合成目标产物 Riboflavin 主要起始原料 Barbituric Acid And 1-Deoxy-1-(6-Phenylazo-3,4-Xylidino)-D-Ribitol
67-52-7 = 83-88-5 反应条件:1.1 Solvents: Acetic Acid 标题:Reaction Between O-Aminoazo Compounds And Barbituric Acid. A New Synthesis Of Riboflavin 作者:Tishler,Max; Et Al 参考文献:Journal Of The American Chemical Society 日期:1947 卷标:69 页码:1487-92]
13345-95-4 = 83-88-5 反应条件:1.1 Reagents: Artemisinin Solvents: Acetonitrile,Water; < 10 Min,Ph 7.4,Rt 标题:Facile Oxidation Of Leucomethylene Blue And Dihydroflavins By Artemisinins: Relationship With Flavoenzyme Function And Antimalarial Mechanism Of Action 作者:Haynes,Richard K.; Et Al 参考文献:Chemmedchem 日期:2010 卷标:5(8) 页码:1282-1299]
83-88-5 = 83-88-5 反应条件:1.1 Reagents: 1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dimethyl Sulfoxide,Dimethylformamide; 24 H,Rt1.2 Solvents: Water; Ph 7.2,Rt 标题:Design Of Riboflavin-Presenting Pamam Dendrimers As A New Nanoplatform For Cancer-Targeted Delivery 作者:Thomas,Thommey P.; Et Al 参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2010 卷标:20(17) 页码:5191-5194]
58-86-6 + 50-99-7 = 83-88-5 反应条件:1.1 24 H,Rt 标题:Dynamic Control Strategy To Produce Riboflavin With Lignocellulose Hydrolyzate In The Thermophile Geobacillus Thermoglucosidasius 作者:Wang,Junyang; Et Al 参考文献:Acs Synthetic Biology 日期:2022 卷标:11(6) 页码:2163-2174]
50-99-7 = 83-88-5 反应条件:1.1 Catalysts: Glucose 6-Phosphate Dehydrogenase,Ribose Phosphate Isomerase,Gtp Cyclohydrolase Ii,3,4-Dihydroxy-2-Butanone 4-Phosphate Synthase Solvents: Water; 18 H,Ph 6.8,41 °C 标题:Increased Production Of Riboflavin By Coordinated Expression Of Multiple Genes In Operons In Bacillus Subtilis 作者:You,Jiajia; Et Al 参考文献:Acs Synthetic Biology 日期:2022 卷标:11(5) 页码:1801-1810]
58-86-6 = 83-88-5 反应条件:1.1 Solvents: Water; 400 H,28 °C 标题:Producing Biochemicals In Yarrowia Lipolytica From Xylose Through A Strain Mating Approach 作者:Li,Haibo; Et Al 参考文献:Biotechnology Journal 日期:2020 卷标:15(2)]
17014-74-3 + 130971-02-7 = 83-88-5 反应条件:1.1 Catalysts: Lumazine Synthase Solvents: Dimethyl Sulfoxide,Water; Ph 7.0,Rt2.1 Catalysts: Riboflavin Synthase Solvents: Dimethyl Sulfoxide; Ph 7.0,Rt 标题:A New Series Of N-[2,4-Dioxo-6-D-Ribitylamino-1,2,3,4-Tetrahydropyrimidin-5-Yl]Oxalamic Acid Derivatives As Inhibitors Of Lumazine Synthase And Riboflavin Synthase: Design,Synthesis,Biochemical Evaluation,Crystallography,And Mechanistic Implications 作者:Zhang,Yanlei; Et Al 参考文献:Journal Of Organic Chemistry 日期:2008 卷标:73(7) 页码:2715-2724]
61-73-4 = 83-88-5 + 61-73-4 反应条件:1.1 Reagents: Sodium Dithionite Solvents: Water; Ph 7.42.1 Reagents: Artemisinin Solvents: Acetonitrile,Water; Ph 7.4,37 °C 标题:Facile Oxidation Of Leucomethylene Blue And Dihydroflavins By Artemisinins: Relationship With Flavoenzyme Function And Antimalarial Mechanism Of Action 作者:Haynes,Richard K.; Et Al 参考文献:Chemmedchem 日期:2010 卷标:5(8) 页码:1282-1299]
