CAS: 68621-88-5; Tert-Butyl (3-Aminophenyl)Carbamate

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CAS号18437-64-4 叔丁基(3-硝基苯基)氨基甲酸酯 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号108-45-2 间苯二胺 | CAS号541-69-5 间苯二胺盐酸盐 | CAS号58632-95-4 2-(叔-丁氧基碳酰胺)-2-苯乙腈 | CAS号1257310-85-2 [3-(2-trimethyl... | CAS号99-09-2 间硝基苯胺 | CAS号3320-87-4 3-硝基苯基异氰酸酯 | CAS号436089-66-6 N-(3-氨基-苯基)-4-氟-苯磺酰胺 | CAS号18437-64-4 叔丁基(3-硝基苯基)氨基甲酸酯 | CAS号1374640-70-6 罗西替尼 | CAS号159724-40-0 3-(4-吗啉基)苯胺 | CAS号41148-72-5 2,2,4-三甲基-1,2-二...

间硝基苯胺置于pd 10Percent/c 4-二甲氨基吡啶,氢气,三乙胺体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 N-Boc-间苯二胺
参考文献:N-芳基n'-羟基胍,一氧化氮合酶选择性氧化后的新一类no供体:结构-活性关系.
标题:N-芳基n'-羟基胍,一氧化氮合酶选择性氧化后的新一类no供体:结构-活性关系.
摘要:通过重组诱导型一氧化氮合酶(nos Ii)氧化37个n-羟基胍或相关衍生物(包括18个新的n-芳基n'-羟基胍)的过程中,形成一氧化氮(no).几个带有相对较小的给电子对位取代基的n-芳基n'-羟基胍,例如h,F,Cl,Ch(3),Oh,och(3)和nh(2),导致no的反应生成速率n(ω)-羟基-L-精氨酸(noha)反应生成的no的8%至41%.这些反应的特征与先前报道的nos氧化noha的特征非常相似:(i)严格要求nos含有(6R)-5,6,7,8-四氢-L-生物蝶呤,烟酰胺还原腺嘌呤磷酸二核苷酸和o(2)发生氧化,(II)以1:1的摩尔比形成no和相应的尿素,并且(iii)经典的nos抑制剂(例如n(ω)-硝基-L-精氨酸和s-乙基-异硫氰酸酯)具有很强的抑制作用-硫脲.构效关系研究表明,两个结构因素对于由具有c(三键)noh功能的化合物形成no至关重要.第一个是存在单取代的n-羟基胍
DOI:10.1021/jm011006H

专利信息

专利号:US-9278919-B1
优先权日:2015-03-13
标题:Synthesis of N-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide
发明人：XU YONG
权利人:XU YONG
摘要:A method for preparing BTK inhibitor CC-292 of formula 1, comprising: (1) contacting a compound of formula 2 with a compound of formula 3 to obtain a compound of formula 4; (2) contacting the compound of formula 4 with a compound of formula 5 to obtain a compound of formula 6; (3) contacting the compound of formula 6 with trifluoromethanesulfonic anhydride to obtain a compound of formula 7; and (4) contacting the compound of formula 7 with a compound of formula 8 to obtain the compound of formula 1,

专利号:US-7151112-B1
优先权日:2001-09-04
标题:Pharmaceutical uses and synthesis of nicotinamides
发明人：CUTSHALL NEIL S; JEFFREY SCOTT C
权利人:UCB SA
摘要:This invention is directed to methods of using a compound of the formula n nand pharmaceutically acceptable salts thereof, wherein n, X, R 1 and R 2 are disclosed herein, for treating inflammatory events in an animal subject.

专利号:US-9782406-B2
优先权日:2011-10-25
标 题 :Kinase inhibitor and method for treatment of related diseases
发明人：PAN ZHENGYING; LI XITAO
权利人:UNIV PEKING SHENZHEN GRADUATE SCHOOL; BEIJING RECIPROCAPHARMACEUTICALS CO LTD; BEIJING RECIPROCAPHARMACEUTICALS CO LTD
摘要:Disclosed is a compound of (aminophenylamino) pyrimidyl benzamides and a synthesis method thereof. The compound has Btk-inhibition activity and can be used to treat autoimmune diseases, heteroimmune diseases, cancers or thromboembolic diseases.

专利号:US-9150522-B2
优先权日:2011-10-25
标 题:Kinase inhibitor and method for treatment of related diseases
发明人：PAN ZHENGYING; LI XITAO
权利人:UNIV PEKING SHENZHEN GRAD SCHO; BEIJING RECIPROCAPHARMACEUTICALS CO LTD
摘要:Disclosed is a compound of (aminophenylamino) pyrimidyl benzamides and a synthesis method thereof. The compound has Btk-inhibition activity and can be used to treat autoimmune diseases, heteroimmune diseases, cancers or thromboembolic diseases.

专利号:US-6777432-B1
优先权日:2001-09-04
标 题 :Pharmaceutical uses and synthesis of nicotinamides