CAS: 658-98-0; 3-Chloro-4-Fluorophenylacetonitrile

上下游产品

2-chloro-4-(chloromethyl)-1-fluorobenzene potassium cyanide 1-chloro-2-fluorobenzene sodium cyanide 2-(3-chloro-4-fluorophenyl)acetic acid -crotonsaeure-nitril3-Hydroxy-2-4-fluor-3-chlor-phenyl-crotonsaeure-nitril 2-(3-chloro-4-fluoro-phenyl)-ethylamine 2-(3-chloro-4-fluorophenyl)-4,4,4-trifluoro-3-oxobutanenitrile

📜2-氯氟苯置于硫酸,乙酸酐,溶剂黄146体系中,用 甲醇 作为反应溶剂,化学反应生成 3-氯-4-氟苯乙腈
参考文献:2,4-Diamino-5-[4'-Fluoro-3'-Halogenophenyl]Pyrimidines
标题:2,4-Diamino-5-[4'-Fluoro-3'-Halogenophenyl]Pyrimidines
摘要:
DOI:10.1021/jo01351A050

专利信息

专利号:US-4460604-A
优先权日:1976-06-03
标 题 :4-Amino-4-aryl-cyclohexanones
发明人：LEDNICER DANIEL
权利人:UPJOHN CO
摘要:A class of 4-amine-4-arylcyclohexanones, their ketals, and acid addition salts have been synthesized and found to be useful for relieving pain in animals. Their analgesic activity appears to be of high order, and in addition some exhibit narcotic antagonist activity that is useful in modifying the cardiovascular, respiratory, and behavioral depression caused by other analgesics. Several show mixed analgesic and narcotic antagonist activity. Preferred compounds of the class are 4-(m-hydroxyphenyl)-4-dimethylaminocyclohexanone ethylene ketal, and 4-(m-hydroxyphenyl)-4-(n-butylmethylamino)cyclohexanone ethylene ketal as free bases and as their hydrochloride salts. Processes for synthesis and intermediates are described. Unit dosage forms and therapeutic treatments are disclosed.