利号:CN-114717170-B
优先权日:2021-01-05
标题:Host cell for heterologous synthesis of flavonoid compounds and application thereof

专利号:CN-111684066-B
优先权日:2017-01-05
标题 :Genes related to the synthesis of cyclic peptide compounds, methods for producing cyclic peptide compounds using the genes, and transformants having the genes