CAS: 957205-23-1; [4-Cyclohexyl-3-(Trifluoromethyl)Phenyl]Methanol

该化合物是一种含氟芳香醇,其特点是环状替代物和苯环上的三氟甲基组,这种结构组合具有独特的消毒和电子特性,使其成为制药和农用化学合成中有价值的中间体.三氟甲基混合物可增强代谢稳定性和亲脂性,而环己醇运动则有助于异性硬性.苯乙烯醇功能允许进一步衍生,包括氧化,酯化或醚化.这种复合物对于生物活性分子的发展特别有用,因为其平衡的缺水性和再活性使类似药物的特性得以精确调节.高纯度等级可用于达到严格的研究和工业标准.

结构式图片

物理性质

MSDS等安全信息

上下游产品

辛波莫德中间体 1-Cyclohexyl-4-Methyl-2-Trifluoromethylbenzene 1449293-48-4
4-环己基-3-三氟甲基苯甲酸 4-Cyclohexyl-3-(Trifluoromethyl)Benzoic Acid 916806-97-8
Methyl 4-Cyclohexyl-3-(Trifluoromethyl)Benzoate 957202-29-8
1-Cyclohexyl-2-(Trifluoromethyl)Benzene 13376-27-7
4-Bromo-1-Cyclohexyl-2-(Trifluoromethyl)Benzene 1449291-53-5
4-环己-1-烯基-3-三氟甲基苯甲酸 4-Cyclohex-1-Enyl-3-Trifluoromethylbenzoic Acid 1034188-31-2
Methyl 2-(Trifluoromethyl)-2',3',4',5'-Tetrahydro-(1,1'-Biphenyl)-4-Carboxylate 957207-18-0
1-Cyclohex-1-Enyl-4-Methyl-2-Trifluoromethylbenzene 1449293-47-3

合成工艺路线路线简述

  • 957202-29-8 = 957205-23-1
    反应条件:1.1 Reagents: Sodium Borohydride Solvents: Ethanol,Tetrahydrofuran; Rt -> 65 °C; 65 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 21.3 Reagents: Sodium Carbonate; Ph 7
    标题:Preparation Of Siponimod Intermediate
    参考文献:China]

    916806-97-8 = 957205-23-1
    反应条件:1.1 Reagents: Borane Solvents: Tetrahydrofuran; 30 Min,0 °C; 3 H,Rt1.2 Reagents: Water; Rt
    标题:Preparation Of Deuterium-Substituted Azetidine Compounds As Sphingosine 1-Phosphate Receptor
    参考文献:World Intellectual Property Organization]

    957202-29-8 = 957205-23-1
    反应条件:1.1 Reagents: Lithium Aluminum Hydride Solvents: Tetrahydrofuran; 0 °C; 0 °C -> Rt; 10 H,Rt
    标题:Preparation Of The Aromatic Ring Derivative As Immunoregulation Agents
    参考文献:World Intellectual Property Organization]

    916806-97-8 = 957205-23-1
    反应条件:1.1 Reagents: Lithium Aluminum Hydride Solvents: Toluene,Tetrahydrofuran; 20 - 50 °C1.2 Reagents: Sulfuric Acid Solvents: Water; 15 - 25 °C
    标题:Process For Preparing N-(4-Cyclohexyl-3-Trifluoromethylbenzyloxy)Acetimidic Acid Ethyl Ester
    参考文献:World Intellectual Property Organization]

    916806-97-8 = 957205-23-1
    反应条件:1.1 Reagents: (Dimethyl Sulfide)Trihydroboron Solvents: Tetrahydrofuran,Water; 17 H,Rt
    标题:Preparation Of Heteroarylamide Derivatives As Immunosuppressants With S1P Agonist Activity
    参考文献:Japan]

    957202-29-8 = 957205-23-1
    反应条件:1.1 Reagents: Sodium Borohydride Solvents: Methanol,Tetrahydrofuran; 65 °C; 65 °C; 5 H,65 °C
    标题:Preparation Of (4-Cyclohexyl-3-(Trifluoromethyl)Phenyl)Methanol
    参考文献:China]

