CAS: 7803-65-8; Ammonium Hypophosphite

Ammonium Hydroxide,次磷酸 以 水 作为反应溶剂,化学反应 0.33H,以83%的收率获得产物次磷酸铵
参考文献:磷化氢的金脸:分子内双氢芳基化反应对桥头烷甲基膦的级联反应
标题:磷化氢的金脸:分子内双氢芳基化反应对桥头烷甲基膦的级联反应
摘要:本文报道的是双(芳基甲基)乙炔基膦氧化物的金催化环化的第一个实例.这代表了桥头甲烷膦1的八元杂环的原始方法.金催化剂与三氟甲磺酸结合使用可激活炔烃并诱导双重氢芳基化.机理研究表明,该反应逐步进行,首先形成1 H-异膦酸2-氧化物5.本文所述的相应膦氧化物1的还原和保护也突出了我们针对这种新型的富电子配体的方法的有效性.
DOI:10.1021/acs.Orglett.8B03474

专利信息

专利号:US-2009318592-A1
优先权日:2005-10-11
标 题 :Process for the Synthesis of Amine Ethers
发明人：FREY MARKUS; BROENNIMANN VALERIE
权利人:CIBA GEIGY CORP
摘要:The present invention relates to novel processes for the preparation of a sterically hindered amine ether by reacting a corresponding sterically hindered amine oxide with a ketone or an aldehyde with at least one reactive H in the presence of a peroxydisulphate. Products obtained by this process may be hydrogenated. The compounds made by these processes are particularly effective in the stabilization of polymer compositions against harmful effects of light, oxygen and/or heat and as flame-retardants for polymers.

专利号:US-2008183007-A1
优先权日:2004-10-08
标 题 :Process For the Preparation of Alkyl Phosphinic Acids
发明人：THELIN MATS
权利人:ASTRAZENECA AB
摘要:The present invention relates to a new process for the synthesis of alkyl phosphinic acids, and more particularly to a coupling reaction between an alkylhalide and a hypophosphorous acid derivative by a radical initiated reaction. The invention also relates to compounds obtainable by the method of the invention.

专利号:EP-1943236-A2
优先权日:2005-10-11
标 题 :Process for the synthesis of amine ethers

专利号:WO-2007042422-A2
优先权日:2005-10-11
标题:Process for the synthesis of amine ethers

专利号:US-9133224-B2
优先权日:2010-11-29
标 题:Macrocyclic kinase inhibitors
发明人：CREW ANDREW P; DONG HANQING; FERRARO CATERINA; SHERMAN DAN; SIU KAM W
权利人:CREW ANDREW P; DONG HANQING; FERRARO CATERINA; SHERMAN DAN; SIU KAM W; OSI PHARMACEUTICALS LLC
摘要:Compounds of Formula (I): wherein variables are defined herein, and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers for which FAK inhibition is beneficial.

专利号:JP-2009514803-A
优先权日:2005-10-11
标题:Synthesis method of amine ether