专利号:US-9365607-B1 优先权日:2012-07-31 标题 :Synthesis of deuterated ribo nucleosides, N-protected phosphoramidites, and oligonucleotides 发明人:SRIVASTAVA SURESH C; YASKO AMY 权利人:ASED LLC 摘要:The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.
专利号:US-2013123466-A1 优先权日:2011-11-14 标题:Simultaneous synthesis of temperature-tunable peptide and gold nanoparticle hybrid spheres 发明人:HUR HOR-GIL; KIM JUNGOK 权利人:HUR HOR-GIL; KIM JUNGOK; KWANGJU INST SCI & TECH 摘要:The present invention relates to a novel synthesis of peptide-gold nanoparticle hybrid spheres comprising a step of forming a hybrid structure by inducing self-assembly of a gold-binding peptide, and forming a gold nanoparticle in the structure at the same time. According to the present invention, size of the structure can be controlled according to temperature, and it can be used for various biomedical and electronic applications using the structure.
专利号:US-5679773-A 优先权日:1995-01-17 标题 :Reagants and methods for immobilized polymer synthesis and display 发明人:HOLMES CHRISTOPHER P 权利人:AFFYMAX TECH NV 摘要:Compounds and methods for solid phase synthesis of organic molecules including peptides, oligonucleotides, benzodiazepines, beta -turn mimetics, and prostaglandins. The present invention provides new reagents in the form of linking groups and resins and substrates having attached linking groups which are useful in solid phase synthesis of high density arrays of organic molecules. The invention also provides methods which increase yields of various organic synthesis strategies.
专利号:US-7718578-B2 优先权日:2003-03-31 标 题 :Method of synthesis and testing of combinatorial libraries using microcapsules 发明人:GRIFFITHS ANDREW DAVID; ABELL CHRIS; HOLLFELDER FLORIAN; MASTROBATTISTA ENRICO 权利人:MEDICAL RES COUNCIL 摘要:The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalizing two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets. The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalized into the microcapsules.
专利号:US-7956169-B1 优先权日:2010-06-16 标题 :Synthesis of novel azo-dyes and their use in oligonucleotide synthesis 发明人:LAIKHTER ANDREI; SRIVASTAVA SURESH C; SRIVASTAVA NAVEEN P 权利人:CHEMGENES CORP 摘要:The invention provides a novel group of azo quencher compositions that are useful as quenchers of fluorescence and to methods for making and using them. The quenchers contain an azo bond and 1,3,3-trimethyl-2-methyleneindoline ring system. The quenchers can be derivatized to facilitate their conjugation to a variety of biologically relevant compounds, including lipids, nucleic acids, peptides, proteins, and the like.
专利号:US-12006540-B2 优先权日:2015-09-28 标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis 发明人:JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J 权利人:UNIV COLUMBIA 摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.
[参考文献]: Amina R Gani, Et Al. Tauroursodeoxycholic Acid Prevents Stress Induced Aggregation Of Proteins In Vitro And Promotes Perk Activation In Hepg2 Cells. Arch Biochem Biophys. 2015 Feb 15:568:8-15. [参考文献]: Boya Feng, Et Al. Methionine Oxidation Accelerates The Aggregation And Enhances The Neurotoxicity Of The D178N Variant Of The Human Prion Protein. Biochim Biophys Acta. 2014 Dec;1842(12 Pt A):2345-56. [参考文献]: Daniel Baier, Et Al. Effect Of High Pressure--Low Temperature Treatments On Structural Characteristics Of Whey Proteins And Micellar Caseins. Food Chem. 2015 Nov 15:187:354-63. [参考文献]: Elena Bogdanovic, Et Al. Idh1 Regulates Phospholipid Metabolism In Developing Astrocytes. Neurosci Lett. 2014 Oct 17:582:87-92. [参考文献]: Matthias Michalek, Et Al. Mechanistic Insights Into The Lipid Interaction Of An Ancient Saposin-Like Protein. Biochemistry. 2015 Mar 10;54(9):1778-86.
合成参考文献
参考文献:10.1016/j.jmb.2010.02.014 摘要:Schuermann JP, Tan A, Tanner JJ, Henzl MT. Structure of Avian Thymic Hormone, a High-Affinity Avian β-Parvalbumin, in the Ca2+-Free and Ca2+-Bound States. Journal of Molecular Biology. 2010 Apr;397(4):991–1002. doi: 10.1016/j.jmb.2010.02.014. 参考文献:10.1016/j.biocel.2010.02.004 摘要:Dave S, Dkhar HK, Singh MP, Gupta G, Chandra V, Mahajan S, Gupta P. Hexafluoroisopropanol-induced helix–sheet transition of stem bromelain: Correlation to function. The International Journal of Biochemistry & Cell Biology. 2010 Jun;42(6):938–47. doi: 10.1016/j.biocel.2010.02.004.