21037-26-3 + 67-52-7 = 83-88-5 反应条件:1.1 Reagents: Acetic Acid Solvents: Acetic Acid,1-Butanol 标题:Some Developments In The Synthesis Of Vitamin B2 作者:Shaps,I. A.; Et Al 参考文献:Khimiko-Farmatsevticheskii Zhurnal 日期:1986 卷标:20(1) 页码:102-5]
21037-26-3 + 67-52-7 = 83-88-5 反应条件:1.1 Reagents: Acetic Acid Solvents: 1-Butanol; 5 H,Reflux; 1 H,0 °C 标题:Site-Selective Synthesis Of 15N- And 13C-Enriched Flavin Mononucleotide Coenzyme Isotopologues 作者:Neti,Syam Sundar; Et Al 参考文献:Journal Of Organic Chemistry 日期:2016 卷标:81(12) 页码:5087-5092]
2535-20-8 = 83-88-5 反应条件:1.1 Catalysts: Riboflavin Synthase Solvents: Dimethyl Sulfoxide; Ph 7.0,Rt 标题:A New Series Of N-[2,4-Dioxo-6-D-Ribitylamino-1,2,3,4-Tetrahydropyrimidin-5-Yl]Oxalamic Acid Derivatives As Inhibitors Of Lumazine Synthase And Riboflavin Synthase: Design,Synthesis,Biochemical Evaluation,Crystallography,And Mechanistic Implications 作者:Zhang,Yanlei; Et Al 参考文献:Journal Of Organic Chemistry 日期:2008 卷标:73(7) 页码:2715-2724]
50-99-7 = 83-88-5 反应条件:1.1 24 H,Rt 标题:Dynamic Control Strategy To Produce Riboflavin With Lignocellulose Hydrolyzate In The Thermophile Geobacillus Thermoglucosidasius 作者:Wang,Junyang; Et Al 参考文献:Acs Synthetic Biology 日期:2022 卷标:11(6) 页码:2163-2174]
50-99-7 = 83-88-5 反应条件:1.1 Reagents: Nadph,Nadp Catalysts: Guanosine 5′-Monophosphate Reductase Solvents: Water; 25 °C 标题:Rational Engineering Of Escherichia Coli For High-Level Production Of Riboflavin 作者:Liu,Shuang; Et Al 参考文献:Journal Of Agricultural And Food Chemistry 日期:2021 卷标:69(41) 页码:12241-12249]
57-48-7 = 83-88-5 反应条件:1.1 Reagents: Dipotassium Phosphate,Calcium Chloride; 72 H,28 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 6 标题:A Novel Strain Of Acetic Acid Bacteria Gluconobacter Oxydans Fbfs97 Involved In Riboflavin Production 作者:Noman,Abeer Essam; Et Al 参考文献:Scientific Reports 日期:2020 卷标:10(1)]
58-86-6 = 83-88-5 反应条件:1.1 24 H,Rt 标题:Dynamic Control Strategy To Produce Riboflavin With Lignocellulose Hydrolyzate In The Thermophile Geobacillus Thermoglucosidasius 作者:Wang,Junyang; Et Al 参考文献:Acs Synthetic Biology 日期:2022 卷标:11(6) 页码:2163-2174]
57-13-6 + 105-53-3 = 83-88-5 反应条件:1.1 Reagents: Sodium Solvents: Methanol; Rt1.2 7 H,Reflux1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 42.1 Reagents: Acetic Acid Solvents: 1-Butanol; 5 H,Reflux; 1 H,0 °C 标题:Site-Selective Synthesis Of 15N- And 13C-Enriched Flavin Mononucleotide Coenzyme Isotopologues 作者:Neti,Syam Sundar; Et Al 参考文献:Journal Of Organic Chemistry 日期:2016 卷标:81(12) 页码:5087-5092]
3051-94-3 = 83-88-5 反应条件:1.1 Reagents: Sodium Nitrite,Hydrochloric Acid Solvents: Water1.2 Reagents: Sodium Acetate Solvents: Water2.1 Reagents: Acetic Acid Solvents: Acetic Acid,1-Butanol 标题:Some Developments In The Synthesis Of Vitamin B2 作者:Shaps,I. A.; Et Al 参考文献:Khimiko-Farmatsevticheskii Zhurnal 日期:1986 卷标:20(1) 页码:102-5]
13345-95-4 + 613-11-6 = 83-88-5 + 61-73-4 反应条件:1.1 Reagents: Artemisinin Solvents: Acetonitrile,Water; Ph 7.4,37 °C 标题:Facile Oxidation Of Leucomethylene Blue And Dihydroflavins By Artemisinins: Relationship With Flavoenzyme Function And Antimalarial Mechanism Of Action 作者:Haynes,Richard K.; Et Al 参考文献:Chemmedchem 日期:2010 卷标:5(8) 页码:1282-1299
