CAS: 102074-19-1; (5-Methylpyridin-3-yl)Methanol

该化合物是一种多用途的环环环醇,其核心为,其特点是三级的氢氧化甲基组和五级的甲基替代组.该化合物由于其反应性氢氧基组和稳定的丙烯基脊柱,是有机合成,特别是制药和农用化学应用的宝贵中间体.其结构特性使得高效衍生,有利于生物活性分子的开发.该化合物在极地有机溶剂中表现出良好的溶解性,增强了其在反应系统中的效用.高纯度可用于满足严格的研究和工业要求,确保合成工作流程的一贯性能.

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29681-45-6 3222-49-9 100910-66-5

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CAS号29681-45-6 5-甲基烟酸甲酯 | CAS号92444-99-0 2-氯-5-甲基吡啶-3-甲醛 | CAS号3222-49-9 5-甲基烟酸 | CAS号591-22-0 3,5-二甲基吡啶 | CAS号100910-66-5 5-甲基吡啶-3-甲醛 | CAS号1235342-53-6 3-(溴甲基)-5-甲基吡啶氢溴酸盐

合成工艺路线路线简述

    📜3,5-二甲基吡啶置于盐酸,Potassium Permanganate,Lithium Aluminium Tetrahydride体系中,用 乙醚,水 用作溶剂,化学反应 5.5H,反应生成5-甲基-3-吡啶甲醇
    参考文献:A General Synthesis Of Substituted Fluorenones And Azafluorenones
    标题:A General Synthesis Of Substituted Fluorenones And Azafluorenones
    摘要:
    Doi:10.1021/jo00250A019

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    专利信息


    专利号:US-8598166-B2
    优先权日:2008-03-21
    标 题:Polysubstituted derivatives of 6-heteroarylimidazo[1,2-a]pyridines, and preparation and therapeutic use thereof
    发明人：DE PERETTI DANIELLE; EVANNO YANNICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE
    权利人:DE PERETTI DANIELLE; EVANNO YANNICK; MACHNIK DAVID; RAKOTOARISOA NATHALIE; SANOFI SA
    摘要:Compounds of formula (I): n nwherein R 1 , R 2 , R 3 , R 4 , Het and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.

    专利号:US-8952042-B2
    优先权日:2009-08-19
    标 题 :FXR (NR1H4) binding and activity modulating compounds
    发明人：KREMOSER CLAUS; ABEL ULRICH; STEENECK CHRISTOPH; KINZEL OLAF
    权利人:KREMOSER CLAUS; ABEL ULRICH; STEENECK CHRISTOPH; KINZEL OLAF; PHENEX PHARMACEUTICALS AG
    摘要:The present invention relates to compounds of formula (1): n nwhere R, A, Q and Z are defined herein, or an enantiomer, diastereomer, tautomer, solvate, prodrug or pharmaceutical acceptable salt thereof. These compounds bind to the NR1H4 receptor (FXR) and act as agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.

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    合成参考文献

    参考DOI号:10.1021/jm049640t
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