    916806-97-8 = 957205-23-1 + 1449293-49-5
    反应条件:1.1 Reagents: Lithium Aluminum Hydride Solvents: Toluene,Tetrahydrofuran; 3 H,25 °C
    标题:Development Of Scalable Processes For The Preparation Of 4-(Chloromethyl)-1-Cyclohexyl-2-(Trifluoromethyl)Benzene: A Key Intermediate For Siponimod
    作者:Lin,Biyue; Wu,Shuming; Xiao,Qingbo; Kou,Jingping; Hu,Ji'An; Et Al
    参考文献:Organic Process Research & Development 日期:2023 卷标:27(8) 页码:1474-1484]

    957202-29-8 = 957205-23-1
    反应条件:1.1 Reagents: Lithium Aluminum Hydride Solvents: Tetrahydrofuran; 0 °C; 10 H,0 °C -> Rt1.2 Reagents: Water
    标题:Preparation Of Azetidinecarboxylic Acid Compounds As As An S1P1 Agonists And Immunomodulators
    参考文献:World Intellectual Property Organization]

    916806-97-8 = 957205-23-1
    反应条件:1.1 Reagents: Lithium Aluminum Hydride Solvents: Tetrahydrofuran; 0 °C; 1 H,20 °C; 20 °C -> 0 °C1.2 Reagents: Water; Cooled1.3 Reagents: Hydrochloric Acid Solvents: Water
    标题:Process For Preparation Of Siponimod,Its Intermediates And Salts Thereof
    参考文献:India]

    916806-97-8 = 957205-23-1
    反应条件:1.1 Reagents: Lithium Aluminum Hydride Solvents: Tetrahydrofuran; 0 °C; 1 H,20 °C; 20 °C -> 0 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; 0 °C
    标题:Process For Preparation Of Siponimod,Its Salts And Solid State Forms Thereof
    参考文献:World Intellectual Property Organization]

    916806-97-8 = 957205-23-1
    反应条件:1.1 Reagents: (Dimethyl Sulfide)Trihydroboron Solvents: Tetrahydrofuran; 17 H,Rt
    标题:Preparation Of Azacyclo-Alkanecarboxylic Acids,Their Pharmaceutical Compositions,Their Use,And Method For Therapy
    参考文献:Japan]

    = 957205-23-1 [标题:Reaction Conditions
    标题:Preparation Of Benzylamino Carboxylic Acid Derivatives As Immunosuppressants
    参考文献:World Intellectual Property Organization
📜邻溴三氟甲苯置于lithium Chloro-Isopropyl-Magnesium Chloride,Lithium Aluminium Tetrahydride,1,3-二溴-5,5-二甲基海因,硫酸,Palladium 10% On Activated Carbon,氢气,异丙基氯化镁体系中,用 四氢呋喃,甲醇,水,溶剂黄146,甲苯 作为反应溶剂,-5.0~40.0 °C,500.01 Kpa 条件下,反应 3.0H,反应生成 4-环己基-3-(三氟甲基)苯甲醇
参考文献: Process For Preparing N-(4-Cyclohexyl-3-Trifluoromethyl-Benzyloxy)-Acetimidic Acid Ethyl Ester[fr] Procédé De Préparation D'Ester éthylique D'Acide N-(4-Cyclohexyl-3-Trifluorométhyl-Benzyloxy) Acétimidique
标题: Process For Preparing N-(4-Cyclohexyl-3-Trifluoromethyl-Benzyloxy)-Acetimidic Acid Ethyl Ester[fr] Procédé De Préparation D'Ester éthylique D'Acide N-(4-Cyclohexyl-3-Trifluorométhyl-Benzyloxy) Acétimidique
摘要:该发明涉及一种合成n-(4-环己基-3-三氟甲基苄氧基)-乙酰亚胺酸乙酯的新工艺,以及用于这种工艺的式i化合物和其他中间体.

海关参考信息

专利信息


专利号:CN-113896650-A
优先权日:2021-10-27
标 题:Synthesis method of siponimod intermediate

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

⚠️全国化工行业净网倡议书
📋制造商识别码
📖 海关编码查询
📝MSDS生成器

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2019)
📝 需求与反馈
尽可能描述清楚需求与问题信息
×

通知