专利号:WO-2021013997-A1 优先权日:2019-07-25 标 题:Process for the synthesis of n-alkyl-4-pyridinamines
专利号:US-11229591-B2 优先权日:2018-12-21 标 题:Methods for synthesizing zinc-lysine-chloride complex 发明人:JARACZ STANISLAV; PAN LONG 权利人:COLGATE PALMOLIVE CO 摘要:Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc oxide and amino acid hydrochloride with a slight molar excess of amino acid hydrohalide, as well as oral care compositions comprising said complexes made according to said method.
专利号:US-11117906-B2 优先权日:2018-12-21 标题:Methods for synthesizing zinc-lysine-chloride complex 发明人:HAO ZHIGANG; CHENG CHI-YUAN; BRINZARI TATIANA; PAN LONG; SUBRAMANYAM RAVI; EVANS LAUREN; LEITE SERGIO 权利人:COLGATE PALMOLIVE CO 摘要:Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc oxide and amino acid hydrochloride in a solvent comprising a polyol, as well as oral care compositions comprising said complexes made according to said method.
专利号:WO-2024083930-A1 优先权日:2022-10-18 标 题:Topically applied preparation for improving skin condition 发明人:HEUER ANDREA; HÜPEDEN JENNIFER 权利人:BEIERSDORF AG 摘要:The invention relates to a topically applied preparation comprising a combination of substances including antimicrobial peptides (AMP), in particular cyclic peptide compounds based on the synthesis of thiazolidine and oxazolidine components, and skin-soothing substances such as menthoxypropanediol, substances to strengthen the skin barrier such as omega-6 fatty acids, and/or flavonoids such as licochalcone, which act synergetically and selectively against pathogenic bacteria, such as S. aureus and C. acnes , however not against skin-commensal bacteria, such as S. epidermidis . The preparations can be used advantageously for the treatment of acne or atopic dermatitis and to care for skin that has been damaged by acne or atopic dermatitis.
专利号:US-11091502-B2 优先权日:2018-12-21 标 题:Methods for synthesizing zinc-lysine-chloride complex 发明人:HAO ZHIGANG; CHENG CHI-YUAN; BRINZARI TATIANA; PAN LONG; SUBRAMANYAM RAVI 权利人:COLGATE PALMOLIVE CO 摘要:Disclosed herein are improved methods for the synthesis of zinc-amino acid-halide complexes via reaction of zinc halide and amino acid free base in a solvent comprising a polyol, as well as oral care compositions comprising said complexes made according to said method.
专利号:WO-2024083413-A1 优先权日:2022-10-18 标题:Topically applied preparation with antimicrobial peptides 发明人:HEUER ANDREA; HÜPEDEN JENNIFER 权利人:BEIERDSORF AG 摘要:The invention relates to a topically applied preparation comprising a combination of substances including antimicrobial peptides (AMP), in particular cyclic peptide compounds based on the synthesis of thiazolidine and oxazolidine components, and skin-soothing substances such as menthoxypropanediol, substances to strengthen the skin barrier such as omega-6 fatty acids, and/or flavonoids such as licochalcone, which act synergetically and selectively against pathogenic bacteria, such as S. aureus and C. acnes, however not against skin-commensal bacteria, such as S. epidermidis. The preparations can be used advantageously for the treatment of acne or atopic dermatitis and to care for skin that has been damaged by acne or atopic dermatitis.
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合成参考文献
摘要:S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (2021) DOI:10.1021/acsenvironau.1c00008. List downloaded from 参考文献:10.1007/bf03365333 摘要:Kreutzkamp B. [Therapy of atopic eczema in the new light. When the skin barrier is not firm]. MMW Fortschr Med. 2008 Feb 14;150(7):12–4. doi: 10.1007/bf03365333.