CAS: 52942-31-1; 2-[3-[4-(3-Chlorophenyl)Piperazin-1-Yl]Propyl]-4,5-Diethyl-1,2,4-Triazol-3-One

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      专利号:US-7576211-B2
      优先权日:2004-09-30
      标题 :Synthesis of thienopyridinone compounds and related intermediates
      发明人:DHANOA DALE S; BECKER OREN; NOIMAN SILVIA; CHEN DONGLI; MARANTZ YAEL; SHACHAM SHARON; HEIFETZ ALEXANDER; INBAL BOAZ; BAR-HAIM SHAY; MOHANTY PRADYUMNA; LOBERA MERCEDES; WU LAURENCE
      权利人:EPIX DELAWARE INC
      摘要:The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.

      专利号:US-2008214827-A1
      优先权日:2004-02-03
      标 题:Synthesis of Cyanoimino-Benzoimidazoles
      发明人:GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
      权利人:EURO CELTIQUE SA
      摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

      专利号:CN-114057659-B
      优先权日:2021-11-02
      标题:An intermediate for the synthesis of sulfentrazone and its synthesis method

      专利号:TW-I655905-B
      优先权日:2012-07-24
      标题 :Contains 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylic acid or a derivative thereof and very long chain fatty acid (VLCFA) Synthesis of herbicidal compositions with fatty acid/fat synthesis inhibiting herbicides

      专利号:US-2006084805-A1
      优先权日:2004-09-30
      标题:Synthesis of thienopyridinone compounds and related intermediates

      专利号:US-7982040-B2
      优先权日:2004-05-17
      标题 :Thienopyridinone compounds and methods of treatment
      发明人:DHANOA DALE S; BECKER OREN; NOIMAN SILVIA; MOHANTY PRADYUMNA; CHEN DONGLI; LOBERA MERCEDES; WU LAURENCE; MARANTZ YAEL; INBAL BOAZ; HEIFETZ ALEXANDER; BAR-HAIM SHAY; SHACHAM SHARON
      权利人:NANOTHERAPEUTICS INC
      摘要:The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.

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      1: Costa A, Martignoni E, Blandini F, Petraglia F, Genazzani AR, Nappi G. Effects of etoperidone on sympathetic and pituitary-adrenal responses to diverse stressors in humans. Clin Neuropharmacol. 1993 Apr;16(2):127-38. doi: 10.1097/00002826-199304000-00005. 108(3):320-6. doi: 10.1007/BF02245118. 46(4):303-12. doi: 10.1007/BF01259336. 32(11):949-62. doi: 10.1080/00498250210163298. 31(11):823-39. doi: 10.1080/00498250110091758. 117(9):103-111. Russian. doi: 10.17116/jnevro201711791103-111. 28(3):174-80. doi: 10.1093/jat/28.3.174. 10(2):151-8. doi: 10.1016/0300-483x(78)90065-3. 32(4):551-6. 16(1):85-100.
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