专利号:US-11028057-B2 优先权日:2018-02-28 标题:Process for the synthesis of 6-chloromethyluracil 发明人:MORANA FABIO; GOBBATO STEFANO; ROLETTO JACOPO; PAISSONI PAOLO 权利人:PROCOS SPA 摘要:The invention relates to a process for the synthesis of 6-chloromethyluracil (6-(chloromethyl)pyrimidin-2,4(1H,3H)-dione) from ethyl 4-chloroacetoacetate and S-methylisothiourea hemisulfate via isolation of the novel intermediate 6-(chloromethyl)-6-hydroxy-2-(methylthio)-5,6-dihydropyrimidin-4(1H)-one, and its subsequent treatment with aqueous sulfuric acid. Formula (I).
专利号:US-2023068064-A1 优先权日:2019-12-02 标题 :Process for synthesis of a 2-thioalkyl pyrimidine 发明人:HONG JUNBAE 权利人:FMC CORP 摘要:A method for preparing a compound of Formula 1 and compounds therefrom, comprising treating a compound of Formula 2 with a compound of Formula 3 and reacting the resulting intermediate of Formula 4 with a compound of Formula 5 (or a salt thereof). The compound of Formula 1, prepared by the above method, can be used to prepare a compound of Formula 8 wherein R2, R3, R4, m and r are as defined in the specification.
专利号:US-12291525-B2 优先权日:2019-12-02 标题:Process for synthesis of a 2-(5-isoxazolyl)-phenol 发明人:HONG JUNBAE; BRUENING JOERG 权利人:FMC CORP 摘要:A method for preparing a compound of Formula (1) and compounds therefrom, comprising treating a compound of Formula (2) to provide a compound of Formula (5) and treating the compound of Formula (5) with a hydroxylamine salt wherein R1, R2 and m are as defined in the specification. The compound of Formula (1), prepared by the above method, can be used to prepare a compound of Formula (8) wherein R1, R2, R3 and m are as defined in the specification.
专利号:WO-2011156355-A1 优先权日:2010-06-09 标题 :Production method of phenyl guanidine salts and their intermediates 发明人:JOHNSON MICHAEL ROSS; KANG MYUNG-CHOL; BRAY BRIAN L; SCHNEIDER STEPHEN 权利人:KAINOS MEDICINE INC; JOHNSON MICHAEL ROSS; KANG MYUNG-CHOL; BRAY BRIAN L; SCHNEIDER STEPHEN 摘要:This invention relates to methods for producing phenyl guanidine salts having pharmacological activity, as well as to the identification and synthesis of compounds useful as intermediates for producing phenyl guanidine salts having pharmacological activity.
专利号:US-2023061554-A1 优先权日:2019-12-02 标 题:Process for synthesis of a 2-(5-isoxazolyl)-phenol
专利号:AU-2020398861-A1 优先权日:2019-12-02 标题 :Process for synthesis of a 2-(5-isoxazolyl)-phenol
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