专利号:US-8338621-B2 优先权日:2005-12-21 标题:Process for the preparation of 2-oxo-1-pyrrolidine derivatives 发明人:SURTEES JOHN; BOUVY DIDIER; THOMAS ANTOINE; COMBRET YVES; FRANK MICHAEL; SCHMIDT GUNTHER; DUCHENE GUY 权利人:SURTEES JOHN; BOUVY DIDIER; THOMAS ANTOINE; COMBRET YVES; FRANK MICHAEL; SCHMIDT GUNTHER; DUCHENE GUY; UCB SA 摘要:The present invention relates to alternative processes for the preparation of 2-oxo-1-pyrrolidine derivatives of formula (I) n n n n n n n n n n Particularly, the present invention relates to alternative processes for the synthesis of levetiracetam, brivaracetam and seletracetam.
专利号:US-10370409-B2 优先权日:2011-10-25 标题 :Synthesis of libraries of peptide tertiary amides 发明人:KODADEK THOMAS; GAO YU 权利人:SCRIPPS RESEARCH INST 摘要:The present disclosure is directed to a novel class of peptide-like oligomers called peptide tertiary amides (PTAs) and a combinatorial library of PTAs along with synthetic routes for the preparation of large combinatorial libraries of these compounds. The peptide tertiary amides provide an exceptional source of high affinity and selective protein ligands that are useful as tools for biological research and as drug leads, among others.
专利号:US-2014315831-A1 优先权日:2011-10-25 标 题:Synthesis of Libraries of Peptide Tertiary Amides
专利号:WO-2013063296-A1 优先权日:2011-10-25 标题 :Synthesis of libraries of peptide tertiary amides
专利号:US-9815842-B2 优先权日:2014-05-28 标题 :Pyrazolo pyrimidine derivatives and their use as MALT1 inhibitors 发明人:SOLDERMANN CAROLE PISSOT; QUANCARD JEAN; SCHLAPBACH ACHIM; SIMIC OLIVER; TINTELNOT-BLOMLEY MARINA; ZOLLER THOMAS 权利人:SOLDERMANN CAROLE PISSOT; QUANCARD JEAN; SCHLAPBACH ACHIM; SIMIC OLIVER; TINTELNOT-BLOMLEY MARINA; ZOLLER THOMAS; NOVARTIS AG 摘要:The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.
专利号:EP-2771478-A1 优先权日:2011-10-25 标 题:Synthesis of libraries of peptide tertiary amides