CAS: 7357-67-7; 4-(3-Chloropropyl)Morpholine

相似化合物

134187-43-2 88806-06-8 57616-74-7

上下游产品

CAS号110-91-8 吗啉 | CAS号109-70-6 1-溴-3-氯丙烷 | CAS号4441-30-9 3-(4-吗啉)-1-丙醇 | CAS号861453-11-4 4-甲氧基-3-[3-(4-吗... | CAS号4986-89-4 四丙烯酸异戊四酯 | CAS号246512-44-7 2-氨基-4-甲氧基-5-(3... | CAS号27566-44-5 4-Morpholinepen... | CAS号847949-49-9 4-[(3-氯-4-氟苯基)氨... | CAS号675126-27-9 2-氨基-4-甲氧基-5-(3... | CAS号675126-26-8 4-甲氧基-5-(3-吗啉丙氧... | CAS号123-00-2 N-胺丙基吗啉 | CAS号3169-54-8 Morpholine,4-[3... | CAS号184475-35-2 吉非替尼 | CAS号199327-61-2 7-甲氧基-6-(3-吗啉-4... | CAS号100800-40-6 4-(3-吗啉-4-基-丙氧基)-苯胺

4-(3-羟丙基)吗啉置于氯化亚砜体系中,用 二氯甲烷 作为反应溶剂,化学反应 2.0H,以96%的收率获得产物n-(3-氯丙基)吗啉
参考文献:喹啉新类似物作为端粒g-四链体dna潜在稳定剂的合成和初步评估
标题:喹啉新类似物作为端粒g-四链体dna潜在稳定剂的合成和初步评估
摘要:端粒dna是癌症治疗的潜在选择性靶标,因为与肿瘤相关的端粒酶调节大多数癌细胞中端粒的维持.端粒dna的3'单链末端可以通过适当的小分子折叠成四链体结构.我们描述了一种新型的2,7-双取代的10 H-吲哚并[3,2-B]喹啉类,与双链体dna相比,其对四链dna稳定的选择性增强,并且还制备了一种关键中间体.三取代喹啉的合成.
DOI:10.1016/j.Tet.2007.10.045

专利信息

专利号:US-2024343691-A1
优先权日:2006-12-28
标题:Compositions for modulating a kinase cascade and methods of use thereof
发明人：HANGAUER JR DAVID G; PATRA DEBASIS; CODY JEREMY A; PALMER GRANT J; ISBESTER PAUL K; SALSBURY JONATHON
权利人:ATNX SPV LLC
摘要:The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl) pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure.

专利号:US-10494372-B2
优先权日:2014-11-07
标 题 :Synthesis of copanlisib and its dihydrochloride salt
发明人：PETERS JAN-GEORG; RUBENBAUER PHILIPP; GÖTZ DANIEL; GROSSBACH DANJA; MAIS FRANZ-JOSEF; SCHIRMER HEIKO; STIEHL JUERGEN; LOVIS KAI; LENDER ANDREAS; SEYFRIED MARTIN; ZWEIFEL THEODOR; MARTY MAURUS; WEINGÄRTNER GÃœNTER
权利人:Bayer Pharma AG
摘要:The present invention relates to a novel method of preparing copanlisib, copanlisib dihydrochloride, or hydrates of copanlisib dihydrochloride, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said copanlisib, copanlisib dihydrochloride, or hydrates of copanlisib dihydrochloride. The present invention also relates to copanlisib dihydrochloride hydrates as compounds.

专利号:US-8293739-B2
优先权日:2006-12-28
标题:Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof
发明人：HANGAUER JR DAVID G; COUGHLIN DANIEL; GALE JONATHAN; CODY JEREMY A; PATRA DEBASIS; PALMER GRANT J; ISBESTER PAUL K; SALSBURY JONATHON
权利人:HANGAUER JR DAVID G; COUGHLIN DANIEL; GALE JONATHAN; CODY JEREMY A; PATRA DEBASIS; PALMER GRANT J; ISBESTER PAUL K; SALSBURY JONATHON; KINEX PHARMACEUTICALS LLC
摘要:The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. More specifically, the invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy) phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention.

专利号:US-10035803-B2
优先权日:2014-11-07
标 题:Synthesis of copanlisib and its dihydrochloride salt
发明人：PETERS JAN-GEORG; STIEHL JÃœRGEN; LOVIS KAI
权利人:Bayer Pharma AG
摘要:The present invention relates to a novel method of preparing copanlisib, and copanlisib dihydrochloride, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said copanlisib.

专利号:US-9556120-B2
优先权日:2006-12-28
标题:Compositions for modulating a kinase cascade and methods of use thereof
发明人：HANGAUER JR DAVID G; PATRA DEBASIS; CODY JEREMY A; PALMER GRANT J; ISBESTER PAUL K; SALSBURY JONATHON
权利人:ATHENEX INC
摘要:The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxyl)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxyl)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxyl)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure.

专利号:US-9481660-B2
优先权日:2006-10-02
标题 :Tetra-O-substituted butane-bridge modified NDGA derivatives, their synthesis and pharmaceutical use
发明人：HELLER JONATHAN DANIEL; CHEN QINGQI; LOPEZ ROCIO ALEJANDRA; MORRIS AMANDA JEAN
权利人:HELLER JONATHAN DANIEL; CHEN QINGQI; LOPEZ ROCIO ALEJANDRA; MORRIS AMANDA JEAN; ERIMOS PHARMACEUTICALS LLC
摘要:The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified tetra-O-substituted NDGA compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, metabolic diseases, such as diabetes and hypertension, or a proliferative disease, such as diverse types of cancers.