CAS: 643-28-7; 2-Isopropylaniline

该化合物是替代的阴离子衍生物,其特点是苯环正方形位置上存在异丙基类,这种结构改变增强了其消毒和电子特性,使其成为有机合成中的宝贵中间体,特别是在农用化学品,药品和特殊化学品的生产中.复合物表明有机溶剂的溶解性比未替代的阴离子更强,有利于在各种反应条件下使用.典型合成条件下的稳定性和与一系列试剂的兼容性进一步突出了其在精细化学制造中的效用.由于芳香胺具有潜在的毒性和反应性,在处理时应当谨慎从事.

结构式图片

欧盟法规

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上下游产品

Isopropylbenzene o-nitr°Cumene 3-methyl-2,3-dihydro-1H-indole 2-isopropenylaniline N-(2-isopropylphenyl)acetamide 2-benzamido-1-isopropylbenzene N-(2-isopropylphenyl)-4-methylbenzenesulfonamide 2-isopropyl-N,N-dimethylbenzeneamine

合成工艺路线路线简述

    异丙苯酚置于氨,氢气体系中,用 1,4-二氧六环 作为反应溶剂,230.0 °C,101.33 Kpa 条件下,以79.41%的收率获得产物2-异丙基苯胺
    参考文献:Highly Selective Amination Of O-And P-Alkyl Phenols Over Pd/al2O3-Bao
    标题:Highly Selective Amination Of O-And P-Alkyl Phenols Over Pd/al2O3-Bao
    摘要:一系列基于钯的催化剂被制备并用于在固定床反应器中进行2,6-二甲基苯酚的胺化反应.其中,Pd/al2O3-Bao催化剂表现出最佳性能,转化率达到99.89%,选择性为91.16%.这些催化剂通过bet,Xrd,Xps,Tem和nh3-Tpd进行了表征.掺杂的bao不仅提高了钯粒子的分散性,还降低了催化剂的酸度,显著提高了催化剂的选择性和稳定性.pd/al2O3-Bao催化剂对于邻位和对位烷基苯酚的催化胺化反应展示了其普遍适用性.
    DOI:10.5012/bkcs.2012.33.2.387

    海关参考信息

    专利信息


    专利号:US-8058477-B2
    优先权日:2006-03-21
    标 题 :Process for the synthesis of arylamines from the reaction of an aromatic compound with ammonia or a metal amide
    发明人:HARTWIG JOHN F; SHEN QILONG
    权利人:HARTWIG JOHN F; SHEN QILONG; UNIV YALE
    摘要:A catalytic process for the synthesis of aromatic primary amines, reagent compositions for effecting the process, and transition metal complexes useful in the process, are provided.

    专利号:US-9982005-B2
    优先权日:2013-04-04
    标 题 :Macrolides and methods of their preparation and use
    发明人:MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
    权利人:HARVARD COLLEGE
    摘要:Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.

    专利号:WO-2024028893-A1
    优先权日:2022-08-01
    标 题:Substituted benzimidazoles for treating viral diseases
    发明人:CHAUDHARI VINOD DINKAR; THAKUR KRISHAN GOPAL; RINGE RAJESH PRAKASH; SINGH DESHKANWAR; KAUR SIMRAN; CHAWLA RAVNEET SINGH; JOSHI AKSHAY
    权利人:COUNCIL OF SCIENT AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN OF S
    摘要:The invention relates to benzimidazole compounds, pharmaceutically acceptable salts thereof and its pharmaceutical compositions for reducing/treating viral infections. The present invention also relates to synthesis of such benzimidazole compounds. The present invention further relates to compositions which comprise such benzimidazole compounds or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination. The compounds of the invention are useful in reducing/treating viral infections particularly coronavirus infections caused by SARS-CoV, MERS-CoV and SARS-CoV-2.

    专利号:EP-0051792-A1
    优先权日:1980-11-08
    标 题 :Derivatives of hydroxamic-acid esters, process for their preparation and their use as herbicides
    发明人:FUEHRER WOLFGANG DR; STETTER JOERG DR; EUE LUDWIG DR; SCHMIDT ROBERT RUDOLF DR
    权利人:BAYER AG
    摘要:Hydroxamic acid derivatives of the formula in which Y represents oxygen or sulfur, R¹ represents hydrogen, alkyl or alkoxy, R² represents hydrogen, alkyl, alkoxy or halogen, R³ represents hydrogen, alkyl, alkoxy or halogen, R < 4> represents hydrogen or alkyl, R <5> represents alkyl, alkenyl, alkynyl or alkoxyalkyl, R <6> represents hydrogen, alkyl, alkenyl, alkynyl or alkoxyalkyl or R <4> and R <5> together represent one Alkylene chain, or R 5 and R 6 together represent an alkylene chain, provided Y is oxygen and Z is halogen, a process for their preparation and their use as herbicides. N-phenylglycine derivatives of the formula in which Y, R¹, R², R³, R <4>, R <5> and R <6> have the meanings given above, several processes for their preparation and their use as intermediates for the synthesis of the substances of formula (I).

    专利号:WO-2009143405-A2
    优先权日:2008-05-22
    标 题:Synthesis of graphene sheets and nanoparticle composites comprising same

    专利号:US-2009234126-A1
    优先权日:2006-03-21
    标 题:Process for the Synthesis of Arylamines from the Reaction of an Aromatic Compound with Ammonia or a Metal Amide
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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Dongzhen Li, Et Al. Zn(Otf)(2)-Catalyzed Addition Of Amines To Carbodiimides: Efficient Synthesis Of Guanidines And Unpredicted Formation Of Zn-N Amido Species. Org Biomol Chem. 2010 Apr 21;8(8):1816-20.

    合成参考文献


    摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 300.
    摘要:Jiang, R.; Yang, P.; You, S.-L., Science of Synthesis: Knowledge Updates, (2023) 1, 162.
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