CAS: 1005334-57-5; 3-(((3-(4-(Methylsulfonamido)Phenyl)-4-Oxo-4H-Chromen-7-yl)Oxy)Methyl)Benzoic Acid
- 英文名称3-(((3-(4-(Methylsulfonamido)Phenyl)-4-Oxo-4H-Chromen-7-yl)Oxy)Methyl)Benzoic Acid
- 中文名称3-[[[3-[4-[(甲基磺酰基)氨基]苯基]-4-氧代-4H-苯并吡喃-7-基]氧基]甲基]苯甲酸
- IUPAC名称3-(((3-(4-(methylsulfonamido)phenyl)-4-oxo-4H-chromen-7-yl)oxy)methyl)benzoic acid
- CAS编号1005334-57-5
- MFCD编号:MFCD18072197
- FDA UNII编号:F9H432757X
- 分子式:C24H19NO7S分子量:465.48
- 产品CID: 12114
- 同类组份化合物CAS1005334-57-5
- 产品分类生物化工 → 生化试剂 → 激动剂抑制剂
物理性质
MSDS等安全信息
合成工艺路线路线简述
📜3-[3-(4-Nitrophenyl)-4-Oxo-4H-Chromen-7-Yloxymethyl]Benzoic Acid Allyl Ester置于四(三苯基膦)钯 吗啉,吡啶,Sodium Dithionite,水体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应 23.0H,反应生成3-[[[3-[4-[(甲基磺酰基)氨基]苯基]-4-氧代-4H-苯并吡喃-7-基]氧基]甲基]苯甲酸
参考文献:Aldh-2 Inhibitors In The Treatment Of Drug Addiction
标题:Aldh-2 Inhibitors In The Treatment Of Drug Addiction
摘要:揭示了具有以下结构的新型异黄酮衍生物,其可用作aldh-2抑制剂,用于治疗哺乳动物对成瘾药物的依赖,例如对多巴胺类药物如可卡因,吗啡,安非他命,尼古丁和酒精的依赖.
海关参考信息
- 2905199090-其他饱和一元醇
2905399099-其他二元醇
2905499000-其他多元醇
2905590090-其他无环醇的卤化、磺化等衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Bocarsly ME, Hoebel BG, Paredes D, von Loga I, Murray SM, Wang M, Arolfo MP, Yao L, Diamond I, Avena NM. GS 455534 selectively suppresses binge eating of palatable food and attenuates dopamine release in the accumbens of sugar-bingeing rats. Behav Pharmacol. 2014 Apr;25(2):147-57. doi: 10.1097/FBP.0000000000000029. Review. doi: 10.1016/j.pbb.2009.09.004. Epub 2009 Sep 10.
4: Arolfo MP, Overstreet DH, Yao L, Fan P, Lawrence AJ, Tao G, Keung WM, Vallee BL, Olive MF, Gass JT, Rubin E, Anni H, Hodge CW, Besheer J, Zablocki J, Leung K, Blackburn BK, Lange LG, Diamond I. Suppression of heavy drinking and alcohol seeking by a selective ALDH-2 inhibitor. Alcohol Clin Exp Res. 2009 Nov;33(11):1935-44. doi: 10.1111/j.1530-0277.2009.01031.x. Epub 2009 Aug 10.
合成参考文献
参考文献:10.1038/s42255-024-01063-2
摘要:Fu Y, Mackowiak B, Lin YH, Maccioni L, Lehner T, Pan H, Guan Y, Godlewski G, Lu H, Chen C, Wei S, Feng D, Paloczi J, Zhou H, Pacher P, Zhang L, Kunos G, Gao B. Coordinated action of a gut-liver pathway drives alcohol detoxification and consumption. Nat Metab. 2024 Jul;6(7):1380–96.
参考文献:10.1007/s12012-024-09923-9
摘要:Liu Y, Liu X, Pan C. Advances in Factors Affecting ALDH2 Activity and its Mechanisms. Cardiovasc Toxicol. 2024 Dec;24(12):1428–38. doi: 10.1007/s12012-024-09923-9.
参考文献:10.1038/s41419-025-07927-z
摘要:Hu X, Hu T, Cao S, Jiang L, Zhou Y, Fang Q, Wang J. The ALDH2/PolG2 axis enhances mitochondrial biogenesis via transcriptional regulation of Nrf2 and promotes chemotherapy resistance in acute myeloid leukaemia. Cell Death Dis. 2025 Aug 13;16(1):616.
参考文献:10.1038/s42255-025-01393-9
摘要:Shen L, Wang S, Gao C, Li Q, Feng S, Sun W, Liu X, Ba Y, Chu Y, Zhou Y, Pan J, Xu H, Zhang X, Zhu W, Qin L, Lu M. Tumour-associated macrophages serve as an acetate reservoir to drive hepatocellular carcinoma metastasis. Nat Metab. 2025 Nov;7(11):2268–83. doi: 10.1038/s42255-025-01393-9.
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