CAS: 868-59-7; (R)-Ethyl 2-Amino-3-Mercaptopropanoate Hydrochloride

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93964-73-9 10318-18-0 32443-99-5

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CAS号64-17-5 乙醇 | CAS号52-89-1 L-半胱氨酸盐酸盐(无水物) | CAS号52-90-4 L-半胱氨酸 | CAS号130432-17-6 N-(3-nitratopiv... | CAS号70454-09-0 ethyl 2-phenyl-... | CAS号881197-94-0 ethyl 2-[1-[(2-... | CAS号59587-30-3 依替米贝原料药 | CAS号51932-25-3 ethyl 4,5-dihyd... | CAS号3532-25-0 N-phenylmethoxy... | CAS号22735-07-5 L-胱氨酸双(乙酯)二盐酸盐 | CAS号65-85-0 苯甲酸

L-半胱氨酸 以80%的收率获得产物l-半胱氨酸乙酯盐酸盐
参考文献:Convenient Synthesis Of 1,4-Thiazane-3-Carboxylic Acid Derivatives.
标题:Convenient Synthesis Of 1,4-Thiazane-3-Carboxylic Acid Derivatives.
摘要:建立了一种合成 1,4-噻嗪-3-羧酸衍生物的简便方法.l-半胱氨酸甲酯(2A)与一氯丙酮(3A)缩合,然后用硼氢化钠还原,得到(3R,5S)-5-甲基-1,4-噻嗪-3-羧酸甲酯(6A)及其(5R)-甲基异构体(7A),两者的比例为 3.1 :1.使用半胱氨酸异丙酯 (2C) 代替甲酯 (2A),可以更立体选择性地得到相应的 (5S)-甲基异构体 (6E).氯甲基乙基酮(3B)或α-溴苯乙酮(3C)与 2A 反应反应生成相应的 5-取代-1,4-噻嗪-3-羧酸盐.6A 经水解和氧化后得到环木菠萝苷 (1A).
DOI:10.1248/cpb.29.1554

专利信息

专利号:US-8653238-B2
优先权日:2006-02-27
标题:Compositions and methods for transport of molecules with enhanced release properties across biological barriers
发明人：WENDER PAUL A; GOUN ELENA A; JONES LISA R
权利人:WENDER PAUL A; GOUN ELENA A; JONES LISA R; UNIV LELAND STANFORD JUNIOR
摘要:Conjugates of a cargo molecule with a transporter molecule are disclosed, where the cargo molecule and the transporter molecule are linked covalently by a releasable linker. The cargo of the conjugate can be a biologically active agent or a reporter molecule. The transporter modulates the transport of the cargo across a biological barrier (e.g., a cell membrane) compared to the transport of the unconjugated cargo. Releasable linkers suitable for rapid and facile conjugation to various types of cargo and transporters are also disclosed, along with methods for using the linkers in the synthesis of conjugates.

专利号:EP-3030516-B1
优先权日:2013-08-07
标题:The synthesis of core-shell metal-semiconductor nanomaterials
发明人：REVAPRASADU NEERISH; DUNPALL REKHA
权利人:UNIV OF ZULULAND

专利号:US-2019031650-A1
优先权日:2016-01-29
标 题 :Dna alkylation and cross-linking agents as compounds and payloads for targeted therapies
发明人：HERZON SETH; HEALY ALAN; CRAWFORD JASON; VIZCAINO MARIA; NIKOLAYEVSKIY HERMAN
权利人:UNIV YALE
摘要:The present invention is directed to compounds related to precolibactin pharmaceutical compositions based upon these compounds and methods of synthesis which are employed to provide intermediates and final compounds, which are principally alkylating agents and anticancer compounds. The chemical synthetic approach disclosed facilitates the synthesis of numerous precolibactin analogs which can be used in the treatment of cancer.

专利号:US-6849650-B2
优先权日:1998-02-27
标 题:Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PORTER WARREN J; NISSEN JEFFREY S; LATIMER LEE H; AUDIA JAMES E; DROSTE JAMES
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-2012282652-A1
优先权日:2011-02-28
标题 :Preparation of peptide mixtures by protease catalysis designed to provide useful biological and physical properties
发明人：GROSS RICHARD A; VISWANATHAN KODANDARAMAN; QIN XU
权利人:GROSS RICHARD A; VISWANATHAN KODANDARAMAN; QIN XU; POLITECHNIC INST UNIV NEW YORK
摘要:A process for preparing unique peptide mixtures with a broad range of uses using combinations of natural and non-natural amino acid alkyl ester monomers and specific combinations of these monomers as dimers, trimers and higher oligomers selected from the large group of structural motifs that lead to useful physical and/or biological properties and that have been or may be identified from solid state peptide synthesis, isolation of peptides from natural sources, and production of peptides by recombinant DNA methods, or identification of peptides by recombinant methods such as phage display, the method of peptide synthesis comprising a) admixing one or more natural and non-natural amino acid alkyl ester monomer, dimer, trimer and higher oligomers with one or more proteases in a reaction medium; b) heating the mixture to between about 5° C. to about 90° C. for between 5 minutes and 24 hours; and c) recovering the formed oligopeptide.

专利号:WO-8707529-A1
优先权日:1986-06-16
标题:Segmented polymers and method for the synthesis thereof
发明人：BROOK BASIL WILLIAM; DUNK WILLIAM ALBERT EDWARD; BAGULEY MAURICE EDWARD; SAVILLE BRIAN
权利人:COURTAULDS PLC
摘要:A surface active agent contains at least one radical generator group in each of its lipophilic and hydrophilic moieties. A water-in-oil dispersion or oil-in-water dispersions contains a first polymerisable monomer dissolved in the oil phase and a second monomer dissolved in the oil phase and a second monomer dissolved in the aqueous phase. A surface active agent as defined above is dispersed across the interface of the oil phase and the aqueous phase with its lipophilic moiety well solvated by the oil phase and its hydrophilic moiety well solvated by the aqueous phase. A segmented polymer comprising such a surface active agent having at least one lipophilic polymer segment attached to its lipophilic moiety and at least one hydrophilic polymer segment attached to its hydrophilic moiety can be formed from the dispersion.