CAS: 7372-30-7; (1S,2R,4As,6As,6Br,8Ar,10S,12Ar,12Br,14Bs)-10-Acetoxy-1,2,6A,6B,9,9,12A-Heptamethyl-1,3,4,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-Octadecahydropicene-4A(2H)-Carboxylic Acid
该化合物是一种自然产生的三叶酸化合物,产自各种植物,特别是Lamiaceae家族的植物,其特征是结构特征,包括一种具有乙酰基质的环球三叶结骨,在聚氨酸结构的三处放置有乙酰基,这种改变增强了其溶解性和生物活性.该化合物展示了一系列生物活动,包括抗炎,抗氧化剂和抗癌特性,使其在药理学研究中引起兴趣.其行动机制往往涉及各种信号路径和基因表达的调节.此外,对3-O-乙酰环丙酸进行了研究,以了解其对甲状腺紊乱的潜在影响及其在癌症细胞中促进流行性疾病的能力.该化合物通常与植物来源隔绝,可以在实验室合成,有助于其研究和潜在治疗用途的可得性.与许多天然产品一样,其功效和安全性是持续调查的对象.
- 英文名称(1S,2R,4As,6As,6Br,8Ar,10S,12Ar,12Br,14Bs)-10-Acetoxy-1,2,6A,6B,9,9,12A-Heptamethyl-1,3,4,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-Octadecahydropicene-4A(2H)-Carboxylic Acid
- 中文名称熊果酸乙酸酯
- IUPAC名称(1S,2R,4aS,6aS,6bR,10S,12aR,12bR,14bS)-10-acetoxy-1,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid
- 其它别名(1S,2R,6As,6As,6Br,8As,12As)-10-Acetyloxy-1,2,6A,6B,9,9,12A-Heptamethyl-2,3,4,5,6,6A,7,8,8A,10,11,12,13,14B-Tetradecahydro-1H-Picene-4A-Carboxylic Acid; (3β)-3-(Acetyloxy)-Urs-12-En-28-Oic Acid; Ursolic Acid Acetate; (3Beta)-3-(Acetyloxy)-Urs-12-En-28-Oic Acid; 3-Acetylursolic Acid; 3β-(Acetyloxy)Urs-12-En-28-Oic Acid
- CAS编号7372-30-7
- MFCD编号:MFCD09752431
- 分子式:C32H50O4分子量:498.75
- 产品CID: 1724754
- 产品分类天然产物 → 萜类
物理性质
上下游产品
acetic acid-(3β-acetoxy-ursen-(12)-oic acid-(28))-anhydride ursolic acid acetic anhydride 3β-acetoxyurs-12-en-28-almethyl 3-acetylursolate uvaol 11-oxo-ursolic acid acetate 3β-acetoxyurs-11-en-28,13-olide合成工艺路线路线简述
📜3β-Acetoxyurs-12-En-28-Al置于铬酸体系中,用 氘代吡啶 作为反应溶剂,化学反应生成 熊果酸乙酸酯
参考文献:Katai,Masaaki; Terai,Tadamasa; Meguri,Haruo,Chemical And Pharmaceutical Bulletin,1983,Vol. 31,# 5,P. 1567-1571
标题:Katai,Masaaki; Terai,Tadamasa; Meguri,Haruo,Chemical And Pharmaceutical Bulletin,1983,Vol. 31,# 5,P. 1567-1571
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Synthesis Of Three Triterpene Series And Their Activity Against Respiratory Syncytial Virus作者:Gloria N. Santos Da Silva,Diana Monti Atik,Jheini L. Antunes Fernandes,Deise De Freitas Do Nascimento,Tiago Fazolo,Ana Paula Duarte De Souza,Simone C. Baggio Gnoatto |发布日期:2018.8
摘要:Without Treatment Were Used As Negative Control. The Triterpene Esterification At The Hydroxyl Group Resulted In 17 Derivatives. The 3,28‐di‐o‐acetylbetulin Derivative (1A) Showed The Best Results For Cell Viability, And Real‐time Pcr Amplification Was Performed For 1A Treatment. Remarkably, One New Anti‐hrsv Prototype Was Obtained Through An Easy Synthesis Of Be, Which Shall Represent An Alternative For
合成参考文献
参考文献:10.1021/np030531b
摘要:Chaturvedula VSP, Gao Z, Jones SH, Feng X, Hecht SM, Kingston DGI. A New Ursane Triterpene from Monochaetum vulcanicum that Inhibits DNA Polymerase β Lyase. J. Nat. Prod. 2004 Apr 17;67(5):899–901. doi: 10.1021/np030531b.
参考文献:10.1007/bf02976624
摘要:Tapondjou LA, Lontsi D, Sondengam BL, Choudhary MI, Park HJ, Choi J, Lee KT. Structure-activity relationship of triterpenoids isolated from Mitragyna stipulosa on cytotoxicity. Arch Pharm Res. 2002 Jun;25(3):270–4. doi: 10.1007/bf02976624.
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