专利号:US-RE37449-E 优先权日:1987-02-06 标题:Process of synthesis of 3′,4′-anhydrovinblastine, vinblastine and vincristine 发明人:KUTNEY JAMES P; CHOI LEWIS S L; NAKANO JUN; TSUKAMOTO HIROKI; BOULET CAMILLE A; MCHUGH MICHAEL 权利人:UNIV BRITISH COLUMBIA 摘要:The present invention relates to the synthesis of dimer alkaloid compounds, particularly those of the Catharantus (Vinca) family, from an indole unit, such as cantharanthine, and a dihydroindole unit, such as vindoline. A multi-step process is disclosed including the steps of (1) of 1,4-reduction of a first dimeric iminium intermediate to an enamine compound by reaction with a 1,4-dihydropyridine compound; (2) oxidative transformation of the resulting enamine to a second iminium intermediate under controlled aeration; (3) reduction of the second iminium intermediate to form the target dimer alkaloid compounds. The entire process can be conducted in a one-pot operation to obtain the target compounds without isolation of the intermediates.
专利号:EP-2021360-B1 优先权日:2006-04-26 标 题:CYCLODIPEPTIDE SYNTHETASE AND ITS USE FOR SYNTHESIS OF CYCLO(TYR-Xaa) CYCLODIPEPTIDES 发明人:BELIN PASCAL; GONDRY MURIEL; THAI ROBERT; PERNODET JEAN-LUC; GENET ROGER 权利人:COMMISSARIAT ENERGIE ATOMIQUE; KYOWA HAKKO BIO CO LTD; UNIV PARIS SUD 11; CENTRE NAT RECH SCIENT 摘要:Isolated, natural or synthetic polynucleotide and polypeptide encoded by said polynucleotide, that is involved in the synthesis of cyclodipeptides, recombinant vector comprising said polynucleotide or any substantially homologous polynucleotide, host cell modified with said polynucleotide or said recombinant vector and also methods for in vitro and in vivo synthesizing cyclodipeptides, in particular cyclo(Tyr-Xaa) cyclodipeptides, wherein Xaa is any amino acid and their derivatives and applications thereof.
专利号:EP-2021357-B1 优先权日:2006-04-26 标 题:Cyclodipeptide synthetases and their use for synthesis of cyclo(leu-leu) cyclodipeptide 发明人:GONDRY MURIEL; THAI ROBERT; BELIN PASCAL; GENET ROGER; PERNODET JEAN-LUC 权利人:COMMISSARIAT ENERGIE ATOMIQUE; KYOWA HAKKO BIO CO LTD; UNIV PARIS SUD; CENTRE NAT RECH SCIENT 摘要:Isolated, natural or synthetic polynucleotides and the polypeptides encoded by said polynucleotides, that are involved in the synthesis of cyclodipeptides, the recombinant vectors comprising said polynucleotides or any substantially homologous polynucleotides, the host cell modified with said polynucleotides or said recombinant vectors and also methods for in vitro and in vivo synthesizing cyclo(Leu-Leu) cyclodipeptide and its derivatives and applications thereof.
专利号:US-4567260-A 优先权日:1982-07-01 标题:Synthesis of 5-deazariboflavine 发明人:YONEDA FUMIO 权利人:TOYO JOZO KK 摘要:A new synthesis of 5-deazariboflavine is afforded by condensing N-D-ribityl-3,4-xylidine with a novel chemical intermediate, 6-chloro-5-formyluracil.
专利号:US-2002055171-A1 优先权日:1998-05-27 标题 :Preparation of biologically active 3-methyleneoxindole and definition of its application in stimulation of plant growth and tissue repair 发明人:TULI VIRENDA KUMAR 摘要:Identification of the true nature and metabolic action of 3 -methyleneoxindole (MO), a naturally occurring catabolite of the plant auxin, indole- 3 -acetic acid (IAA). Description of the two novel methods of synthesis of MO which produce the pure, biologically active auxin compound of MO. Discovery and description of the causes for the erroneous classification of MO as an inert compound with no auxin activity. These findings and methods of synthesis correct the ubiquitous theoretical errors which have driven scientific investigation and plant science research of plant auxins for nearly forty years. n Researchers have failed to observe the auxin activity of MO because of the use of standard but incorrect synthetic techniques which have consistently produced impure forms of 3 -bromooxindole- 3 -acetic acid ( 3 -Brox), the synthetic precursor of MO. In addition, the use of dimethylsulfooxide as a solvent for MO has been identified as a major source of contamination of MO during synthesis. n This invention describes two novel methods for synthesizing (MO). By using purified MO and avoiding the use of dimethylsulfoxide, it was found that the resulting MO product to be 100 to 1,00 fold more effective than IAA in promoting rooting in plant cuttings; supporting tissue differentiation and growth in stage I, stage II and stage III media used for the micropropagation of explants; promoting the formation of callus tissue over wounded plant parts; and, stimulating the production of interstitial tissue between scion and rootstock to increase the success rate for grafting. Therefore, this invention identifies MO as the dominant auxin in shoot acceleration, root development, wound sealing and scion acceptance. n Finally, the correct pathway from IAA to MO is presented.
专利号:US-7541165-B2 优先权日:2001-10-30 标 题 :Molecular detection systems utilizing reiterative oligonucleotide synthesis 发明人:HANNA MICHELLE M 权利人:RIBOMED BIOTECHNOLOGIES INC 摘要:The present invention provides methods for detecting the presence of a target molecule by generating multiple detectable oligonucleotides through reiterative enzymatic oligonucleotide synthesis events on a defined polynucleotide sequence. The methods generally comprise using a nucleoside, a mononucleotide, an oligonucleotide, or a polynucleotide, or analog thereof, to initiate synthesis of an oligonucleotide product that is substantially complementary to a target site on the defined polynucleotide sequence; optionally using nucleotides or nucleotide analogs as oligonucleotide chain elongators; using a chain terminator to terminate the polymerization reaction; and detecting multiple oligonucleotide products that have been synthesized by the polymerase. In one aspect, the invention provides a method for detecting a target protein, DNA or RNA by generating multiple detectable RNA oligoribonucleotides by abortive transcription.
1: Redmond RW, Kochevar IE. Medical Applications of Rose Bengal- and Riboflavin-Photosensitized Protein Crosslinking. Photochem Photobiol. 2019 Sep;95(5):1097-1115. doi: 10.1111/php.13126. Epub 2019 Jul 10. Review. doi: 10.1002/med.21576. Epub 2019 Mar 29. Review. doi: 10.1002/jimd.12053. Epub 2019 Feb 21. Review. doi: 10.1002/jimd.12058. Epub 2019 Mar 11. Review. Available from http://www.ncbi.nlm.nih.gov/books/NBK525977/ doi: 10.3389/fmicb.2018.01478. eCollection 2018. Review. 7: Saedisomeolia A, Ashoori M. Riboflavin in Human Health: A Review of Current Evidences. Adv Food Nutr Res. 2018;83:57-81. doi: 10.1016/bs.afnr.2017.11.002. Epub 2018 Feb 2. Review. Available from http://www.ncbi.nlm.nih.gov/books/NBK470460/ doi: 10.22038/IJBMS.2017.9257. Review. 10: Marashly ET, Bohlega SA. Riboflavin Has Neuroprotective Potential: Focus on Parkinson's Disease and Migraine. Front Neurol. 2017 Jul 20;8:333. doi: 10.3389/fneur.2017.00333. eCollection 2017. Review.
合成参考文献
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